Midkine Role With Deregulated Oxidative and Immune Milieu in Induction of Preeclampsia

NCT06329284 | Completed

• 1 other identifier: RC 31.1.2024
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Preeclampsia (PE) is a hypertensive pregnancy-related disorder that endangers maternal and fetal outcomes and accounts for 9-10% of maternal mortalities with its early-onset phenotype is the most dangerous, but its etiology is still not fully elucidated. Midkine (MDK) is a multifunctional protein that plays a unique role in the development of hypertension (HTN), via its proatherogenic effect and induction of overexpression of angiotensin converting enzyme. Oxidative stress (OS) upregulates the expression of MDK and MDK induces propagation of neoangiogenesis and acts as chemotactic for neutrophils.

Conditions

Pre-Eclampsia

Outcome Measures

Primary Outcomes (1)

• Severity of Pre-Eclampsia (PE)

  Correlation between Serum midkine levels and blood pressure measurements

  8 months

Study Arms (1)

Serum Midkine

OTHER

Diagnostic Test: ELISA

Interventions

ELISA DIAGNOSTIC_TEST

ELISA estimation of serum Midkine, tumor necrosis factor Alfa, superoxide dismutase, malondialdehyde, placental growth factor and placental soluble fms-like tyrosine kinase 1

Serum Midkine

Eligibility Criteria

• Age: 21 Years - 50 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Newly pregnant normotensive (NT) women with singleton fetus;

You may not qualify if:

• Women with history of complicated pregnancy;
• Had manifest essential hypertension, Diabetes Mellitus or chronic kidney diseases;
• Had multiple gestational sacs, morbid obesity with Body Mass Index at time of pregnancy diagnosis over 35 kg/m2;
• Had genetic disorders, coagulopathy, autoimmune diseases or maintained on immunosuppressive therapy.

Sponsors & Collaborators

• Benha University: lead

Study Sites (1)

Banha University

Banhā, El- Qalyobia, 13511, Egypt

Location

MeSH Terms

Conditions

Pre-Eclampsia

Condition Hierarchy (Ancestors)

Hypertension, Pregnancy-Induced; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Obstetrics & Gynecology, Faculty of Medicine

Model Details: Newly pregnant normotensive (NT) women with singleton fetus

Study Record Dates

• First Submitted: March 10, 2024
• First Posted: March 25, 2024
• Study Start: January 1, 2023
• Primary Completion: September 15, 2023
• Study Completion: December 15, 2023
• Last Updated: March 26, 2024

Record last verified: 2024-03

Locations

EG (1)