Otoacoustic Emissions in Different Blood Types

NCT06326866 | Completed

• 1 other identifier: E-74555795-050.04-941208
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this study is to examine whether ABO and Rhesus (Rh) blood group systems have an association with distortion product otoacoustic emission (DPOAE) and transient otoacoustic emission (TEOAE) amplitudes with the hypothesis of blood groups may affect hearing thresholds.

Conditions

Hearing Loss, Cochlear

Keywords

otoacoustic emissions; blood type

Outcome Measures

Primary Outcomes (1)

• Signal to noise ratios

  SNRs obtained for different frequencies in OAE In TEOAE, 1, 1.4, 2, 2.8, 4 kHz, in DPOAE 1, 1.4, 2, 2.8, 4, 6 kHz

  1 month

Study Arms (8)

Individuals with A Rh (+) blood group

Individuals with normal hearing and whose blood group was previously determined as A Rh (+) will be included and Transient evoked Otoacoustic Emissions (TOAE) and Distortion Product Otoacoustic Emissions (DPOAE) will be performed.

Diagnostic Test: Otoacoustic emissions (non-invasive)

Individuals with A Rh (-) blood group

Individuals with normal hearing and whose blood group was previously determined as A Rh (-) will be included and Transient evoked Otoacoustic Emissions (TOAE) and Distortion Product Otoacoustic Emissions (DPOAE) will be performed.

Diagnostic Test: Otoacoustic emissions (non-invasive)

Individuals with B Rh (+) blood group

Individuals with normal hearing and whose blood group was previously determined as B Rh (+) will be included and and Transient evoked Otoacoustic Emissions (TOAE) and Distortion Product Otoacoustic Emissions (DPOAE) will be performed.

Diagnostic Test: Otoacoustic emissions (non-invasive)

Individuals with B Rh (-) blood group

Individuals with normal hearing and whose blood group was previously determined as B Rh (-) will be included and and Transient evoked Otoacoustic Emissions (TOAE) and Distortion Product Otoacoustic Emissions (DPOAE) will be performed.

Diagnostic Test: Otoacoustic emissions (non-invasive)

Individuals with AB Rh (+) blood group

Individuals with normal hearing and whose blood group was previously determined as AB Rh (+) will be included and and Transient evoked Otoacoustic Emissions (TOAE) and Distortion Product Otoacoustic Emissions (DPOAE) will be performed.

Diagnostic Test: Otoacoustic emissions (non-invasive)

Individuals with AB Rh (-) blood group

Individuals with normal hearing and whose blood group was previously determined as AB Rh (-) will be included and and Transient evoked Otoacoustic Emissions (TOAE) and Distortion Product Otoacoustic Emissions (DPOAE) will be performed.

Diagnostic Test: Otoacoustic emissions (non-invasive)

Individuals with O Rh (+) blood group

Individuals with normal hearing and whose blood group was previously determined as O Rh (+) will be included and and Transient evoked Otoacoustic Emissions (TOAE) and Distortion Product Otoacoustic Emissions (DPOAE) will be performed.

Diagnostic Test: Otoacoustic emissions (non-invasive)

Individuals with O Rh (-) blood group

Individuals with normal hearing and whose blood group was previously determined as O Rh (-) will be included and and Transient evoked Otoacoustic Emissions (TOAE) and Distortion Product Otoacoustic Emissions (DPOAE) will be performed.

Diagnostic Test: Otoacoustic emissions (non-invasive)

Interventions

Otoacoustic emissions (non-invasive) DIAGNOSTIC_TEST

There is no invasive intervention in the study. Individuals with predetermined blood types will be included in the study.

Individuals with A Rh (+) blood group; Individuals with A Rh (-) blood group; Individuals with AB Rh (+) blood group; Individuals with AB Rh (-) blood group; Individuals with B Rh (+) blood group; Individuals with B Rh (-) blood group; Individuals with O Rh (+) blood group; Individuals with O Rh (-) blood group

Eligibility Criteria

• Age: 18 Years - 26 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Individuals between the ages of 18-26 with known blood type without hearing loss

You may qualify if:

• not having hearing loss
• having a blood group card obtained from health institutions

Sponsors & Collaborators

• Istanbul University - Cerrahpasa: lead

Study Sites (1)

Eyyup KARA

Istanbul, 34107, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Hearing Loss, Sensorineural

Interventions

Otoacoustic Emissions, Spontaneous

Condition Hierarchy (Ancestors)

Hearing Loss; Hearing Disorders; Ear Diseases; Otorhinolaryngologic Diseases; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Hearing; Vestibulocochlear Physiological Phenomena; Physiological Phenomena; Sensation; Nervous System Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Eyyup Kara, PhD

  Istanbul University - Cerrahpasa

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: March 18, 2024
• First Posted: March 22, 2024
• Study Start: February 7, 2024
• Primary Completion: March 12, 2024
• Study Completion: March 18, 2024
• Last Updated: March 26, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)