Effect of Coffee Consumption on Pain and Intestinal Motility After Caesarean Section:

NCT06359223 | Completed DMC

• 1 other identifier: 2400602
• Study Type: interventional
• Target: 57
• Locations: 1 country
• Sites: 1

Brief Summary

Objective The aim of this study was to investigate whether postoperative coffee intake affects pain levels and bowel motility in women undergoing cesarean delivery. Design: It will be conducted as a randomized controlled experimental study. Method: It is a randomized controlled experimental study: This randomized controlled clinical trial will be conducted between May and December 2024 in accordance with the Consolidated Standards of Reporting Trials. A total of 60 women will be randomly assigned to the intervention group (n=30) or the control group (n=30). Participants in the intervention group will receive 100 mg caffeine in coffee at 6 and 12 hours after surgery in addition to routine postoperative care. The control group will receive only routine postoperative care. Pain will be assessed using Visual Analog Scale (VAS) and bowel activity will be monitored by time to first defecation, gas passage and bowel sounds. Keywords: Caesarean section, Coffee, Pain, Motility

Conditions

Operation; Cesarean Section

Keywords

Caesarean Section; Coffee; pain; Motility

Outcome Measures

Primary Outcomes (2)

• Postoperative Pain

  The visual analog scale (VAS ) is a scale with different names at both ends on a 10 cm long vertical or horizon line. In this study, evaluation was made as "0 = no pain" and "10 = the most severe pain".

  6 hour

• intestinal motility

  24 hour. The patient's bowel sounds will be listened to during the hours

  24 hour

Study Arms (2)

caffeine group

EXPERIMENTAL

Participants in the intervention group will receive 100 mg caffeine in coffee at 6 and 12 hours after surgery in addition to routine postoperative care. The control group will receive only routine postoperative care. Pain will be assessed using Visual Analog Scale (VAS) and bowel activity will be monitored by time to first defecation, gas passage and bowel sounds.

Dietary Supplement: coffee consumption

control group

ACTIVE COMPARATOR

The control group will receive only routine postoperative care. Pain will be assessed using Visual Analog Scale (VAS) and bowel activity will be monitored by time to first defecation, gas passage and bowel sounds.

Other: control group

Interventions

coffee consumption DIETARY_SUPPLEMENT

After cesarean section, patients will be allowed to drink coffee.

caffeine group

control group OTHER

Patients will undergo a routine surgical procedure.

control group

Eligibility Criteria

• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• had a cesarean delivery with spinal anesthesia,
• had a postoperative pain level of 4 or higher,
• could read and write Turkish,
• could communicate effectively with the researchers.

You may not qualify if:

• Those who underwent emergency cesarean section,
• Those with pregnancy complications (e.g., preeclampsia, gestational diabetes, placenta previa),
• Those with a history of chronic gastrointestinal disease (e.g., irritable bowel syndrome, Crohn's disease, ulcerative colitis),
• Those with caffeine sensitivity or allergy,
• Those with chronic pain syndrome or analgesic dependence,
• Those who regularly consume coffee (≥2 cups per day),
• Those who experienced intraoperative complications (e.g., bowel or bladder injury),
• Those who could not comply with the study protocol.

Sponsors & Collaborators

• TC Erciyes University: lead
• KTO Karatay University: collaborator

Study Sites (1)

KTO Karatay Unıversty

Konya, Karatay, 42000, Turkey (Türkiye)

Location

Related Publications (9)

• Zamanabadi MN, Alizadeh R, Gholami F, Seyed Mehdi SA, Aryafar M. Effect of caffeine on postoperative bowel movement and defecation after cesarean section. Ann Med Surg (Lond). 2021 Aug 6;68:102674. doi: 10.1016/j.amsu.2021.102674. eCollection 2021 Aug.

  PMID: 34401138 BACKGROUND

• Abadi F, Shahabinejad M, Abadi F, Kazemi M. Effect of Acupressure on Symptoms of Postoperative Ileus After Cesarean Section. J Acupunct Meridian Stud. 2017 Apr;10(2):114-119. doi: 10.1016/j.jams.2016.11.008. Epub 2016 Dec 27.

  PMID: 28483182 BACKGROUND

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  BACKGROUND

• Goymen, A., Simsek, Y., Ozkaplan, S. E., Ozdurak, H. I., Akpak, Y. K., Semiz, A., & Oral, S. (2017). Effect of gum chewing and coffee consumption on intestinal motility in caesarean sections.

  RESULT

• Tian YT. 2017. China is not"The World's First Cesarean Section Rate".Beijing: Guangming Daily.

  RESULT

• Curran EA, Khashan AS, Dalman C, Kenny LC, Cryan JF, Dinan TG, Kearney PM. Obstetric mode of delivery and attention-deficit/hyperactivity disorder: a sibling-matched study. Int J Epidemiol. 2016 Apr;45(2):532-42. doi: 10.1093/ije/dyw001. Epub 2016 Apr 10.

  PMID: 27063604 RESULT

• Khadem N, Khadivzadeh T. The intelligence quotient of school aged children delivered by cesarean section and vaginal delivery. Iran J Nurs Midwifery Res. 2010 Summer;15(3):135-40.

  PMID: 21589777 RESULT

• Souza JP, Betran AP, Dumont A, de Mucio B, Gibbs Pickens CM, Deneux-Tharaux C, Ortiz-Panozo E, Sullivan E, Ota E, Togoobaatar G, Carroli G, Knight H, Zhang J, Cecatti JG, Vogel JP, Jayaratne K, Leal MC, Gissler M, Morisaki N, Lack N, Oladapo OT, Tuncalp O, Lumbiganon P, Mori R, Quintana S, Costa Passos AD, Marcolin AC, Zongo A, Blondel B, Hernandez B, Hogue CJ, Prunet C, Landman C, Ochir C, Cuesta C, Pileggi-Castro C, Walker D, Alves D, Abalos E, Moises E, Vieira EM, Duarte G, Perdona G, Gurol-Urganci I, Takahiko K, Moscovici L, Campodonico L, Oliveira-Ciabati L, Laopaiboon M, Danansuriya M, Nakamura-Pereira M, Costa ML, Torloni MR, Kramer MR, Borges P, Olkhanud PB, Perez-Cuevas R, Agampodi SB, Mittal S, Serruya S, Bataglia V, Li Z, Temmerman M, Gulmezoglu AM. A global reference for caesarean section rates (C-Model): a multicountry cross-sectional study. BJOG. 2016 Feb;123(3):427-36. doi: 10.1111/1471-0528.13509. Epub 2015 Aug 10.

  PMID: 26259689 RESULT

• Tuzmen HD, Yuksel H, Yazar M, Sayar S, Horasanli JE. The effect of coffee consumption on postoperative pain and bowel motility following cesarean section: a randomized controlled trial. Eur J Obstet Gynecol Reprod Biol. 2025 Nov;314:114723. doi: 10.1016/j.ejogrb.2025.114723. Epub 2025 Sep 13.

  PMID: 40967073 DERIVED

MeSH Terms

Conditions

Pain

Interventions

Control Groups

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods

Study Officials

• HÜMEYRA YÜKSEL, Phd

  KTO Karatay University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 1, 2024
• First Posted: April 11, 2024
• Study Start: May 20, 2024
• Primary Completion: September 15, 2024
• Study Completion: December 30, 2024
• Last Updated: July 14, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)