Retrospective Study of Patients with Acute Presentation for Asthma to an Emergency Department in UK (RAPAE)

NCT06360185 | Not Yet Recruiting

• 1 other identifier: Asthma V2 October 2023
• Study Type: observational
• Target: 400
• Locations: 0 countries
• Sites: N/A

Brief Summary

Study team will obtain a list of all patients who have been seen in A+E over the past 6 years with a discharge diagnosis of asthma. Their history will be reviewed from their A+E notes. Team will obtain weight and height from Electronic prescribing tool and will obtain compliance information and past medical history from participant's GP records. Team will use participant's postcode to word out socio economic status quintile using office of national statistics tool. The following information will be taken from hospital documentation and from GP records.

Conditions

Asthma Acute

Outcome Measures

Primary Outcomes (2)

• Change in body weight

  Information will be taken from hospital documentation and from GP records.

  5 years

• Change in body height

  Information will be taken from hospital documentation and from GP records.

  5 years

Study Arms (1)

Asthmatics presenting to the emergency department in NNUH over 5 years

Asthmatics presenting to the emergency department in NNUH over 5 years

Eligibility Criteria

• Age: 16 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The gender split changes with age: at age 11 years the relative risk of boys compared to girls within asthma population is 1.1 and by age 16 years the relative risk is 0.669. This change in gender association for asthma is poorly understood but highlights the complexities of asthma epidemiology. Adult asthma patients are more likely to be female and the study team would like to investigate if hormonal factors are related to reasons for presentation. This is difficult to elucidate in a retrospective study so the team is hoping that this study will inform them so they can undertake a prospective funded study regarding this service.

You may qualify if:

• All Asthmatics patients who attend Emergency department over 5 years

You may not qualify if:

• None Asthmatics.

Sponsors & Collaborators

• Norfolk and Norwich University Hospitals NHS Foundation Trust: lead

Study Officials

• Sadiyah Hand, FRPC

  Consultant Respiratory Physician

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sadiyah Hand, FRPC

CONTACT

01603 289612; sadiyah.hand@nnuh.nhs.uk

Ashnish Sinha

CONTACT

ashnish.sinha@nnuh.nhs.uk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 15, 2023
• First Posted: April 11, 2024
• Study Start: December 1, 2025
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: February 27, 2025

Record last verified: 2024-03