Key Insights

Highlights

Success Rate

71% trial completion

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 37/100

Termination Rate

10.3%

4 terminated out of 39 trials

Success Rate

71.4%

-15.1% vs benchmark

Late-Stage Pipeline

15%

6 trials in Phase 3/4

Results Transparency

100%

10 of 10 completed with results

Key Signals

10 with results71% success

Data Visualizations

Phase Distribution

26Total
Not Applicable (6)
P 1 (10)
P 2 (4)
P 3 (3)
P 4 (3)

Trial Status

Completed10
Unknown9
Recruiting6
Active Not Recruiting6
Terminated4
Withdrawn2

Trial Success Rate

71.4%

Benchmark: 86.5%

Based on 10 completed trials

Clinical Trials (39)

Showing 20 of 20 trials
NCT06814496Phase 1Recruiting

Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors

NCT04280081Phase 2Active Not Recruiting

A Study of Selpercatinib (LY3527723) in Participants With Advanced Solid Tumors Including RET Fusion-positive Solid Tumors, Medullary Thyroid Cancer and Other Tumors With RET Activation

NCT01298323Phase 3Completed

Study to Determine if Contacting Patients With MTC More Frequently Results in Earlier Detection and Treatment of Signs and Symptoms of AEs and Thus a Decrease in the Percentage of Time Patients Experience AEs During First 12 Months on Vandetanib Treatment

NCT03157128Phase 1Active Not Recruiting

A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)

NCT06141369Not ApplicableRecruiting

Treatment of Advanced Endocrine Tumor With Iindividualized mRNA Neoantigen Vaccine (mRNA-0523-L001)

NCT01660984RecruitingPrimary

Natural History Study of Children and Adults With Medullary Thyroid Cancer

NCT04211337Phase 3Active Not RecruitingPrimary

A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer

NCT03899792Phase 1Active Not RecruitingPrimary

A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors

NCT02856347Not ApplicableCompletedPrimary

Prospective Study Evaluating the Medullary Thyroid Cancer Management's Care Using PET F-DOPA in Patients With a High Level of Postoperative Residual Thyrocalcitonin

NCT01896479Phase 4Active Not RecruitingPrimary

A Study of Two Different Doses of Cabozantinib (XL184) in Progressive, Metastatic Medullary Thyroid Cancer

NCT05534594Not ApplicableCompletedPrimary

Evaluation of the 18F-PSMA Positron Emission Tomography (PET)/CT in Patients With Medullary Thyroid Cancer

NCT03037385Phase 1Completed

Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors

NCT04522570Not ApplicableActive Not Recruiting

Thermal Ablation of Cervical Metastases From Thyroid Carcinoma

NCT03906331Unknown

Expanded Access for the Treatment of Cancers With Rearranged During Transfection (RET) Activation

NCT06292988CompletedPrimary

Predictive Factors for Medullary Thyroid Cancer Aggressiveness

NCT06523582Recruiting

Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients

NCT04161391Phase 1Terminated

Study of TPX-0046, A RET/SRC Inhibitor in Adult Subjects With Advanced Solid Tumors Harboring RET Fusions or Mutations

NCT06277180Not ApplicableRecruitingPrimary

68Ga-TCR-FAPI PET/CT Guided Precision Surgery for MTC

NCT06243965CompletedPrimary

Is Desmoplastic Stromal Reaction Useful to Modulate Lymph Node Dissection in Sporadic Medullary Thyroid Carcinoma?

NCT05675605Phase 1Unknown

A Study of TY-1091 in Patients With Advanced Solid Tumors

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