Gap CO2 in Septic Patient to Predict Cardiomyopathy Septic

NCT06326762 | Completed

• 1 other identifier: younes
• Study Type: observational
• Target: 98
• Locations: 1 country
• Sites: 1

Brief Summary

the investigators included 98 patients admitted for sepsis and septic shock (68.4% men, 31.6% women) with an average age of 60.42 years ± 15.13, ranging from 21 to 96 years. The average length of hospital stay was 7.53 days. The most noted medical histories were diabetes (38.8%), hypertension (28.6%), and renal insufficiency (17.1%). Regarding laboratory findings: the mean white blood cell count was 15,985.16 cells/mm³, the mean C-reactive protein (CRP) level was 227.69 mg/L, and the mean procalcitonin level was 50.43 µg/L. In terms of blood gas analysis: the mean lactate level was 3.67 mmol/L, and the mean PCO2 gap (DELTAPCO2) was 4.85. All our patients were continuously monitored by pulse wave analysis: the mean cardiac output was 5.69 L/min, and the mean cardiac index was 4.14 L/s/m² All our patients underwent an echocardiogram, which is a routine examination in our department and is performed at the patient's bedside. The average left ventricular ejection fraction (LVEF) was 51.73%, and the average subaortic peak velocity (ITV) was 14.66 cm. Subsequently. the investigators examined the clinical and paraclinical profile of patients with septic cardiomyopathy. the investigators identified 19 patients with this condition, while 79 patients did not exhibit cardiac involvement. The percentage was significantly higher in the population with cardiac involvement, accounting for 28.3%. Among the patients with cardiac involvement, 76.5% had a PCO2 gap (DELTAPCO2) ≥ 6 mmHg, a significantly reduced cardiac output with an average of 3.3 L/min, and a predominantly low cardiac index, with 64.3% having an index \< 2.2 L/min/m². The mortality rate was significantly increased at 73.7%.

Conditions

Gap co2; Cardiac Output, Low; Cardiac Defect

Keywords

cardiac; CO2; septic

Outcome Measures

Primary Outcomes (1)

• gapCO2

  significative in cardiomyopathy septic

  10 mounths

Study Arms (2)

Myocardial Dysfunction

Other: comparaison

No Myocardial Dysfunction

Other: comparaison

Interventions

comparaison OTHER

description indicate

Myocardial Dysfunction; No Myocardial Dysfunction

Eligibility Criteria

• Age: 18 Years+
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

We included patients diagnosed with sepsis/septic shock admitted at various points in time to the intensive care units of the Mohammed VI University Hospital in Oujda.

You may qualify if:

• Patients admitted to the intensive care unit
• sepsis or septic shock
• at least one echocardiogram and were monitored by pulse wave contour analysis
• stay of 72 hours in the intensive care unit

You may not qualify if:

• Patients without sepsis or septic shock.
• Patients with COVID-19.
• Patients who died within 48 hours of hospitalization.
• Cases with incomplete medical records or patients not monitored.
• Patient with pre-existing cardiac conditions.
• post-operative patients from cardiac and thoracic surgeries.

Sponsors & Collaborators

• Mohammed VI University Hospital: lead

Study Sites (1)

younes Oujidi

Berkane, 9999, Morocco

Location

MeSH Terms

Conditions

Cardiac Output, Low

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: doctor

Study Record Dates

• First Submitted: March 3, 2024
• First Posted: March 22, 2024
• Study Start: January 1, 2023
• Primary Completion: October 30, 2023
• Study Completion: October 30, 2023
• Last Updated: March 22, 2024

Record last verified: 2024-03

Locations

MO (1)