A Study to Test How BI 456906 is Taken up in the Blood of People With and Without Kidney Problems

NCT06352411 | Completed Phase 1 FDA Drug

• 3 other identifiers: 1404-00092023-508557-13-00U1111-1298-3135
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 2

Brief Summary

This study is open to adults aged between 18 and 80 years of age with a body mass index (BMI) of 20 to 40 kg/m2. People with or without kidney problems can take part in the study. The purpose of this study is to find out how much of a medicine called BI 456906 gets into the blood of people with and without kidney problems. BI 456906 is being developed to treat people with obesity and liver problems. People living with these conditions often also have kidney problems. Therefore, it is important to find out whether kidney problems influence the amount of BI 456906 that gets into the blood. Study participants receive a single dose of BI 456906 as an injection under the skin. Participants are divided into 4 groups based on how well their kidneys work: 1 group without kidney problems, and 3 groups with mild, moderate, and severe kidney problems. Each participant without kidney problems is matched with participants from the other groups based on factors such as age, gender, race, and body mass index (BMI) to ensure accurate comparisons. Participants are in the study for about 2 months. They stay for 5 days and 4 nights at the study site and visit their doctors about 7 times. During these visits, the doctors collect information about participants' health. To assess the study endpoints, the doctors regularly take blood samples from the participants. The participants also answer questions about their well-being. The doctors regularly check participants' health and take note of any unwanted effects.

Conditions

Healthy; Renal Impairment

Outcome Measures

Primary Outcomes (2)

• Area under the concentration-time curve of BI 456906 in plasma over the time interval from 0 to the last quantifiable data point (AUC0-tz)

  up to Day 29

• Maximum measured concentration of BI 456906 in plasma (Cmax)

  up to Day 29

Secondary Outcomes (2)

• Area under the concentration-time curve of BI 456906 in plasma over the time interval from 0 extrapolated to infinity (AUC0-∞)

  up to Day 29

• Occurrence of any treatment-emergent adverse event assessed as drug-related by the investigator

  up to 36 days

Study Arms (4)

Group 1: Participants with normal renal function

EXPERIMENTAL

Combination Product: BI 456906

Group 2: Participants with mild renal impairment

EXPERIMENTAL

Combination Product: BI 456906

Group 3: Participants with moderate renal impairment

EXPERIMENTAL

Combination Product: BI 456906

Group 4: Participants with severe renal impairment

EXPERIMENTAL

Combination Product: BI 456906

Interventions

BI 456906 COMBINATION_PRODUCT

Solution for injection, pre-filled syringe

Also known as: survodutide

Group 1: Participants with normal renal function; Group 2: Participants with mild renal impairment; Group 3: Participants with moderate renal impairment; Group 4: Participants with severe renal impairment

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants will only be included in the trial if they meet the following criteria:
• Male or female participants with age 18 to 80 years, inclusive at the screening visit.
• Body mass index (BMI) of 20.0-40.0 kg/m\^2 (inclusive).
• Signed and dated written informed consent in accordance with the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use -good clinical practice (ICH-GCP) and local legislation prior to admission to the trial.
• Male participants are not required to use contraception. Further criteria apply.
• Renal impairment based on assessment of estimated glomerular filtration rate (eGFR) at screening (severe renal impairment: 10.0-29.9 mL/min, moderate renal impairment: 30.0 - 59.9 mL/min (with at least 4 participants with a GFR between 30.0 and 45.0 mL/min), mild renal impairment: 60.0 - 89.9 mL/min)
• Chronic renal impairment \> 12 months (documented renal impairment indicated by reduced eGFR for more than 12 months until screening)
• Absence of clinically significant abnormalities, as based on a complete medical history including a full physical examination, vital signs (blood pressure (BP), pulse rate (PR)), 12-lead electrocardiogram (ECG), and clinical laboratory tests at screening, with the exception of findings that in the opinion of the investigator are consistent with the participant's renal impairment.

You may not qualify if:

• Any evidence of a concomitant disease assessed as clinically relevant by the investigator
• Diseases of the central nervous system (CNS) (including but not limited to any kind of seizures or stroke), and other relevant neurological or psychiatric disorders (including but not limited to major depressive disorder)
• History of relevant orthostatic hypotension, fainting spells, or blackouts
• Relevant chronic or acute infections Further criteria apply.
• A marked prolongation of ECG interval from the start of the QRS complex (measured from the beginning of the Q wave to the end of the S wave) to the end of the T wave (QT)/QT interval corrected for heart rate, e.g. using the method of Fridericia (QTcF) or Bazett (QTcB)(QTc) interval (such as QTc intervals that are repeatedly greater than 480 milliseconds (ms) in males or repeatedly greater than 500 ms in females) or any other relevant ECG finding at screening
• Acute renal failure or active nephritis
• Nephrotic syndrome
• Impaired hepatic function, including relevant increases in liver enzymes indicating liver disease Further criteria apply.

Sponsors & Collaborators

• Boehringer Ingelheim: lead

Study Sites (2)

CRS Clinical Research Services Kiel GmbH

Kiel, 24105, Germany

Location

CRS Clinical Research Services Mannheim GmbH

Mannheim, 68167, Germany

Location

Related Links

• Related Info

MeSH Terms

Conditions

Renal Insufficiency

Interventions

BI 456906

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 3, 2024
• First Posted: April 8, 2024
• Study Start: May 15, 2024
• Primary Completion: September 16, 2025
• Study Completion: September 16, 2025
• Last Updated: March 13, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

DE (2)