Weaning Ventilator Using Heart, Lung And Diaphragm Ultrasound

NCT06321848 | Recruiting DMC

• 1 other identifier: DUCGM2426
• Study Type: observational
• Target: 190
• Locations: 1 country
• Sites: 1

Brief Summary

Postextubation distress is detrimental to the prognosis of critically ill patients with successful spontaneous breathing trial. Failure to wean is known to be connected with heart, lung, and diaphragm problems. The aim of this study was to investigate how a composite model comprising diaphragm, lung, and heart ultrasonography indications could predict the weaning outcome. Methods: Ultrasonic features of the diaphragm, heart, and lungs are going to be collected along with clinical data about the patients. Either the successful weaning group or the failed weaning group is going to comprised the patients. Multivariate logistic regression analysis is going to be used to identify the variables that may be associated with the likelihood of weaning failure. A multiindicator combination model is going to be developed to increase the predictive accuracy after the possible indicators' accuracy in foretelling the weaning outcome was assessed.

Conditions

Ventilator Weaning; Ultrasound

Keywords

echocardiography; lung ultrasound; diaphragm ultrasound; ventilator weaning

Outcome Measures

Primary Outcomes (1)

• The ventilator weaning outcome

  The outcome of weaning ventilation process (successful or failure)

  after 48 hours of extubation

Secondary Outcomes (3)

• The hospital length of stay

  Approximately 5-15 days postextubation

• The ICU length of stay

  Approximately 2-15 days postextubation

• The duration of mechanical ventilation

  Daily assessment of requirement of mechanical ventilation from the time of intubation until the date of weaning mechanical ventilation, up to 12 months

Study Arms (1)

The ventilator weaning patients

Patients who have been on mechanical breathing for longer than 48 hours using an endotracheal tube and who fit the requirements to be weaned off of it

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients with a duration of mechanical ventilation through an endotracheal tube of more than 48 hours and meeting the criteria of readiness to wean off mechanical ventilation will be included in the study.

You may qualify if:

• Age \>= 18
• The duration of postoperative mechanical ventilation \>= 48 hours

You may not qualify if:

• Patient had a diagnosis of progressive neuromuscular diseases
• Patient had a history of cardiovascular or respiratory disease who depend on a ventilator at home (COPD, severe bronchial asthma)
• Patients had thoracic surgery or mitral valve surgery.

Sponsors & Collaborators

• Hanoi Medical University: lead

Study Sites (1)

Hanoi Medical University Hospital

Hanoi, 100000, Vietnam

RECRUITING

Study Officials

• Tu Nguyen, Professor

  Hanoi Medical University

  STUDY DIRECTOR

Central Study Contacts

Duc Tran, MD

CONTACT

+84983817388; ductran.hmu@gmail.com

Phuong Vu, MD, PhD

CONTACT

+84912300978; vuhoangphuong@hmu.edu.vn

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Target Duration: 30 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 27, 2024
• First Posted: March 20, 2024
• Study Start: April 22, 2024
• Primary Completion: March 1, 2026
• Study Completion: April 1, 2026
• Last Updated: February 3, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF, CSR
• Time Frame: from March 2026 to the unidentified time
• Access Criteria: anesthesiologists all over the world

Locations

VN (1)