Primary Liver Cancer Cohort of South China

NCT03297255 | Unknown

• 1 other identifier: SYS-2013
• Study Type: observational
• Target: 4,000
• Locations: 1 country
• Sites: 1

Brief Summary

This longitudinal observational cohort study was designed to investigate factors that influencing the occurrence and long-term survival of patients with primary liver cancer. Basic informations and detailed diagnosis informations (AJCC/TNM stage, MELD score, Child-Pugh score, and BCLC stage) were collected by professional doctors. Clinical outcomes (death, recurrence, and metastasis) will be followed up every two years after therapy.

Conditions

Primary Liver Cancer

Keywords

Primary Liver Cancer; Cohort Study

Outcome Measures

Primary Outcomes (1)

• Time of Death

  The exact death time of each participants will be checked in the government medical records system

  Up to 10 years

Secondary Outcomes (2)

• Time of recurrence

  From date of diagnosis until the date of cancer recurrence or date of death from any cause, whichever came first, assessed up to 10 years

• Time of metastasis

  From date of diagnosis until the date of cancer metastasis or date of death from any cause, whichever came first, assessed up to 10 years

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients of this study were invited from Sun Yat-sen University Cancer Center as soon as they were diagnosed as primary liver cancer

You may qualify if:

• age 18-80 years
• consistent with primary liver cancer diagnostic criteria
• first diagnosis (from diagnosis to admission interval of less than a month)
• did not do any treatment of liver cancer

You may not qualify if:

• refused to participate in this study
• suffering from more than two kinds of primary tumors

Sponsors & Collaborators

• Huilian Zhu: lead

Study Sites (1)

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, 510000, China

RECRUITING

Related Publications (2)

• Liu ZY, Yishake D, Fang AP, Zhang DM, Liao GC, Tan XY, Zhang YJ, Zhu HL. Serum choline is associated with hepatocellular carcinoma survival: a prospective cohort study. Nutr Metab (Lond). 2020 Mar 30;17:25. doi: 10.1186/s12986-020-00445-z. eCollection 2020.

  PMID: 32256673 DERIVED

• Liu ZY, Tan XY, Li QJ, Liao GC, Fang AP, Zhang DM, Chen PY, Wang XY, Luo Y, Long JA, Zhong RH, Zhu HL. Trimethylamine N-oxide, a gut microbiota-dependent metabolite of choline, is positively associated with the risk of primary liver cancer: a case-control study. Nutr Metab (Lond). 2018 Nov 20;15:81. doi: 10.1186/s12986-018-0319-2. eCollection 2018.

  PMID: 30479648 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Blood and liver tissue were retented during therapy

MeSH Terms

Conditions

Carcinoma, Hepatocellular

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Liver Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Digestive System Diseases; Liver Diseases

Study Officials

• Zhu Huilian, Professor

  Sun Yat-sen University

  STUDY CHAIR

Central Study Contacts

Zhu Huilian, Professor

CONTACT

+86 20 87331811; zhuhl@mail.sysu.edu.cn

Fang Aiping

CONTACT

020-87335875; fangaip@mail.sysu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 25, 2017
• First Posted: September 29, 2017
• Study Start: January 1, 2013
• Primary Completion: December 1, 2025
• Study Completion: December 1, 2025
• Last Updated: September 29, 2017

Record last verified: 2017-09

Locations

CN (1)