NCT07431021

Brief Summary

The goal of this study is to see if physical activity in high air pollution is worse than rest in high air pollution.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
330

participants targeted

Target at P75+ for not_applicable

Timeline
14mo left

Started Oct 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress32%
Oct 2025Jul 2027

Study Start

First participant enrolled

October 20, 2025

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

February 3, 2026

Completed
21 days until next milestone

First Posted

Study publicly available on registry

February 24, 2026

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2026

Completed
1.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2027

Expected
Last Updated

April 21, 2026

Status Verified

April 1, 2026

Enrollment Period

6 months

First QC Date

February 3, 2026

Last Update Submit

April 20, 2026

Conditions

Asthma AcuteRespiratory

Keywords

air pollutionphysical activitychildrenexerciseno2Public healthair qualitypollutionpaediatricexposureenvironment

Outcome Measures

Primary Outcomes (1)

  • "Airway resistance" measured by Oscillometry at R5

    measured as oscillometery R5

    Pre-24 hour post exposure

Secondary Outcomes (2)

  • "Small airway resistance" measured by Oscillometry at R5-20

    pre- 24 hour post exposure

  • Immune responses as measured by Il6 in nasal lavage

    pre-24 hour post exposure

Study Arms (2)

Physical activity

EXPERIMENTAL

PE Lesson

Behavioral: PE Lesson

Sedenary

ACTIVE COMPARATOR

Science lesson

Behavioral: science lesson

Interventions

science lessonBEHAVIORAL

children have a 90 minute science lesson outdoors

Sedenary
PE LessonBEHAVIORAL

CHildren have a 90 minute PE lesson outdoors

Physical activity

Eligibility Criteria

Age7 Years - 11 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Attending schools in Central and East London that have been recruited to the study

You may not qualify if:

  • Not able to engage with PE lessons on safety grounds, reported by their parents.
  • Children with learning or physical disabilities sufficient for them to be unable to give informed assent to the study, or to carry out study procedures

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of Medicine and Dentistry

London, E1 2AB, United Kingdom

RECRUITING

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

  • James Scales, PhD

    Queen Mary University London

    PRINCIPAL INVESTIGATOR

  • Abigail Whitehouse, PhD, MD

    QMUL

    PRINCIPAL INVESTIGATOR

Central Study Contacts

James Scales, PhD

CONTACT

+447533897264j.scales@qmul.ac.uk

Abigail Whitehouse, MD,PhD

CONTACT

a.whitehouse@qmul.ac.uk

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
SINGLE GROUP
Model Details: mixed methods. crossover of conditions (physical activity (PE) Vs Sedentary (science)
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 3, 2026

First Posted

February 24, 2026

Study Start

October 20, 2025

Primary Completion

May 1, 2026

Study Completion (Estimated)

July 1, 2027

Last Updated

April 21, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will not share

Locations

GB(1)