Comparison of the Effects of Lidocaine and Articaine Used for Buccal Infiltration and Supplemental Palatinal Infiltration Anesthesia in Teeth With Irreversible Pulpitis

NCT06342869 | Completed

• 1 other identifier: 690
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Objective: The aim of this study was to compare the effects of articaine or lidocaine in buccal infiltration or palatal infiltration in addition to buccal infiltration in maxillary first or second molars with irreversible pulpitis. Method: Among the patients who applied to Akdeniz University Faculty of Dentistry Endodontic Clinic for the treatment of maxillary molars with irreversible pulpitis, 80 volunteers who met the criteria were included in the study. Eighty patients were divided into 4 groups (n = 20). 1. group buccal infiltration with 4% articaine containing 1:100,000 epinephrine, 2. group buccal infiltration with 2% lidocaine containing 80,000 epinephrine, 3. group buccal and palatinal infiltration with 4% articaine containing 1:100,000 epinephrine, 4.group buccal and palatinal infiltration with 2% lidocaine containing 80.000 epinephrine. Pain during the endodontic procedure was determined and recorded according to the Heft Parker visual analog scale.

Conditions

Fist and Second Molars With ırreversible Pulpitis

Keywords

articaine, lidocaine, irreversible pulpitis, infiltration anesthesia

Outcome Measures

Primary Outcomes (1)

• Assessment of complementary palatinal anesthesia with VAS

  10 minutes after anesthesia is performed

Study Arms (4)

buccal infiltration with 4% articaine containing 1:100,000 epinephrine

EXPERIMENTAL

Procedure: Anesthesia

buccal infiltration with 2% lidocaine containing 80,000 epinephrine

EXPERIMENTAL

Procedure: Anesthesia

buccal and palatinal infiltration with 4% articaine containing 1:100,000 epinephrine

EXPERIMENTAL

Procedure: Anesthesia

buccal and palatinal infiltration with 2% lidocaine containing 80.000 epinephrine

EXPERIMENTAL

Procedure: Anesthesia

Interventions

Anesthesia PROCEDURE

application of different anesthesia techniques

buccal and palatinal infiltration with 2% lidocaine containing 80.000 epinephrine; buccal and palatinal infiltration with 4% articaine containing 1:100,000 epinephrine; buccal infiltration with 2% lidocaine containing 80,000 epinephrine; buccal infiltration with 4% articaine containing 1:100,000 epinephrine

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• The patient must be a healthy individual between the ages of 18 and 65 who is classified as ASA I and II.
• No allergy to local anesthetic substances to be used in the study
• Upper maxillary molars with irreversible pulpitis whose vitality has been proven by pulp tests, with no radiolucency at the root tip
• Not having used any painkillers, antibiotics, antidepressants and sedative drugs in the last 12 hours
• Being capable of understanding the Pain scale

You may not qualify if:

• Allergy to local anesthetics
• Failure to respond to the cold test and electric pulp test performed on the relevant tooth
• Radiolucent lesion in the apical part of the relevant tooth on periapical radiography
• No vital tissue is encountered when the pulp chamber is opened

Sponsors & Collaborators

• Akdeniz University: lead

Study Sites (1)

Akdeniz University

Antalya, 07070, Turkey (Türkiye)

Location

Related Publications (2)

• Kanaa MD, Whitworth JM, Meechan JG. A comparison of the efficacy of 4% articaine with 1:100,000 epinephrine and 2% lidocaine with 1:80,000 epinephrine in achieving pulpal anesthesia in maxillary teeth with irreversible pulpitis. J Endod. 2012 Mar;38(3):279-82. doi: 10.1016/j.joen.2011.11.010. Epub 2011 Dec 22.

  PMID: 22341059 BACKGROUND

• Kolay D, Kirici D. Comparison of the effects of lidocaine and articaine used for buccal infiltration and supplemental palatinal infiltration anesthesia in maxillary molars with irreversible pulpitis: a prospective randomized study. BMC Oral Health. 2025 Feb 8;25(1):207. doi: 10.1186/s12903-025-05552-y.

  PMID: 39923048 DERIVED

MeSH Terms

Interventions

Anesthesia

Intervention Hierarchy (Ancestors)

Anesthesia and Analgesia

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor

Study Record Dates

• First Submitted: February 28, 2024
• First Posted: April 2, 2024
• Study Start: April 1, 2022
• Primary Completion: October 1, 2022
• Study Completion: December 1, 2022
• Last Updated: April 2, 2024

Record last verified: 2024-03

Locations

TU (1)