Relationship Between Central Sensitization and Kinesiophobia in Knee Osteoarthritis

NCT06336278 | Completed

• 1 other identifier: 19/03/2024
• Study Type: observational
• Target: 84
• Locations: 1 country
• Sites: 1

Brief Summary

Objective: The knee joint is one of most common locations in OA. In recent years, it has been accepted that there are different pain phenotypes and patient subgroups in knee OA and that central sensitization (CS) mechanisms are at the forefront in some patients. It is also known that fear of movement, known as kinesiophobia, develops in patients with chronic pain. The aim of this study is to investigate CS and kinesiophobia in patients with knee OA, their relationships with each other, and their effects on pain intensity, functional status, pain catastrophizing and depression. Materials and Methods: Forty-two patients with knee OA and 42 healthy subjects participated in our study. Demographic data, body mass index, habits, comorbidities, medications of participants and disease duration and radiographic grade of knee OA patients were recorded. VAS was used to assess the severity of pain and WOMAC was used to assess pain and functional status in patients with OA. Algometer (pressure pain threshold measurement) and Central Sensitization Inventory were used to evaluate central sensitization in all participants. Pressure pain threshold (PPT) was measured at 3 different points: knee joint, cruris and forearm. The presence of kinesiophobia was assessed with the Tampa Scale af Kinesiophobia (TSK). Pain Catastrophizing Scale (PCS) and Beck Depression Inventory (BDI) were used to assess chronic pain related symptoms.

Conditions

Knee Osteoarthritis; Central Sensitisation; Kinesiophobia

Keywords

pain pressure treshold; algometer; knee osteoarthritis; central sensitization; kinesiophobia

Outcome Measures

Primary Outcomes (3)

• Pain Pressure Treshold

  Algometer was used to detect pressure pain threshold. Higher scores mean better outcomes.

  Day 1

• Central Sensitization

  Central Sensitization Inventory was used to evaluate central sensitization. Minimum value is 0 , maximum value is 100. Higher values means worse outcomes.

  Day 1

• Kinesiophobia

  The presence of kinesiophobia was assessed with Tampa Scale af Kinesiophobia. Minimum value is 17 , maximum value is 68. Higher values means worse outcomes.

  Day 1

Secondary Outcomes (4)

• Pain Catastrophizing

  Day 1

• Depression

  Day 1

• Visuel Analog Scala

  Day 1

• Western Ontario and McMaster Universitesies Osteoarthritis Index

  Day 1

Study Arms (2)

Knee Osteoarthritis

Patients who have knee pain at least 6 months, 45-75 years old, kellgren-lawrence grade 1-3

Diagnostic Test: Pressure Algometer

Control

Subjects who have not knee pain, 45-75 years old

Diagnostic Test: Pressure Algometer

Interventions

Pressure Algometer DIAGNOSTIC_TEST

Pressure algometer is used to detect pain pressure treshold.

Control; Knee Osteoarthritis

Eligibility Criteria

• Age: 45 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Inclusion Criteria for control group: * Being a healthy volunteer between the ages of 45-75 * No pain in the knee and forearm * No mechanical, inflammatory, endocrine, degenerative, degenerative, systemic comorbidities that may affect the knee joint * Body mass index below 35 Exclusion Criteria for control group: * Diagnosed with knee osteoarthritis * Presence of uncontrolled systemic disease * Cooperation limitation or cognitive impairment * Presence of chronic painful disease, rheumatologic disease, peripheral neuropathy * Body mass index of 35 and above

You may qualify if:

• Being a healthy volunteer between the ages of 45-75
• Being diagnosed with knee osteoarthritis according to ACR diagnostic criteria
• Knee pain for at least 6 months
• Kellgren-Lawrence 1, 2 or 3 radiologic grade of knee OA
• Body mass index below 35

You may not qualify if:

• Presence of chronic widespread painful diseases other than osteoarthritis (fibromyalgia syndrome etc.), rheumatologic disease, peripheral neuropathy
• Presence of uncontrolled systemic disease
• Cooperation limitation or cognitive impairment
• Active arthritis in the knee joint to be evaluated
• Presence of prosthesis in the knees
• Pain in the forearm
• Body mass index of 35 and above

Sponsors & Collaborators

• Selda Sarıkaya: lead

Study Sites (1)

Zonguldak Bulent Ecevit Universitiy

Zonguldak, 67100, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Osteoarthritis, Knee; Kinesiophobia

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Phobic Disorders; Anxiety Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator, Clinical Professor

Study Record Dates

• First Submitted: March 19, 2024
• First Posted: March 28, 2024
• Study Start: October 1, 2022
• Primary Completion: October 1, 2023
• Study Completion: December 1, 2023
• Last Updated: April 22, 2024

Record last verified: 2024-04

Locations

TU (1)