Multiplex PCR for Severe Respiratory Infections During the COVID-19 Pandemic

NCT06349707 | Completed

• 1 other identifier: 2023PI112
• Study Type: observational
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

The hypothesis was that a retrospective investigation of the molecular virological tests in a University hospital could be informative, with the aim to identify non-COVID-19 respiratory viruses during the circulation of SARS-CoV-2, according to systematic population data for public health knowledge.

Conditions

Viral Pneumonia

Keywords

respiratory virus

Outcome Measures

Primary Outcomes (1)

• Occurrence of positive viral PCR assays (not COVID-19) from hospitalizations for respiratory infections.

  Number of patients with positive virological molecular tests (multiplex respiratory panels) from the beginning of 2021 to mid-2022, with the nature of the viruses detected and the chronology of occurrence of positive tests.

  18 months, retrospectively

Secondary Outcomes (1)

• Real-life features of patients in Intensive care (from the whole population - Outcome 1) with positive viral PCR during infectious pneumonia.

  18 months, retrospectively

Study Arms (1)

18 ICU-patients group

18 ICU (Intensive Care Unit)-patients group, from the whole population of patients (1,614) who were hospitalized for respiratory infections from early 2021 to mid-2022 in Nancy University hospital, France.

Other: other: Observational

Interventions

other: Observational OTHER

For 18 ICU patients, retrospective collection of routine bioclinical database (ICCA db)

18 ICU-patients group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

18 Intensive Care Unit (ICU)-patients, from the whole population of patients who were hospitalized for respiratory infections from early 2021 to mid-2022 in Nancy University hospital, France: * from the results of the multiplex FilmArrays PCR tests carried out during the 18 months of the study; * for the ICU files, 18 patients positive for virus by the FilmArray Pneumonia test: ICU patients (or representatives) informed of the data collection that can be used for research (ICCA db)

You may qualify if:

• For adult patients, or minors 'via' parents, able to give consent - 18 intensive care patients

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

Study Sites (1)

Schvoerer

Vandœuvre-lès-Nancy, 54511, France

Location

MeSH Terms

Conditions

Pneumonia, Viral

Condition Hierarchy (Ancestors)

Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 4, 2024
• First Posted: April 5, 2024
• Study Start: April 1, 2024
• Primary Completion: May 1, 2024
• Study Completion: June 1, 2024
• Last Updated: February 18, 2025

Record last verified: 2024-04

Locations

FR (1)