A Genetic Study for Alzheimer Dementia: Case-control Study

NCT06330155 | Not Yet Recruiting

• 1 other identifier: 2024-01-032
• Study Type: observational
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to find out the difference in genetic test results between Alzheimer's dementia patients and healthy subjects. The investigators want to identify genes that are importantly related to Alzheimer's dementia.

Conditions

Alzheimer Dementia (AD)

Outcome Measures

Primary Outcomes (1)

• genetic analysis

  5cc blood collection for genetic testing

  Baseline

Secondary Outcomes (3)

• Measurement of Korean version of mini-mental state examination (K-MMSE)

  screening, Baseline

• Measurement of Clinical Dementia Rating (CDR)

  screening, Baseline

• Measurement of Geriatric Depression Scale (GDSd)

  Baseline

Study Arms (1)

Alzheimer's dementia patient and healthy subjects

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

10 Alzheimer's dementia patients 10 healthy subjects

You may qualify if:

• Adult patients over 60 years old
• Patients with a Alzheimer's dementia patient
• Total Korean version of mini-mental state examination (K-MMSE) score less than 24
• Total Clinical Dementia Rating (CDR) over 0.5
• Adult healthy over 60 years old
• Total Korean version of mini-mental state examination (K-MMSE) over 24
• Total Clinical Dementia Rating (CDR) is 0

You may not qualify if:

• Those with severe medical conditions such as unstable conditions of the cardiovascular system, digestive system, respiratory system, endocrine system, etc., who are in poor general condition
• In the case of a person with impaired consent (MMSE less than 10 points), if not accompanied by a guardian
• Other cases where the researcher determines that participation in this clinical trial is not appropriate (Patients who are participating in other studies or have participated in other studies within the past 30 days can also participate in this study.)

Sponsors & Collaborators

• MinYoung Kim, MD, PhD: lead

MeSH Terms

Conditions

Alzheimer Disease

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Study Officials

• MinYoung Kim, MD, PhD

  CHA Bundang Medical Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

MinYoung Kim, MD, PhD

CONTACT

82-31-780-6281; kmin@cha.ac.kr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Sponsor-Investigator

Study Record Dates

• First Submitted: March 19, 2024
• First Posted: March 26, 2024
• Study Start: March 26, 2024
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: April 4, 2024

Record last verified: 2024-04