Ovulation Triggering 2 vs 3 Follicles

NCT06290921 | Completed

• 1 other identifier: 3472
• Study Type: observational
• Target: 405
• Locations: 1 country
• Sites: 1

Brief Summary

Poor responders in in-vitro fertilization (IVF) cycles represent a major challenge for fertility specialists. Although poor responders tend to have sub-optimal fertility treatment outcomes, many of these patients wish to attempt at least one IVF cycle. Traditionally, IVF cycles producing less than 3 to 4 mature follicles (measuring at least 14 mm) have either been cancelled or converted to intra-uterine insemination (IUI) due to the low pregnancy rates associated with these cycles. The minimal number of follicles required to proceed with egg collection is based on clinical experience, having been determined by weighing the probability of implantation and pregnancy versus the risk of not obtaining quality oocytes or reaching embryo transfer when fewer mature follicles are present. This retrospective quality control study aims to compare pregnancy rates in IVF cycles producing 3 follicles measuring 14 mm and more on trigger day, versus 2 or fewer follicles.

Conditions

Infertility

Outcome Measures

Primary Outcomes (1)

• Clinical Pregnancy Rate

  clinical pregnancy is the presence of fetal heartbeat at the viability ultrasound

  6 to 8 weeks after Frozen Embryo Transfer

Interventions

Ovulation triggering OTHER

Ovulation triggering when women only 2 dominant follicles as opposed to the clinic's standard of 3 follicles or more

Eligibility Criteria

• Age: 18 Years - 42 Years
• Gender Eligibility Details: Women able to have an embryo transfered in their uterus
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Data spreadsheet from 2011 to 2017 of patients having undergone an IVF cycle

You may qualify if:

• Stimulated IVF cycle at clinique ovo
• Patients with a maximum of 3 mature follicles (≥14mm) on the day of ovulation trigger

You may not qualify if:

• Cycle cancelation due to no follicles
• History of recurrent implantation failure
• Contraindication of ovulation induction medication

Sponsors & Collaborators

• Clinique Ovo: lead

Study Sites (1)

Clinique Ovo

Montreal, Quebec, H4P 2S4, Canada

Location

MeSH Terms

Conditions

Infertility

Condition Hierarchy (Ancestors)

Genital Diseases; Urogenital Diseases

Study Officials

• Louise Lapensée, MD

  Clinique Ovo

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 26, 2024
• First Posted: March 4, 2024
• Study Start: February 22, 2024
• Primary Completion: April 1, 2024
• Study Completion: June 11, 2024
• Last Updated: March 20, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)