A Light Exposure Tracker Designed to Improve Circadian Rhythms - Aim 1

NCT06356337 | Completed

• 1 other identifier: STUDY-22-01199
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research study is to investigate the relationship between reminder messages sent via text and compliance with a daily morning light intervention designed to advance the circadian clock. Twenty healthy adults will be recruited to participate in a randomized, cross-over study where daily messages are, or are not, provided to remind participants to carry out the intervention.

Conditions

Alzheimer's Disease; Mild Cognitive Impairment

Outcome Measures

Primary Outcomes (1)

• Saliva samples for melatonin levels

  Serial saliva samples will be collected to calculate dim light melatonin onset.

  Baseline and 2-weeks post-intervention for each Arm

Secondary Outcomes (2)

• Light exposure using the Speck

  worn all 12 study weeks

• Sleep time using actigraphy

  worn all 12 study weeks

Study Arms (2)

Light Googles plus reminder text messages

ACTIVE COMPARATOR

Participants use green light goggles for one hour each morning for two consecutive weeks and also receive a daily text message reminding them to wear the light goggles

Device: Light goggles; Behavioral: Daily reminder test message

Light Goggles alone

EXPERIMENTAL

Participants use green light goggles for one hour each morning for two consecutive weeks

Device: Light goggles

Interventions

Light goggles DEVICE

Green light goggles worn for 1 hour each morning for two weeks

Light Goggles alone; Light Googles plus reminder text messages

Daily reminder test message BEHAVIORAL

Participants will receive daily text message reminding them to use light goggles each morning

Light Googles plus reminder text messages

Eligibility Criteria

• Age: 55 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• healthy adults over the age of 55
• score of 25 or greater on MoCA

You may not qualify if:

• Severe sleep apnea
• restless leg syndrome
• obstructing cataracts
• macular degeneration
• diabetic retinopathy
• glaucoma
• use of sleep medications
• brain disease

Sponsors & Collaborators

• Icahn School of Medicine at Mount Sinai: lead

Study Sites (1)

Light and Health Research Center

Menands, New York, 12204, United States

Location

MeSH Terms

Conditions

Alzheimer Disease; Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders; Cognition Disorders

Study Officials

• Mariana Figueiro, PhD

  Ichan School of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 4, 2024
• First Posted: April 10, 2024
• Study Start: February 22, 2024
• Primary Completion: August 15, 2024
• Study Completion: August 15, 2024
• Last Updated: October 14, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)