Effect of Nd-YAG Laser on Hypertrophic Scar
Nd-YAG
Efficacy of a Long-Pulsed 1064 nm Nd:YAG Laser (Neodymium-doped Yttrium Aluminium Garnet) for Hypertrophic Scars: A Randomized Controlled Trial
1 other identifier
interventional
40
1 country
1
Brief Summary
A hypertrophic scar is a serious health concern in the industrialized world. Two groups of patients were treated with standard medical care. The experimental group received additional laser therapy. scar assessment was measured immediately before treatment, after 3, and 7 months. T test for comparison before-treatment between the control and study groups. ANOVA with repeated measures test for comparison among other measures.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started May 2022
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 28, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
February 28, 2024
CompletedFirst Submitted
Initial submission to the registry
March 27, 2024
CompletedFirst Posted
Study publicly available on registry
April 4, 2024
CompletedApril 4, 2024
April 1, 2024
1.8 years
March 27, 2024
April 2, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
hypertrophic scar maturation
Changes in the scars' color, vascularity, elevation, and pliability were evaluated and scored using the Vancouver scale (VSS). VSS is from 0 to 14. A lower value indicates a better scar.
before treatment,12 weeks, and then 28 weeks of the treatment.
hypertrophic scar volume
Scar volume was determined using the negative-positive moulage method.
before treatment,12 weeks, and then 28 weeks of the treatment.
Study Arms (2)
Placebo
PLACEBO COMPARATORPatients received standard medical care, nursing, physiotherapy, and a sham laser during the course of treatment
Laser group
ACTIVE COMPARATORPatients received 532 nm laser radiation in addition to standard medical care, nursing, and physiotherapy.
Interventions
Nd-YAG laser at 532nm wavelength every 2 weeks for 14 sessions. patients will also receive standard medical care, nursing, physiotherapy
Eligibility Criteria
You may qualify if:
- Adult patients with hypertrophic scars.
You may not qualify if:
- Patients were excluded if they had taken oral retinoids in the last year.
- Patients had any skin defects.
- Patients had any history of photosensitivity.
- Patients experienced active skin diseases in the treatment regions (such as psoriasis, cancer, or autoimmune disease).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Cairo Universitylead
Study Sites (1)
Faculty of Physical Therapy
Cairo, 12613, Egypt
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assis prof of rehabilitation
Study Record Dates
First Submitted
March 27, 2024
First Posted
April 4, 2024
Study Start
May 1, 2022
Primary Completion
February 28, 2024
Study Completion
February 28, 2024
Last Updated
April 4, 2024
Record last verified: 2024-04