Effect of Coffee on Postdural Puncture Headache After Cesarean Section

NCT07410741 | Recruiting

• 1 other identifier: HU-GSHS-PHD-SN-2026-1
• Study Type: interventional
• Target: 82
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the effects of postoperative coffee consumption on postdural puncture headache (PDPH) and analgesic use in women undergoing cesarean section with spinal anesthesia.

Conditions

Postdural Puncture Headache

Keywords

Post-Dural Puncture Headache; spinal anesthesia; caffeine; cesarean section; coffee

Outcome Measures

Primary Outcomes (1)

• Incidence of Postdural Puncture Headache

  Incidence of postdural puncture headache will be determined based on the presence or absence of headache at any scheduled assessment during the assessment period, as reported by participants.

  From postoperative hour 6 through postoperative day 5

Secondary Outcomes (3)

• Severity of Postdural Puncture Headache

  From postoperative hour 6 through postoperative day 5

• Postoperative Analgesic Use

  From postoperative hour 6 through postoperative day 5

• Patient Satisfaction Level

  Once prior to hospital discharge

Study Arms (2)

Coffee Consumption Group

EXPERIMENTAL

Participants assigned to this group will consume coffee in addition to standard post-cesarean care under spinal anesthesia.

Dietary Supplement: Coffee Consumption

Standard Care Control Group

NO INTERVENTION

Participants assigned to this arm will receive standard postoperative care following cesarean section under spinal anesthesia, in accordance with routine clinical practice.

Interventions

Coffee Consumption DIETARY_SUPPLEMENT

The first coffee (2 g Nescafe Gold™ in 200 ml of hot water) will be given to the participant within the first hour after starting oral feeding. The second coffee will be scheduled according to the participant's surgery time, individual preferences, and sleep patterns, taking into account the 3-9 hour half-life of caffeine. Participants will be given coffee two more times in the following 24-hour period. Thus, participants will consume coffee four times in 48 hours.

Coffee Consumption Group

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Ability to read, understand, and communicate in Turkish
• Age ≥ 18 years
• Undergoing cesarean section under spinal anesthesia
• Spinal anesthesia administered in the sitting position
• Initiation of oral intake at postoperative hour 6
• No history of physiological discomfort related to coffee consumption based on prior experience (e.g., insomnia, palpitations, headache)
• Ability to understand the study procedures and communicate adequately to provide informed consent

You may not qualify if:

• Patients undergoing emergency cesarean section
• Patients with a history of migraine or other types of chronic headache disorders
• Patients in whom spinal anesthesia was converted to general anesthesia.
• Patients whose oral intake was postponed for any reason in the postoperative period.
• Patients with high-risk pregnancies.
• Use of caffeine-containing analgesic medications during the postoperative period.
• Postoperative cigarette smoking.

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Ankara Bilkent City Hospital

Ankara, Ankara, 06800, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Post-Dural Puncture Headache

Condition Hierarchy (Ancestors)

Headache Disorders, Secondary; Headache Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Zeliha Ozdemir Koken

  Hacettepe University Faculty of Nursing

  STUDY CHAIR

Central Study Contacts

Simay Soyer Icbudak, PhD Candidate

CONTACT

+90 5326029045; simay.soyer@hacettepe.edu.tr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Participants and investigators will not be blinded. Outcome assessment will be performed by an independent statistician who will be blinded to group allocation through coded group assignments (e.g., Group A and Group B).
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Two groups, including an intervention group and a standard care control group.

Study Record Dates

• First Submitted: February 7, 2026
• First Posted: February 13, 2026
• Study Start: February 20, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: March 2, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)