NCT06311383

Brief Summary

This is a non-interventional observational study conducted in Germany to evaluate the real-world effectiveness, tolerability, safety, and quality of life in patients with locally advanced/metastatic HR+/HER2- breast cancer treated with one of the following 1st line treatments: Ribociclib + AI/FUL, or endocrine monotherapy, or chemotherapy

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,610

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Oct 2017

Longer than P75 for all trials

Geographic Reach
1 country

265 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 9, 2017

Completed
6.2 years until next milestone

First Submitted

Initial submission to the registry

December 29, 2023

Completed
3 months until next milestone

First Posted

Study publicly available on registry

March 15, 2024

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 10, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 10, 2025

Completed
Last Updated

January 27, 2026

Status Verified

January 1, 2026

Enrollment Period

7.4 years

First QC Date

December 29, 2023

Last Update Submit

January 23, 2026

Conditions

Keywords

Breast CancerNISRibociclibMetastatic Breast CancerHR+HER2-Real World Evidence

Outcome Measures

Primary Outcomes (1)

  • Progression-free survival (PFS)

    Progression-free survival was defined as first intake of study medication in current-line therapy up to first documented progress or death from any cause in this treatment line. If a patient had not had an event, progression-free survival was censored at the end of the respective therapy line.

    Up to 88 months

Secondary Outcomes (13)

  • Sequential progression-free survival (PFS_S)

    Up to 88 months

  • Time to treatment failure (TTF)

    Up to 88 months

  • Time to first chemotherapy

    Up to 88 months

  • Time to next treatment / therapy (TTNT) after 1st line treatment

    Up to 88 months

  • Overall survival (OS)

    Up to 88 months

  • +8 more secondary outcomes

Study Arms (3)

First-line Ribociclib + endocrine therapy

Ribociclib + letrozole, or Ribociclib + anastrozole, or Ribociclib + exemestane, or Ribociclib + fulvestrant

Drug: First-line Ribociclib + endocrine therapy

First-line endocrine therapy

As of physicians choice

Drug: First-line endocrine therapy

First-line chemotherapy

As of physicians choice

Drug: First-line chemtherapy

Interventions

Ribociclib + letrozole, or Ribociclib + anastrazole, or Ribociclib + exemestane, or Ribociclib + fulvestrant

First-line Ribociclib + endocrine therapy

As of physicians choice

First-line endocrine therapy

As of physicians choice

First-line chemotherapy

Eligibility Criteria

Age18 Years - 100 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adult females with HR+/HER2- locally advanced/metastatic breast cancer (progressed following prior therapy or de novo). Hereby locally advanced is defined by the following criteria (at least one must apply): tumor size \> 5 cm (T3), skin or chest wall infiltration (T4a, T4b), inflammatory breast cancer (T4c), fixed axilla-located lymph node conglomerate or intraclavicular lymph node metastasis (cN3; German S3 guideline for early detection, diagnosis, therapy and follow-up care of breast cancer; Version 4.1.2018). Patients are classified as therapy naïve for locally advanced/metastatic disease if they have not yet received a systemic therapy in the palliative setting. Patients with locally advanced breast cancer who have received therapy-(lines) in the adjuvant/curative setting are eligible after progression to e.g. a metastatic breast cancer. All patients who already received a palliative therapy for locally advanced/metastatic breast cancer are excluded from study participation.

You may qualify if:

  • Patients with a histological diagnosis of locally advanced/metastatic HR+/HER2- breast cancer. Histological diagnosis does not necessarily origin from metastasis, but must reflect the most recent disease status
  • No prior systemic treatment for locally advanced/metastatic disease in the palliative setting
  • The treating physician has made the decision to treat the patient
  • with ribociclib in combination with an aromatase inhibitor or fulvestrant as initial treatment in first line, or
  • endocrine therapy as initial treatment in first line (e.g. letrozole, anastrozole, fulvestrant), or
  • chemotherapy as initial treatment in first line (e.g. taxanes, capecitabine, with or without bevacizumab)
  • Written informed consent of the patient
  • Patient who initiated treatment for first line no longer than 4 weeks (28 days) prior to written informed consent for this study
  • Planned treatment is in line with the respective current German SmPC ("Summary of product characteristics")
  • Patient is ≥18 years

You may not qualify if:

  • Patients unable to provide written informed consent
  • Contra-indication according to the respective current German SmPC ("Summary of product characteristics"), as judged by the treating physician
  • The patient is currently under active treatment in an investigational study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (265)

Novartis Investigative Site

Baden-Baden, Baden-Wurttemberg, 76532, Germany

Location

Novartis Investigative Site

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany

Location

Novartis Investigative Site

Freudenstadt, Baden-Wurttemberg, 72250, Germany

Location

Novartis Investigative Site

Heidenheim, Baden-Wurttemberg, 89522, Germany

Location

Novartis Investigative Site

Karlsruhe, Baden-Wurttemberg, 76199, Germany

Location

Novartis Investigative Site

Mannheim, Baden-Wurttemberg, 68161, Germany

Location

Novartis Investigative Site

Mannheim, Baden-Wurttemberg, 68165, Germany

Location

Novartis Investigative Site

Mutlangen, Baden-Wurttemberg, 73557, Germany

Location

Novartis Investigative Site

Nürtingen, Baden-Wurttemberg, 72622, Germany

Location

Novartis Investigative Site

Ostfildern, Baden-Wurttemberg, 73760, Germany

Location

Novartis Investigative Site

Pforzheim, Baden-Wurttemberg, 75175, Germany

Location

Novartis Investigative Site

Reutlingen, Baden-Wurttemberg, 72764, Germany

Location

Novartis Investigative Site

Rottweil, Baden-Wurttemberg, 78628, Germany

Location

Novartis Investigative Site

Schwäbisch Hall, Baden-Wurttemberg, 74523, Germany

Location

Novartis Investigative Site

Sigmaringen, Baden-Wurttemberg, 72488, Germany

Location

Novartis Investigative Site

Winnenden, Baden-Wurttemberg, 71364, Germany

Location

Novartis Investigative Site

Altötting, Bavaria, 84503, Germany

Location

Novartis Investigative Site

Amberg, Bavaria, 92224, Germany

Location

Novartis Investigative Site

Ansbach, Bavaria, 91522, Germany

Location

Novartis Investigative Site

Aschaffenburg, Bavaria, 63739, Germany

Location

Novartis Investigative Site

Augsburg, Bavaria, 86152, Germany

Location

Novartis Investigative Site

Bamberg, Bavaria, 96052, Germany

Location

Novartis Investigative Site

Bayreuth, Bavaria, 95445, Germany

Location

Novartis Investigative Site

Donauwörth, Bavaria, 86609, Germany

Location

Novartis Investigative Site

Ebersberg, Bavaria, 85560, Germany

Location

Novartis Investigative Site

Eggenfelden, Bavaria, 84307, Germany

Location

Novartis Investigative Site

Kempten (Allgäu), Bavaria, 87439, Germany

Location

Novartis Investigative Site

Kronach, Bavaria, 96317, Germany

Location

Novartis Investigative Site

Krumbach, Bavaria, 86381, Germany

Location

Novartis Investigative Site

Landshut, Bavaria, 84036, Germany

Location

Novartis Investigative Site

Munich, Bavaria, 80639, Germany

Location

Novartis Investigative Site

Munich, Bavaria, 81241, Germany

Location

Novartis Investigative Site

Munich, Bavaria, 81925, Germany

Location

Novartis Investigative Site

Nuremberg, Bavaria, 90409, Germany

Location

Novartis Investigative Site

Regensburg, Bavaria, 93053, Germany

Location

Novartis Investigative Site

Straubing, Bavaria, 94315, Germany

Location

Novartis Investigative Site

Würzburg, Bavaria, 97070, Germany

Location

Novartis Investigative Site

Würzburg, Bavaria, 97080, Germany

Location

Novartis Investigative Site

Mannheim, Beden Wuerttenberg, 68167, Germany

Location

Novartis Investigative Site

Brandenburg, Brandenburg, 14770, Germany

Location

Novartis Investigative Site

Cottbus, Brandenburg, 03048, Germany

Location

Novartis Investigative Site

Doberlug-Kirchhain, Brandenburg, 03253, Germany

Location

Novartis Investigative Site

Fürstenwalde, Brandenburg, 15517, Germany

Location

Novartis Investigative Site

Ludwigsfelde, Brandenburg, 14974, Germany

Location

Novartis Investigative Site

Spremberg, Brandenburg, 03130, Germany

Location

Novartis Investigative Site

Bremen, City state Bremen, 28209, Germany

Location

Novartis Investigative Site

Bremen, City state Bremen, 28239, Germany

Location

Novartis Investigative Site

Bremerhaven, City state Bremen, 27576, Germany

Location

Novartis Investigative Site

Schwerte, Germany, 58239, Germany

Location

Novartis Investigative Site

Wiesbaden, Germany, 65191, Germany

Location

Novartis Investigative Site

Hamburg, Hamburg, 22087, Germany

Location

Novartis Investigative Site

Hamburg, Hamburg, 22291, Germany

Location

Novartis Investigative Site

Hamburg, Hamburg, 22457, Germany

Location

Novartis Investigative Site

Bad Homburg, Hesse, 61352, Germany

Location

Novartis Investigative Site

Bad Nauheim, Hesse, 61231, Germany

Location

Novartis Investigative Site

Darmstadt, Hesse, 64283, Germany

Location

Novartis Investigative Site

Erbach im Odenwald, Hesse, 64711, Germany

Location

Novartis Investigative Site

Frankfurt am Main, Hesse, 60398, Germany

Location

Novartis Investigative Site

Frankfurt am Main, Hesse, 60431, Germany

Location

Novartis Investigative Site

Frankfurt am Main, Hesse, 65929, Germany

Location

Novartis Investigative Site

Langen, Hesse, 63225, Germany

Location

Novartis Investigative Site

Lich, Hesse, 35423, Germany

Location

Novartis Investigative Site

Marburg, Hesse, 35043, Germany

Location

Novartis Investigative Site

Braunschweig, Lower Saxony, 38100, Germany

Location

Novartis Investigative Site

Buchholz, Lower Saxony, 21244, Germany

Location

Novartis Investigative Site

Damme, Lower Saxony, 49401, Germany

Location

Novartis Investigative Site

Georgsmarienhütte, Lower Saxony, 49124, Germany

Location

Novartis Investigative Site

Hamelin, Lower Saxony, 31785, Germany

Location

Novartis Investigative Site

Hanover, Lower Saxony, 30171, Germany

Location

Novartis Investigative Site

Hildesheim, Lower Saxony, 31134, Germany

Location

Novartis Investigative Site

Ilsede, Lower Saxony, 31241, Germany

Location

Novartis Investigative Site

Lingen Ems, Lower Saxony, 49808, Germany

Location

Novartis Investigative Site

Osnabrück, Lower Saxony, 49076, Germany

Location

Novartis Investigative Site

Rotenburg (Wümme), Lower Saxony, 27356, Germany

Location

Novartis Investigative Site

Twistringen, Lower Saxony, 27239, Germany

Location

Novartis Investigative Site

Westerstede, Lower Saxony, 26655, Germany

Location

Novartis Investigative Site

Wolfenbüttel, Lower Saxony, 38304, Germany

Location

Novartis Investigative Site

Neubrandenburg, Mecklenburg-Vorpommern, 17036, Germany

Location

Novartis Investigative Site

Rostock, Mecklenburg-Vorpommern, 18057, Germany

Location

Novartis Investigative Site

Schwerin, Mecklenburg-Vorpommern, 19059, Germany

Location

Novartis Investigative Site

Stralsund, Mecklenburg-Vorpommern, 18435, Germany

Location

Novartis Investigative Site

Arnsberg, North Rhine-Westphalia, 59759, Germany

Location

Novartis Investigative Site

Bergisch Gladbach, North Rhine-Westphalia, 51465, Germany

Location

Novartis Investigative Site

Bielefeld, North Rhine-Westphalia, 33611, Germany

Location

Novartis Investigative Site

Bielefeld, North Rhine-Westphalia, 33615, Germany

Location

Novartis Investigative Site

Bochum, North Rhine-Westphalia, 44787, Germany

Location

Novartis Investigative Site

Bonn, North Rhine-Westphalia, 53113, Germany

Location

Novartis Investigative Site

Bonn, North Rhine-Westphalia, 53177, Germany

Location

Novartis Investigative Site

Cologne, North Rhine-Westphalia, 50179, Germany

Location

Novartis Investigative Site

Cologne, North Rhine-Westphalia, 50937, Germany

Location

Novartis Investigative Site

Dortmund, North Rhine-Westphalia, 44137, Germany

Location

Novartis Investigative Site

Dortmund, North Rhine-Westphalia, 44309, Germany

Location

Novartis Investigative Site

Düsseldorf, North Rhine-Westphalia, 40325, Germany

Location

Novartis Investigative Site

Düsseldorf, North Rhine-Westphalia, 40625, Germany

Location

Novartis Investigative Site

Gelsenkirchen, North Rhine-Westphalia, 45879, Germany

Location

Novartis Investigative Site

Hagen, North Rhine-Westphalia, 58089, Germany

Location

Novartis Investigative Site

Herdecke, North Rhine-Westphalia, 58313, Germany

Location

Novartis Investigative Site

Herne, North Rhine-Westphalia, 44649, Germany

Location

Novartis Investigative Site

Hilden, North Rhine-Westphalia, 40724, Germany

Location

Novartis Investigative Site

Krefeld, North Rhine-Westphalia, 47805, Germany

Location

Novartis Investigative Site

Lemgo, North Rhine-Westphalia, 32657, Germany

Location

Novartis Investigative Site

Mönchengladbach, North Rhine-Westphalia, 41061, Germany

Location

Novartis Investigative Site

Olpe, North Rhine-Westphalia, 57462, Germany

Location

Novartis Investigative Site

Paderborn, North Rhine-Westphalia, 33098, Germany

Location

Novartis Investigative Site

Remscheid, North Rhine-Westphalia, 42853, Germany

Location

Novartis Investigative Site

Remscheid, North Rhine-Westphalia, 42859, Germany

Location

Novartis Investigative Site

Siegen, North Rhine-Westphalia, 57072, Germany

Location

Novartis Investigative Site

Troisdorf, North Rhine-Westphalia, 53840, Germany

Location

Novartis Investigative Site

Velbert, North Rhine-Westphalia, 42551, Germany

Location

Novartis Investigative Site

Wesel, North Rhine-Westphalia, 46483, Germany

Location

Novartis Investigative Site

Wesel, North Rhine-Westphalia, 46485, Germany

Location

Novartis Investigative Site

Witten, North Rhine-Westphalia, 58455, Germany

Location

Novartis Investigative Site

Mayen, Rhineland-Palatinate, 56727, Germany

Location

Novartis Investigative Site

Neustadt an der Weinstraße, Rhineland-Palatinate, 67434, Germany

Location

Novartis Investigative Site

Simmern, Rhineland-Palatinate, 55469, Germany

Location

Novartis Investigative Site

Lebach, Saarland, 66822, Germany

Location

Novartis Investigative Site

Dresden, Saxony, 01127, Germany

Location

Novartis Investigative Site

Dresden, Saxony, 01307, Germany

Location

Novartis Investigative Site

Leipzig, Saxony, 04103, Germany

Location

Novartis Investigative Site

Leipzig, Saxony, 04129, Germany

Location

Novartis Investigative Site

Lohsa-Weisskollm, Saxony, 02999, Germany

Location

Novartis Investigative Site

Neustadt in Sachsen, Saxony, 01844, Germany

Location

Novartis Investigative Site

Pirna, Saxony, 01796, Germany

Location

Novartis Investigative Site

Plauen, Saxony, 08525, Germany

Location

Novartis Investigative Site

Rodewisch, Saxony, 08228, Germany

Location

Novartis Investigative Site

Scheibenberg, Saxony, 09481, Germany

Location

Novartis Investigative Site

Schkeuditz, Saxony, 04435, Germany

Location

Novartis Investigative Site

Zittau, Saxony, 02763, Germany

Location

Novartis Investigative Site

Zxickau, Saxony, 08060, Germany

Location

Novartis Investigative Site

Halle, Saxony-Anhalt, 06110, Germany

Location

Novartis Investigative Site

Magdeburg, Saxony-Anhalt, 39108, Germany

Location

Novartis Investigative Site

Magdeburg, Saxony-Anhalt, 39130, Germany

Location

Novartis Investigative Site

Quedlinburg, Saxony-Anhalt, 06484, Germany

Location

Novartis Investigative Site

Flensburg, Schleswig-Holstein, 24939, Germany

Location

Novartis Investigative Site

Lübeck, Schleswig-Holstein, 23563, Germany

Location

Novartis Investigative Site

Berlin, State of Berlin, 10117, Germany

Location

Novartis Investigative Site

Berlin, State of Berlin, 10317, Germany

Location

Novartis Investigative Site

Berlin, State of Berlin, 13187, Germany

Location

Novartis Investigative Site

Berlin, State of Berlin, 14197, Germany

Location

Novartis Investigative Site

Apolda, Thuringia, 99510, Germany

Location

Novartis Investigative Site

Eisenach, Thuringia, 99817, Germany

Location

Novartis Investigative Site

Erfurt, Thuringia, 99084, Germany

Location

Novartis Investigative Site

Jena, Thuringia, 07740, Germany

Location

Novartis Investigative Site

Meiningen, Thuringia, 98617, Germany

Location

Novartis Investigative Site

Mühlhausen, Thuringia, 99974, Germany

Location

Novartis Investigative Site

Nordhausen, Thuringia, 99734, Germany

Location

Novartis Investigative Site

Suhl, Thuringia, 98527, Germany

Location

Novartis Investigative Site

Altötting, 84503, Germany

Location

Novartis Investigative Site

Augsburg, 86150, Germany

Location

Novartis Investigative Site

Augsburg, 86179, Germany

Location

Novartis Investigative Site

Bad Liebenwerda, 04924, Germany

Location

Novartis Investigative Site

Bamberg, 96049, Germany

Location

Novartis Investigative Site

Bayreuth, 95445, Germany

Location

Novartis Investigative Site

Berlin, 10715, Germany

Location

Novartis Investigative Site

Berlin, 12487, Germany

Location

Novartis Investigative Site

Berlin, 13353, Germany

Location

Novartis Investigative Site

Berlin, 13581, Germany

Location

Novartis Investigative Site

Berlin, 14169, Germany

Location

Novartis Investigative Site

Bochum, 44791, Germany

Location

Novartis Investigative Site

Bonn, 53111, Germany

Location

Novartis Investigative Site

Bonn, 53113, Germany

Location

Novartis Investigative Site

Bottrop, 46236, Germany

Location

Novartis Investigative Site

Böblingen, 71032, Germany

Location

Novartis Investigative Site

Brandenburg, 14770, Germany

Location

Novartis Investigative Site

Bremen, 28205, Germany

Location

Novartis Investigative Site

Bremerhaven, 27574, Germany

Location

Novartis Investigative Site

Celle, 29223, Germany

Location

Novartis Investigative Site

Chemnitz, 09113, Germany

Location

Novartis Investigative Site

Chemnitz, 09117, Germany

Location

Novartis Investigative Site

Cologne, 50671, Germany

Location

Novartis Investigative Site

Cologne, 50935, Germany

Location

Novartis Investigative Site

Cologne, 51067, Germany

Location

Novartis Investigative Site

Dessau, 06847, Germany

Location

Novartis Investigative Site

Dresden, 01307, Germany

Location

Novartis Investigative Site

Erfurt, 99084, Germany

Location

Novartis Investigative Site

Erlangen, 91054, Germany

Location

Novartis Investigative Site

Essen, 45147, Germany

Location

Novartis Investigative Site

Esslingen am Neckar, 73730, Germany

Location

Novartis Investigative Site

Eutin, 23701, Germany

Location

Novartis Investigative Site

Friedberg, 86316, Germany

Location

Novartis Investigative Site

Friedrichshafen, 88045, Germany

Location

Novartis Investigative Site

Gera, 07548, Germany

Location

Novartis Investigative Site

Goch, 47574, Germany

Location

Novartis Investigative Site

Goslar, 38642, Germany

Location

Novartis Investigative Site

Göttingen, 37073, Germany

Location

Novartis Investigative Site

Göttingen, 37075, Germany

Location

Novartis Investigative Site

Greifswald, 17475, Germany

Location

Novartis Investigative Site

Gummersbach, 51643, Germany

Location

Novartis Investigative Site

Halberstadt, 38820, Germany

Location

Novartis Investigative Site

Hamburg, 20259, Germany

Location

Novartis Investigative Site

Hamburg, 20357, Germany

Location

Novartis Investigative Site

Hamburg, 22081, Germany

Location

Novartis Investigative Site

Hamelin, 31785, Germany

Location

Novartis Investigative Site

Hanau, 63450, Germany

Location

Novartis Investigative Site

Hanover, 30161, Germany

Location

Novartis Investigative Site

Hanover, 30177, Germany

Location

Novartis Investigative Site

Hanover, 30625, Germany

Location

Novartis Investigative Site

Hof, 95028, Germany

Location

Novartis Investigative Site

Homburg, 66421, Germany

Location

Novartis Investigative Site

Kaiserslautern, 67655, Germany

Location

Novartis Investigative Site

Karlsruhe, 76133, Germany

Location

Novartis Investigative Site

Karlsruhe, 76135, Germany

Location

Novartis Investigative Site

Kassel, 34119, Germany

Location

Novartis Investigative Site

Kiel, 24105, Germany

Location

Novartis Investigative Site

Koblenz, 56068, Germany

Location

Novartis Investigative Site

Kulmbach, 95326, Germany

Location

Novartis Investigative Site

Leipzig, 04277, Germany

Location

Novartis Investigative Site

Loerrach, 79539, Germany

Location

Novartis Investigative Site

Lübeck, 23538, Germany

Location

Novartis Investigative Site

Mainz, 55131, Germany

Location

Novartis Investigative Site

Marburg, 35037, Germany

Location

Novartis Investigative Site

Marktredwitz, 95615, Germany

Location

Novartis Investigative Site

Memmingen, 87700, Germany

Location

Novartis Investigative Site

Minden, 32429, Germany

Location

Novartis Investigative Site

Moers, 47441, Germany

Location

Novartis Investigative Site

Münster, 48145, Germany

Location

Novartis Investigative Site

Naunhof, 04683, Germany

Location

Novartis Investigative Site

Neuruppin, 16816, Germany

Location

Novartis Investigative Site

Neuss, 41462, Germany

Location

Novartis Investigative Site

Neuss, 41464, Germany

Location

Novartis Investigative Site

Nuremberg, 90419, Germany

Location

Novartis Investigative Site

Nuremberg, 90449, Germany

Location

Novartis Investigative Site

Offenbach, 63069, Germany

Location

Novartis Investigative Site

Offenburg, 77654, Germany

Location

Novartis Investigative Site

Oldenburg, 26121, Germany

Location

Novartis Investigative Site

Osnabrück, 49076, Germany

Location

Novartis Investigative Site

Passau, 94036, Germany

Location

Novartis Investigative Site

Potsdam, 14467, Germany

Location

Novartis Investigative Site

Ravensburg, 88214, Germany

Location

Novartis Investigative Site

Regensburg, 93053, Germany

Location

Novartis Investigative Site

Rheine, 48431, Germany

Location

Novartis Investigative Site

Rodgau, 63110, Germany

Location

Novartis Investigative Site

Rosenheim, 83022, Germany

Location

Novartis Investigative Site

Rostock, 18059, Germany

Location

Novartis Investigative Site

Rüsselsheim am Main, 65428, Germany

Location

Novartis Investigative Site

Saarbrücken, 66113, Germany

Location

Novartis Investigative Site

Saarlouis, 66740, Germany

Location

Novartis Investigative Site

Salzgitter, 38226, Germany

Location

Novartis Investigative Site

Schkeuditz, 04435, Germany

Location

Novartis Investigative Site

Schorndorf, 73614, Germany

Location

Novartis Investigative Site

Schwäbisch Hall, 74523, Germany

Location

Novartis Investigative Site

Schweinfurt, 97422, Germany

Location

Novartis Investigative Site

Soest, 59494, Germany

Location

Novartis Investigative Site

Stade, 21680, Germany

Location

Novartis Investigative Site

Stendal, 39576, Germany

Location

Novartis Investigative Site

Stolberg, 52222, Germany

Location

Novartis Investigative Site

Stuttgart, 70174, Germany

Location

Novartis Investigative Site

Stuttgart, 70199, Germany

Location

Novartis Investigative Site

Suhl, 98527, Germany

Location

Novartis Investigative Site

Torgau, 04860, Germany

Location

Novartis Investigative Site

Trier, 54290, Germany

Location

Novartis Investigative Site

Tübingen, 72076, Germany

Location

Novartis Investigative Site

Ulm, 89073, Germany

Location

Novartis Investigative Site

Ulm, 89081, Germany

Location

Novartis Investigative Site

Vechta, 49377, Germany

Location

Novartis Investigative Site

Völklingen, 66333, Germany

Location

Novartis Investigative Site

Weiden, 92637, Germany

Location

Novartis Investigative Site

Weinheim, 69469, Germany

Location

Novartis Investigative Site

Wetzlar, 35578, Germany

Location

Novartis Investigative Site

Wiesbaden, 65189, Germany

Location

Novartis Investigative Site

Wilhelmshaven, 26389, Germany

Location

Novartis Investigative Site

Wolfsburg, 38440, Germany

Location

Novartis Investigative Site

Worms, 67550, Germany

Location

Novartis Investigative Site

Würselen, 52146, Germany

Location

Novartis Investigative Site

Würzburg, 97080, Germany

Location

Related Publications (1)

  • Decker T, Brucker C, Engel A, Fasching PA, Gohler T, Jackisch C, Janssen J, Kohler A, Ludtke-Heckenkamp K, Luftner D, Marme F, van Mackelenbergh M, Rautenberg B, Schmidt M, Weide R, Wimberger P, Kisseleff E, Pfister C, Roos C, Wilhelm N, Wockel A. Conditional progression-free survival in patients with metastatic hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer treated with first-line ribociclib and endocrine therapy: real-world data from the RIBANNA study. ESMO Open. 2025 Jun;10(6):105105. doi: 10.1016/j.esmoop.2025.105105. Epub 2025 May 16.

MeSH Terms

Conditions

Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasmsBreast DiseasesSkin DiseasesSkin and Connective Tissue Diseases

Study Officials

  • Novartis Pharmaceuticals

    Novartis Pharmaceuticals

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 29, 2023

First Posted

March 15, 2024

Study Start

October 9, 2017

Primary Completion

March 10, 2025

Study Completion

March 10, 2025

Last Updated

January 27, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will not share

Locations