The Effect of White Tea Consumption on Obesity

NCT06357273 | Completed

• 1 other identifier: WhiteTeaAY
• Study Type: observational
• Target: 91
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity is an increasing global public health issue. In general, tea consumption have been shown to offer benefit to obese patients. However, the potential of white tea (WT) to treat and protect from the adverse effects of obesity have not been addressed so far. The aim of this study was to examine the efficacy and impact WT consumption highest in catechins on levels of anthropometric and biochemical values in obese patients.

Conditions

Obesity; Obesity; Endocrine; Obesity Adult Onset

Keywords

White tea; Obesity; Weight loss; Appetite hormones; Inflammation; Lipid profile

Outcome Measures

Primary Outcomes (3)

• Weight loss

  Decrease in body weight

  3 months

• Waist Circumference

  Decrease in waist circumference

  3 months

• Body Mass Index

  Decrease in body mass index

  3 months

Secondary Outcomes (4)

• Tumor Necrosis Factor - alpha

  3 months

• Total cholesterol

  3 months

• Low-Density Lipoprotein cholesterol

  3 months

• High-Density Lipoprotein cholesterol

  3 months

Study Arms (4)

Control (CONT)

Obese patients who did not receive any drugs or herbal supplement were offered to be included in the CONT group.

Orlistat (ORL)

Obese patients who were treated with orlistat were offered to be included in the ORL group.

Metformin (METF)

Obese patients who were treated with metformin were offered to be included in the METF group.

White Tea (WT)

Obese patients who did not receive any drugs, but were taking white tea were offered to be included in the WT group.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Obese individuals who applied to the Endocrinology and Metabolism outpatient clinic of tertiary hospital.

You may qualify if:

• Body Mass Index of 30 and above (kg/m²)

You may not qualify if:

• smoking
• physical disability preventing participating in the exercise programs
• joint problem preventing participating in the exercise programs
• trauma preventing participating in the exercise programs
• malignancy
• history of cerebrovascular disease
• active use of antidepressant drugs

Sponsors & Collaborators

• Recep Tayyip Erdogan University: lead

Study Sites (1)

Recep Tayyip Erdogan University

Rize, 53100, Turkey (Türkiye)

Location

Related Publications (4)

• Castro-Barquero S, Lamuela-Raventos RM, Domenech M, Estruch R. Relationship between Mediterranean Dietary Polyphenol Intake and Obesity. Nutrients. 2018 Oct 17;10(10):1523. doi: 10.3390/nu10101523.

  PMID: 30336572 BACKGROUND

• Taylor EB. The complex role of adipokines in obesity, inflammation, and autoimmunity. Clin Sci (Lond). 2021 Mar 26;135(6):731-752. doi: 10.1042/CS20200895.

  PMID: 33729498 BACKGROUND

• Xia X, Lin Z, Shao K, Wang X, Xu J, Zhai H, Wang H, Xu W, Zhao Y. Combination of white tea and peppermint demonstrated synergistic antibacterial and anti-inflammatory activities. J Sci Food Agric. 2021 Apr;101(6):2500-2510. doi: 10.1002/jsfa.10876. Epub 2020 Oct 30.

  PMID: 33058206 BACKGROUND

• Yang CS, Zhang J, Zhang L, Huang J, Wang Y. Mechanisms of body weight reduction and metabolic syndrome alleviation by tea. Mol Nutr Food Res. 2016 Jan;60(1):160-74. doi: 10.1002/mnfr.201500428. Epub 2015 Dec 9.

  PMID: 26577614 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood samples obtained from routine laboratory investigations were retrieved (10 mL). Serum glucose, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and triglyceride were determined with an autoanalyzer. Human-specific ELISA kits were used to measure leptin, adiponectin, ghrelin, asprosin, tumor necrosis factor alpha, interleukin- 6, interleukin-1β, matrix metallopeptidase-9, pancreatic lipase and 8-hydroxy-2' -deoxyguanosine. Serum malondialdehyde and glutathione levels were measured.

MeSH Terms

Conditions

Obesity; Weight Loss; Inflammation

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Body Weight Changes; Pathologic Processes

Study Officials

• Adnan Yılmaz, Prof.

  Recep Tayyip Erdogan University Medical Faculty

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer

Study Record Dates

• First Submitted: April 4, 2024
• First Posted: April 10, 2024
• Study Start: July 1, 2023
• Primary Completion: November 1, 2023
• Study Completion: December 15, 2023
• Last Updated: April 10, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)