NCT06333288

Brief Summary

The goals of this Pilot Trial are to test the preliminary efficacy of Problom-Solving Therapy (PST)-APPLE Watch in a 2-arm pilot Randomized Control Trial (RCT), vs education only-control to reduce alcohol use disorder symptoms and improve alcohol abstinence.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
26

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Apr 2024

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 20, 2024

Completed
7 days until next milestone

First Posted

Study publicly available on registry

March 27, 2024

Completed
19 days until next milestone

Study Start

First participant enrolled

April 15, 2024

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 30, 2024

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 30, 2024

Completed
Last Updated

December 13, 2024

Status Verified

December 1, 2024

Enrollment Period

6 months

First QC Date

March 20, 2024

Last Update Submit

December 9, 2024

Conditions

Outcome Measures

Primary Outcomes (1)

  • Alcohol abstinence

    Participants will be monitored for 3 months to assess alcohol abstinence by blood alcohol content.

    Up to 3 months

Secondary Outcomes (12)

  • Change in AUD severity at 3 months.

    Baseline, 3 months.

  • Change in AUD frequency status.

    Baseline, 3 months.

  • Change in Alcohol-related negative consequences at 3 months.

    Baseline, 3 months.

  • Change in Alcohol use at 3 months.

    Baseline, 3 months.

  • Change in Reasons for drinking at 3 months.

    Baseline, 3 months

  • +7 more secondary outcomes

Other Outcomes (4)

  • Intervention Acceptability

    3 months.

  • Intervention Fidelity

    3 months.

  • Participant Retention

    3 months.

  • +1 more other outcomes

Study Arms (2)

Treatment group

OTHER

The intervention group will receive individual PST (60 min individual sessions for 6 weeks, in addition to engaging with APPLE Watch features including fitness tracking (such as regular walks), heart rate, and sleep management on a daily basis. Throughout the final 6 individual self-engaged sessions, participants will persist in engaging and utilizing APPLE Watch features, incorporating daily fitness tracking (such as regular walks), wellness applications, and sleep management and apply PST.

Behavioral: PST-APPLE Watch group

Control group

OTHER

Participants assigned to Education-only control will be asked to watch "Quit Drinking Motivation," a 20-min video created by the MotivationHub. This video consists of a speech and conversation discussing the negative consequences resulting from their alcohol misuse and the importance of getting sober. The video will be followed by a 30-minute group discussion via zoom.

Behavioral: Education-only control group

Interventions

PST combined APPLE Watch is a tailored behavioral intervention that enables college students with AUD to successfully manage and overcome everyday life challenges influencing their alcohol intake and teach problem-solving skills.

Treatment group

Education-only control group receives Quit Drinking Motivation 20-min video created by the MotivationHub, followed by a 30-minute group discussion.

Control group

Eligibility Criteria

Age18 Years - 25 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Male and female college students aged 18-25 yr
  • English-speaking
  • Current alcohol use more than or equal to 2 days/week via phone screening
  • Completion of AUDIT screening and meet criteria for (past year) mild, moderate or severe AUD during AUDADIS-5 interview
  • Completion of written informed consent
  • Interested in cutting back alcohol intake or changing his/her drinking
  • Baseline screening study visit

You may not qualify if:

  • Participation in past 6 months in AUD or substance use treatment
  • Current use of medications used to treat AUD (e.g., naltrexone)
  • Lifetime Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 diagnosis of schizophrenia, bipolar disorder, or any psychotic disorder
  • Current use of psychoactive drugs
  • Not currently enrolled in college
  • Not interested in cutting back alcohol intake or changing his/her drinking
  • Pregnancy or intention to become pregnant

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Illinois at Chicago

Chicago, Illinois, 60608, United States

Location

MeSH Terms

Conditions

Alcoholism

Condition Hierarchy (Ancestors)

Alcohol-Related DisordersSubstance-Related DisordersChemically-Induced DisordersMental Disorders

Study Officials

  • Hallihan Hagar, PhD, RN

    Department of Medicine, University of Illinois at Chicago

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: PRO-APPLE Study is a 2-arm pilot Randomized Control Trial (RCT).
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Research Assistant Professor

Study Record Dates

First Submitted

March 20, 2024

First Posted

March 27, 2024

Study Start

April 15, 2024

Primary Completion

September 30, 2024

Study Completion

November 30, 2024

Last Updated

December 13, 2024

Record last verified: 2024-12

Data Sharing

IPD Sharing
Will share

We will adhere to the University of Illinois Chicago (UIC) Grant Policy on Sharing of Unique Research Resources including the Principles and Guidelines for Recipients of UIC Research Grants. Data from this research will be shared and the results of this research will be made available via publication in scientific journals and through scientific meetings where our findings are reported. Publication of data shall occur during the project, if appropriate, or at the end of the project, consistent with typical scientific practices. All publications will be made publicly available consistent with UIC policies.

Shared Documents
SAP, CSR
Time Frame
After analyzing.

Locations