Metabolic Differences Between Subtypes of Polycystic Ovary Syndrome

NCT06342180 | Completed

• 1 other identifier: Usakupcos1
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

We aimed to investigate serum uric acid levels in patients with different phenotype of policystic ovary syndrome and to compare healthy controls.

Conditions

Uric Acid Concentration, Serum, Quantitative Trait Locus 7; Polycystic Ovary Syndrome

Keywords

polycystic ovary syndrome; uric acid level; PCOS Subtypes

Outcome Measures

Primary Outcomes (1)

• Uric acid levels in PCOS subtypes

  Since there are different metabolic effects in different subtypes of polycystic ovary syndrome; In this study we aimed to investigate whether there is a difference between serum UA levels in different PCOS subtypes and the difference between these subtypes and the healthy group.

  Eight months

Study Arms (5)

Controls

Healthy controls between aged 18 and 35 years

Diagnostic Test: Serum uric acid level

PCOS Subtype 1

Hyperandrogenemia+oligoanovulation+PCO appearance on USG

Diagnostic Test: Serum uric acid level

PCOS Subtype 2

Hyperandrogenemia+oligoanovulation

Diagnostic Test: Serum uric acid level

PCOS Subtype 3

Hyperandrogenemia+ PCO appearance on USG

Diagnostic Test: Serum uric acid level

PCOS Subtype 4

Oligoanovulation+ PCO appearance on USG

Diagnostic Test: Serum uric acid level

Interventions

Serum uric acid level DIAGNOSTIC_TEST

An amount of 2-3 ml of blood sample will be collected from the patients after 8-12 hours of fasting and will be kept frozen at -70 degrees to calculate the serum UA level.

Controls; PCOS Subtype 1; PCOS Subtype 2; PCOS Subtype 3; PCOS Subtype 4

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: female
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Women aged between 18 and 35, age-matched between groups, diagnosed with PCOS and without a known cancer diagnosis, liver and kidney failure, not taking medications that would affect uric acid levels, and without active infection.

You may qualify if:

• Patients who applied for reasons such as hair growth, acne, menstrual irregularity or infertility and were diagnosed with PCOS after examination, biochemical, hormonal and sonographic tests,
• Female patients between the ages of 18-35,
• Patients without known cancer, liver or kidney failure,
• Patients who do not take medications that will affect uric acid levels,
• Female patients without active infection will be included. -

You may not qualify if:

• Female patients under eighteen years of age and \>35 years of age,
• Patients with known cancer, liver and kidney failure,
• Patients taking medications that will affect uric acid levels,
• Patients with active infection will be excluded. -

Sponsors & Collaborators

• Uşak University: lead

Study Sites (1)

Usak Egitim Ve Araştırma Hastanesi

Uşak, 64100, Turkey (Türkiye)

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

An amount of 2-3 ml of blood sample will be collected from the patients after 8-12 hours of fasting and will be kept frozen at -70 degrees to calculate the serum UA levels.

MeSH Terms

Conditions

Polycystic Ovary Syndrome

Condition Hierarchy (Ancestors)

Ovarian Cysts; Cysts; Neoplasms; Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases; Gonadal Disorders; Endocrine System Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. of medicine

Study Record Dates

• First Submitted: March 26, 2024
• First Posted: April 2, 2024
• Study Start: January 1, 2022
• Primary Completion: September 1, 2022
• Study Completion: July 20, 2023
• Last Updated: April 2, 2024

Record last verified: 2024-03

Locations

TU (1)