NCT06325267

Brief Summary

Primary liver cancer (PLC) is the sixth most common malignancy in the world and the third most common cause of malignancy death. In 2020, there were about 905,677 new cases of PLC worldwide, and 830,180 deaths. Despite the availability of a variety of treatments for PLC, the 5-year net survival rate is still only 5% to 30%. How to effectively reduce the disease burden of PLC is a major public health problem that needs to be solved worldwide. The clinical characteristics and prognosis of PLC caused by different pathogenic factors are different. Therefore, it is of great significance to fully identify the risk factors of PLC, be familiar with the clinical characteristics and prognosis of disease development, and understand the relevant monitoring and follow-up strategies for the prevention and treatment of PLC.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
1,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2010

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2010

Completed
14.2 years until next milestone

First Submitted

Initial submission to the registry

March 15, 2024

Completed
7 days until next milestone

First Posted

Study publicly available on registry

March 22, 2024

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 31, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2024

Completed
Last Updated

March 27, 2024

Status Verified

March 1, 2024

Enrollment Period

14.7 years

First QC Date

March 15, 2024

Last Update Submit

March 25, 2024

Conditions

Keywords

primary liver cancerclinical features

Outcome Measures

Primary Outcomes (2)

  • Epidemiological characteristics of overall cohort by liver disease etiology

    Epidemiological characteristics of overall cohort by liver disease etiology, including HBV, HCV, NAFLD, ALD and others.

    0 year

  • Clinical characteristics of overall cohort by liver disease etiology

    Clinical characteristics of overall cohort by liver disease etiology, including HBV, HCV, NAFLD, ALD and others.

    0 year

Secondary Outcomes (2)

  • Survival rates of overall cohort and different etiologies

    1 year, 3years,10 years

  • Risk factors of prognosis in overall cohort and different etiologies

    10 years

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

primary liver cancer

You may qualify if:

  • years or older;
  • initial diagnosis of primary liver cancer based on enhanced CT or enhanced MRI or pathology

You may not qualify if:

  • other types of malignant tumors;
  • mental illness, severe cardiopulmonary dysfunction, severe renal insufficiency, serious infection and cerebrovascular accident;
  • received liver transplant or other organ transplant.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Nanjing Drum Tower Hospital

Nanjing, Jiangsu, 210008, China

RECRUITING

MeSH Terms

Conditions

Carcinoma, Hepatocellular

Condition Hierarchy (Ancestors)

AdenocarcinomaCarcinomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeNeoplasmsLiver NeoplasmsDigestive System NeoplasmsNeoplasms by SiteDigestive System DiseasesLiver Diseases

Central Study Contacts

Jie Li, M.D.,Ph.D

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal investigator

Study Record Dates

First Submitted

March 15, 2024

First Posted

March 22, 2024

Study Start

January 1, 2010

Primary Completion

August 31, 2024

Study Completion

August 31, 2024

Last Updated

March 27, 2024

Record last verified: 2024-03

Locations