NCT06283966

Brief Summary

This study will evaluate the effect of triple ICS/LAMA/LABA therapy with BGF MDI 320/14.4/9.6 μg on cardiopulmonary outcomes relative to LAMA/LABA therapy with GFF MDI 14.4/9.6 μg in a population with COPD and elevated cardiopulmonary risk.

Trial Health

88
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
5,000

participants targeted

Target at P75+ for phase_3

Timeline
22mo left

Started Feb 2024

Typical duration for phase_3

Geographic Reach
35 countries

895 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress55%
Feb 2024Mar 2028

First Submitted

Initial submission to the registry

February 21, 2024

Completed
Same day until next milestone

Study Start

First participant enrolled

February 21, 2024

Completed
7 days until next milestone

First Posted

Study publicly available on registry

February 28, 2024

Completed
4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 7, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 7, 2028

Last Updated

March 4, 2026

Status Verified

March 1, 2026

Enrollment Period

4 years

First QC Date

February 21, 2024

Last Update Submit

March 3, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Time to first severe cardiac or COPD event

    Evaluate the effect of combination triple therapy (BGF MDI 320/14.4/9.6 μg) compared with dual bronchodilator therapy (GFF MDI 14.4/9.6 μg) on cardiopulmonary outcomes.

    Up to 3 years

Secondary Outcomes (6)

  • Time to first severe COPD exacerbation event

    Up to 3 years

  • Time to first severe cardiac event

    Up to 3 years

  • Time to cardiopulmonary death

    Up to 3 years

  • Moderate/severe COPD exacerbation rate

    Over time, up 3 years

  • Time to Myocardial Infarction (MI) hospitalization or cardiac death

    Up to 3 years

  • +1 more secondary outcomes

Other Outcomes (1)

  • Serious Adverse Events (SAEs) and Adverse Events leading to discontinuation (DAEs), Adverse Events of Special Interest (AESIs) of pneumonia leading to hospitalization or death

    Up to 3 years

Study Arms (2)

BGF arm

EXPERIMENTAL

BGF MDI 320/14.4/9.6 μg BID

Drug: BGF MDI 320/14.4/9.6 μg

GFF arm

EXPERIMENTAL

GFF MDI 14.4/9.6 μg BID

Drug: GFF MDI 14.4/9.6 μg

Interventions

Budesonide, glycopyrronium, and formoterol fumarate pressurized inhalation suspension

BGF arm

Glycopyrronium and formoterol fumarate pressurized inhalation suspension

GFF arm

Eligibility Criteria

Age40 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Male or female participants must be 40 to 80 years of age inclusive, at the time of signing
  • the ICF.
  • Demonstrate acceptable MDI administration technique at Visit 1 (V1) and Visit 2 (V2)
  • A diagnosis of COPD confirmed by a post-bronchodilator FEV1/FVC ratio \< 70%
  • at V1.
  • Current or former smokers with a history of at least 10 pack-years of cigarette smoking;
  • defined as (number of cigarettes per day/20) x number of years smoked. Previous smokers are defined as those who have stopped smoking for at least 6
  • months prior to V1.
  • A baseline peripheral blood eosinophil count of ≥ 100 cells/mm3 assessed at Visit 1 by
  • the central laboratory
  • A CAT score of ≥ 10 at Visit 1.
  • Participant must fulfill at least 1 of the 4 CV disease/risk factor criteria below \[(a), (b),
  • (c), or (d)\]:
  • : Established CV Disease
  • : Combination of CV risk factors:
  • +17 more criteria

You may not qualify if:

  • Active diagnosis of asthma within the past 5 years (previous diagnosis as a child or adolescent are eligible), asthma-COPD overlap, or any other chronic respiratory disease other than COPD such as alpha-1 antitrypsin deficiency, active tuberculosis, lung fibrosis, sarcoidosis, interstitial lung disease, and pulmonary hypertension.
  • End-stage renal disease requiring renal replacement therapy
  • History of heart or lung transplant or actively listed for heart or lung transplant.
  • Implanted left ventricular assist device or implant anticipated in \< 3 months.
  • History of lung cancer and/or treatment for lung cancer within the 5 years prior to Visit 1.
  • Unstable or life-threatening cardiac disease - participants with any of the following at Visit 1 would be excluded:
  • An MI or unstable angina in the last 8 weeks
  • Unstable or life-threatening cardiac arrhythmia requiring intervention in the last 8 weeks.
  • NOTE: Any participant who experiences unstable or life-threatening cardiac disease during the run-in period will be excluded but can be rescreened 8 weeks after the resolution of the event.
  • Pneumonia and/or moderate or severe COPD exacerbation that has not resolved at least 8 weeks prior to Visit 1
  • Any life-threatening condition, including malignancy, with a life expectancy \< 5 years, other than CV disease or COPD, that might prevent the participant from completing the study.
  • Use of maintenance ICS treatment within the past 12 months.
  • Unable to abstain from protocol-defined prohibited medications
  • Participation in another clinical study with a study intervention administered in the last 30 days or 5 half-lives, whichever is longer prior to Visit 1 (any other investigational product that is not identified in protocol is prohibited for use during the duration of the study).
  • Participants with a known hypersensitivity to LAMA, LABA or ICS or any component of the MDI.
  • +4 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (917)

Research Site

Athens, Alabama, 35611, United States

TERMINATED

Research Site

Cullman, Alabama, 35058, United States

RECRUITING

Research Site

Fairhope, Alabama, 36532, United States

TERMINATED

Research Site

Huntsville, Alabama, 35801, United States

TERMINATED

Research Site

Mobile, Alabama, 36608, United States

RECRUITING

Research Site

Sheffield, Alabama, 35660, United States

WITHDRAWN

Research Site

Gilbert, Arizona, 85296, United States

RECRUITING

Research Site

Glendale, Arizona, 85308, United States

WITHDRAWN

Research Site

Mesa, Arizona, 85206, United States

RECRUITING

Research Site

Mesa, Arizona, 85213, United States

RECRUITING

Research Site

Phoenix, Arizona, 85006, United States

TERMINATED

Research Site

Tempe, Arizona, 85281, United States

RECRUITING

Research Site

Tempe, Arizona, 85283, United States

TERMINATED

Research Site

Tucson, Arizona, 85710, United States

RECRUITING

Research Site

Tucson, Arizona, 85715, United States

RECRUITING

Research Site

Apple Valley, California, 92307, United States

WITHDRAWN

Research Site

Canoga Park, California, 91303, United States

SUSPENDED

Research Site

Castroville, California, 95012, United States

RECRUITING

Research Site

Garden Grove, California, 92844, United States

RECRUITING

Research Site

Gardena, California, 90247, United States

TERMINATED

Research Site

Inglewood, California, 90301, United States

RECRUITING

Research Site

La Mesa, California, 91942, United States

RECRUITING

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La Palma, California, 90623, United States

RECRUITING

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Lomita, California, 90717, United States

RECRUITING

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Long Beach, California, 90815, United States

RECRUITING

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Los Alamitos, California, 90720, United States

TERMINATED

Research Site

Newport Beach, California, 92660, United States

RECRUITING

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Newport Beach, California, 92663, United States

RECRUITING

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North Hollywood, California, 91602, United States

TERMINATED

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Pomona, California, 91768, United States

RECRUITING

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Sacramento, California, 95823, United States

RECRUITING

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Sacramento, California, 95831, United States

RECRUITING

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San Bernardino, California, 92408, United States

TERMINATED

Research Site

San Diego, California, 92111, United States

TERMINATED

Research Site

San Dimas, California, 91773, United States

WITHDRAWN

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Santa Ana, California, 92704, United States

WITHDRAWN

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Tarzana, California, 91356, United States

RECRUITING

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Thousand Oaks, California, 91360, United States

RECRUITING

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Van Nuys, California, 91405, United States

WITHDRAWN

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Vista, California, 92081, United States

RECRUITING

Research Site

Westminster, California, 92683, United States

SUSPENDED

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Aurora, Colorado, 80012, United States

RECRUITING

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Denver, Colorado, 80228, United States

RECRUITING

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Englewood, Colorado, 80110, United States

TERMINATED

Research Site

Washington D.C., District of Columbia, 20016, United States

TERMINATED

Research Site

Boynton Beach, Florida, 33435, United States

RECRUITING

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Bradenton, Florida, 34209, United States

RECRUITING

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Cape Coral, Florida, 33990, United States

RECRUITING

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Clearwater, Florida, 33756, United States

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Clearwater, Florida, 33765, United States

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Crystal River, Florida, 34429, United States

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Cutler Bay, Florida, 33189, United States

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Edgewater, Florida, 32132, United States

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Fort Lauderdale, Florida, 33308, United States

RECRUITING

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Fort Myers, Florida, 33912, United States

TERMINATED

Research Site

Hialeah, Florida, 33012, United States

TERMINATED

Research Site

Hialeah, Florida, 33013, United States

TERMINATED

Research Site

Hollywood, Florida, 33024, United States

RECRUITING

Research Site

Homestead, Florida, 33032, United States

RECRUITING

Research Site

Kissimmee, Florida, 34741, United States

WITHDRAWN

Research Site

Kissimmee, Florida, 34746, United States

RECRUITING

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Lake City, Florida, 32055, United States

TERMINATED

Research Site

Lake City, Florida, 32055, United States

RECRUITING

Research Site

Lake Worth, Florida, 33467, United States

RECRUITING

Research Site

Lakeland, Florida, 33805, United States

RECRUITING

Research Site

Lakeland, Florida, 33813, United States

RECRUITING

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Loxahatchee Groves, Florida, 33470, United States

WITHDRAWN

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Miami, Florida, 33155, United States

RECRUITING

Research Site

Miami, Florida, 33175, United States

RECRUITING

Research Site

Miami, Florida, 33175, United States

TERMINATED

Research Site

Miami Lakes, Florida, 33014, United States

RECRUITING

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Naples, Florida, 34102, United States

RECRUITING

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Ocala, Florida, 34470, United States

RECRUITING

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Orlando, Florida, 32807, United States

RECRUITING

Research Site

Orlando, Florida, 32819, United States

RECRUITING

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Orlando, Florida, 32825, United States

RECRUITING

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Ormond Beach, Florida, 32174, United States

RECRUITING

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Pembroke Pines, Florida, 33024, United States

RECRUITING

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Plantation, Florida, 33324, United States

RECRUITING

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St. Petersburg, Florida, 33713, United States

RECRUITING

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Sun City Center, Florida, 33573, United States

TERMINATED

Research Site

Tamarac, Florida, 33321, United States

RECRUITING

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Tampa, Florida, 33606, United States

RECRUITING

Research Site

Tampa, Florida, 33607, United States

RECRUITING

Research Site

Tampa, Florida, 33625, United States

TERMINATED

Research Site

Fayetteville, Georgia, 30214, United States

TERMINATED

Research Site

Peachtree Corners, Georgia, 30092, United States

WITHDRAWN

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Savannah, Georgia, 31406, United States

RECRUITING

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Tucker, Georgia, 30084, United States

RECRUITING

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Boise, Idaho, 83706, United States

TERMINATED

Research Site

Chicago, Illinois, 60607, United States

RECRUITING

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Winfield, Illinois, 60190, United States

RECRUITING

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Valparaiso, Indiana, 46383, United States

RECRUITING

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Sioux City, Iowa, 51106, United States

RECRUITING

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Newton, Kansas, 67114, United States

TERMINATED

Research Site

Wichita, Kansas, 67218, United States

RECRUITING

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Lexington, Kentucky, 40503, United States

RECRUITING

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Paducah, Kentucky, 42001, United States

TERMINATED

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Lafayette, Louisiana, 70508, United States

RECRUITING

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Monroe, Louisiana, 71201, United States

RECRUITING

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Shreveport, Louisiana, 71105, United States

RECRUITING

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Zachary, Louisiana, 70791, United States

RECRUITING

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Glen Burnie, Maryland, 21061, United States

WITHDRAWN

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Oxon Hill, Maryland, 20745, United States

RECRUITING

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Potomac, Maryland, 20854, United States

TERMINATED

Research Site

Boston, Massachusetts, 02115, United States

RECRUITING

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Ann Arbor, Michigan, 48109, United States

RECRUITING

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Flint, Michigan, 48504, United States

RECRUITING

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Southfield, Michigan, 48034, United States

RECRUITING

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Southfield, Michigan, 48075, United States

RECRUITING

Research Site

Gulfport, Mississippi, 39503, United States

RECRUITING

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Olive Branch, Mississippi, 38654, United States

RECRUITING

Research Site

Kansas City, Missouri, 64116, United States

SUSPENDED

Research Site

Liberty, Missouri, 64068, United States

WITHDRAWN

Research Site

St Louis, Missouri, 63104, United States

RECRUITING

Research Site

St Louis, Missouri, 63136, United States

TERMINATED

Research Site

Missoula, Montana, 59808, United States

RECRUITING

Research Site

Fremont, Nebraska, 68025, United States

RECRUITING

Research Site

Grand Island, Nebraska, 68803, United States

RECRUITING

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Lincoln, Nebraska, 68510, United States

WITHDRAWN

Research Site

Omaha, Nebraska, 68134, United States

TERMINATED

Research Site

Las Vegas, Nevada, 89101, United States

RECRUITING

Research Site

Las Vegas, Nevada, 89102, United States

TERMINATED

Research Site

Las Vegas, Nevada, 89119, United States

TERMINATED

Research Site

Las Vegas, Nevada, 89121, United States

RECRUITING

Research Site

Lawrence, New Jersey, 08648, United States

WITHDRAWN

Research Site

Mullica Hill, New Jersey, 08062, United States

RECRUITING

Research Site

Toms River, New Jersey, 08755, United States

RECRUITING

Research Site

Union City, New Jersey, 07087, United States

WITHDRAWN

Research Site

Albuquerque, New Mexico, 87109, United States

WITHDRAWN

Research Site

Albany, New York, 12205, United States

RECRUITING

Research Site

Albany, New York, 12208, United States

WITHDRAWN

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Bronxville, New York, 10708, United States

WITHDRAWN

Research Site

Brooklyn, New York, 11220, United States

TERMINATED

Research Site

Massapequa, New York, 11758, United States

RECRUITING

Research Site

New Windsor, New York, 12553, United States

RECRUITING

Research Site

New York, New York, 10036, United States

RECRUITING

Research Site

New York, New York, 10065, United States

RECRUITING

Research Site

The Bronx, New York, 10455, United States

RECRUITING

Research Site

Vestal, New York, 13850, United States

TERMINATED

Research Site

Fayetteville, North Carolina, 28303, United States

TERMINATED

Research Site

Greensboro, North Carolina, 27405, United States

RECRUITING

Research Site

Greenville, North Carolina, 27834, United States

RECRUITING

Research Site

Huntersville, North Carolina, 28078, United States

RECRUITING

Research Site

Morehead City, North Carolina, 28557, United States

RECRUITING

Research Site

Raleigh, North Carolina, 27612, United States

SUSPENDED

Research Site

Salisbury, North Carolina, 28144, United States

TERMINATED

Research Site

Statesville, North Carolina, 28625, United States

RECRUITING

Research Site

Statesville, North Carolina, 28677, United States

WITHDRAWN

Research Site

Wilmington, North Carolina, 28412, United States

TERMINATED

Research Site

Winston-Salem, North Carolina, 27104, United States

RECRUITING

Research Site

Beavercreek, Ohio, 45431, United States

TERMINATED

Research Site

Blue Ash, Ohio, 45242, United States

RECRUITING

Research Site

Cleveland, Ohio, 44130, United States

TERMINATED

Research Site

Columbus, Ohio, 43215, United States

RECRUITING

Research Site

Columbus, Ohio, 43235, United States

TERMINATED

Research Site

Marion, Ohio, 43302, United States

RECRUITING

Research Site

Toledo, Ohio, 43617, United States

WITHDRAWN

Research Site

Norman, Oklahoma, 73071, United States

RECRUITING

Research Site

Oklahoma City, Oklahoma, 73134, United States

RECRUITING

Research Site

Tulsa, Oklahoma, 74133, United States

RECRUITING

Research Site

Grants Pass, Oregon, 97527, United States

TERMINATED

Research Site

Medford, Oregon, 97504, United States

RECRUITING

Research Site

Roseburg, Oregon, 97471, United States

WITHDRAWN

Research Site

Camp Hill, Pennsylvania, 17011, United States

RECRUITING

Research Site

DuBois, Pennsylvania, 15801, United States

WITHDRAWN

Research Site

Exton, Pennsylvania, 19341, United States

WITHDRAWN

Research Site

Philadelphia, Pennsylvania, 19107, United States

RECRUITING

Research Site

Philadelphia, Pennsylvania, 19140, United States

RECRUITING

Research Site

Anderson, South Carolina, 29621, United States

RECRUITING

Research Site

Charleston, South Carolina, 29414, United States

RECRUITING

Research Site

Charleston, South Carolina, 29414, United States

TERMINATED

Research Site

Columbia, South Carolina, 29201, United States

WITHDRAWN

Research Site

Gaffney, South Carolina, 29340, United States

RECRUITING

Research Site

Spartanburg, South Carolina, 29303, United States

RECRUITING

Research Site

Union, South Carolina, 29379, United States

RECRUITING

Research Site

Pierre, South Dakota, 57501, United States

WITHDRAWN

Research Site

Rapid City, South Dakota, 57701, United States

RECRUITING

Research Site

Sioux Falls, South Dakota, 57104, United States

RECRUITING

Research Site

Chattanooga, Tennessee, 37421, United States

RECRUITING

Research Site

Elizabethton, Tennessee, 37643, United States

TERMINATED

Research Site

Franklin, Tennessee, 37067, United States

RECRUITING

Research Site

Morristown, Tennessee, 37813, United States

TERMINATED

Research Site

Tullahoma, Tennessee, 37388, United States

RECRUITING

Research Site

Abilene, Texas, 79606, United States

RECRUITING

Research Site

Amarillo, Texas, 79106, United States

WITHDRAWN

Research Site

Austin, Texas, 78704, United States

TERMINATED

Research Site

Brownsville, Texas, 78520, United States

RECRUITING

Research Site

Dallas, Texas, 75225, United States

TERMINATED

Research Site

Dallas, Texas, 75235, United States

TERMINATED

Research Site

Dallas, Texas, 75254, United States

RECRUITING

Research Site

El Paso, Texas, 79902, United States

TERMINATED

Research Site

El Paso, Texas, 79902, United States

RECRUITING

Research Site

Forney, Texas, 75126, United States

RECRUITING

Research Site

Georgetown, Texas, 78633, United States

TERMINATED

Research Site

Houston, Texas, 77002, United States

RECRUITING

Research Site

Houston, Texas, 77008, United States

TERMINATED

Research Site

Houston, Texas, 77024, United States

TERMINATED

Research Site

Houston, Texas, 77025, United States

TERMINATED

Research Site

Houston, Texas, 77074, United States

WITHDRAWN

Research Site

Houston, Texas, 77079, United States

RECRUITING

Research Site

Houston, Texas, 77084, United States

TERMINATED

Research Site

Houston, Texas, 77089, United States

RECRUITING

Research Site

Houston, Texas, 77207, United States

TERMINATED

Research Site

Katy, Texas, 77450, United States

WITHDRAWN

Research Site

Katy, Texas, 77493, United States

WITHDRAWN

Research Site

Kerrville, Texas, 78028, United States

TERMINATED

Research Site

Kingwood, Texas, 77339, United States

RECRUITING

Research Site

Lewisville, Texas, 75057, United States

SUSPENDED

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McAllen, Texas, 78504, United States

RECRUITING

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McKinney, Texas, 75069, United States

RECRUITING

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Paris, Texas, 75462, United States

RECRUITING

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Plano, Texas, 75024, United States

TERMINATED

Research Site

Plano, Texas, 75093, United States

RECRUITING

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Victoria, Texas, 77901, United States

TERMINATED

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Waco, Texas, 76708, United States

RECRUITING

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Wichita Falls, Texas, 76308, United States

TERMINATED

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Wylie, Texas, 75098, United States

RECRUITING

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Bountiful, Utah, 84010, United States

WITHDRAWN

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Ogden, Utah, 84405, United States

RECRUITING

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Salt Lake City, Utah, 84107, United States

TERMINATED

Research Site

West Jordan, Utah, 84088, United States

TERMINATED

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West Valley City, Utah, 84120, United States

RECRUITING

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Newport News, Virginia, 23606, United States

TERMINATED

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Norfolk, Virginia, 23504, United States

RECRUITING

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Richmond, Virginia, 23219, United States

RECRUITING

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Richmond, Virginia, 23226, United States

TERMINATED

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Suffolk, Virginia, 23435, United States

RECRUITING

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Spokane, Washington, 99218, United States

RECRUITING

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Morgantown, West Virginia, 26505, United States

TERMINATED

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Cudahy, Wisconsin, 53110, United States

RECRUITING

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Milwaukee, Wisconsin, 53228, United States

RECRUITING

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Milwaukee, Wisconsin, 53295, United States

TERMINATED

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Buenos Aires, 1425, Argentina

RECRUITING

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Buenos Aires, C1012AAR, Argentina

RECRUITING

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Buenos Aires, C1425BEN, Argentina

RECRUITING

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CABA, C1019ABS, Argentina

RECRUITING

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Capital Federal, C1060ABN, Argentina

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Ciudad de Buenos Aires, C1414AIF, Argentina

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Ciudad de Buenos Aires, C1425AGC, Argentina

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Florida, B1602DQD, Argentina

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Mar del Plata, B7600GWV, Argentina

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Mendoza, M5500CCG, Argentina

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Ranelagh, 1886, Argentina

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Rosario, 2000, Argentina

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San Fernando, B1646EBJ, Argentina

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San Juan Bautista, 1888, Argentina

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San Miguel de Tucumán, 4000, Argentina

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San Miguel de Tucumán, T4000CBC, Argentina

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Birtinya, 4575, Australia

RECRUITING

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Chermside, 4032, Australia

COMPLETED

Research Site

Coffs Harbour, 02450, Australia

RECRUITING

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Dubbo, 2830, Australia

RECRUITING

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Nedlands, 6009, Australia

RECRUITING

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Port Macquarie, 2444, Australia

WITHDRAWN

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Spearwood, 6163, Australia

COMPLETED

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St Albans, 3021, Australia

RECRUITING

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Waitara, 2077, Australia

RECRUITING

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Wangaratta, 3677, Australia

WITHDRAWN

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Bad Ischl, 4820, Austria

RECRUITING

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Braunau am Inn, 5280, Austria

RECRUITING

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Feldbach, 8330, Austria

RECRUITING

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Graz, 8036, Austria

RECRUITING

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Vienna, 1090, Austria

WITHDRAWN

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Belo Horizonte, 30110-934, Brazil

WITHDRAWN

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Belo Horizonte, 30150-221, Brazil

RECRUITING

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Belo Horizonte, 30220-140, Brazil

RECRUITING

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Blumenau, 89030-101, Brazil

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Brasília, 70200-730, Brazil

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Brasília, 70390-700, Brazil

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Brasília, 70712-903, Brazil

RECRUITING

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Brasília, 71681-603, Brazil

WITHDRAWN

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Campina Grande do Sul, 83.430-000, Brazil

RECRUITING

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Campinas, 13060-080, Brazil

RECRUITING

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Caxias do Sul, 95070-560, Brazil

WITHDRAWN

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Curitiba, 80030-110, Brazil

RECRUITING

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Curitiba, 80230-130, Brazil

RECRUITING

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Curitiba, 80810-050, Brazil

RECRUITING

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Fortaleza, 60125-000, Brazil

RECRUITING

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Ijuí, 98700-000, Brazil

RECRUITING

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Juiz de Fora, 36033-318, Brazil

RECRUITING

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Mossoró, 59603-020, Brazil

RECRUITING

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Natal, 59020-035, Brazil

RECRUITING

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Niterói, 24020-096, Brazil

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Passo Fundo, 99010-120, Brazil

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Porto Alegre, 90035-903, Brazil

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Porto Alegre, 90035074, Brazil

RECRUITING

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Porto Alegre, 9061-000, Brazil

RECRUITING

Research Site

Porto Alegre, 91350-200, Brazil

RECRUITING

Research Site

Recife, 50740-465, Brazil

RECRUITING

Research Site

Rio de Janeiro, 20551-030, Brazil

RECRUITING

Research Site

Rio de Janeiro, 22281-100, Brazil

WITHDRAWN

Research Site

Salvador, 40170-130, Brazil

RECRUITING

Research Site

Santo André, 09080-110, Brazil

RECRUITING

Research Site

São Bernardo do Campo, 09715090, Brazil

RECRUITING

Research Site

São Bernardo do Campo, 09750-420, Brazil

RECRUITING

Research Site

São José do Rio Preto, 15090-000, Brazil

RECRUITING

Research Site

São Paulo, 04012-180, Brazil

RECRUITING

Research Site

São Paulo, 05403-000, Brazil

RECRUITING

Research Site

Serra, 29160-750, Brazil

RECRUITING

Research Site

Sorocaba, 18040-425, Brazil

RECRUITING

Research Site

Volta Redonda, 27258-000, Brazil

RECRUITING

Research Site

Votuporanga, 15501-405, Brazil

RECRUITING

Research Site

Burgas, 8000, Bulgaria

RECRUITING

Research Site

Dobrich, 9300, Bulgaria

WITHDRAWN

Research Site

Dupnitsa, 2600, Bulgaria

WITHDRAWN

Research Site

Dupnitsa, 2602, Bulgaria

RECRUITING

Research Site

Haskovo, 6300, Bulgaria

RECRUITING

Research Site

Kozloduy, 3320, Bulgaria

WITHDRAWN

Research Site

Montana, 3400, Bulgaria

RECRUITING

Research Site

Panagyurishte, 4500, Bulgaria

RECRUITING

Research Site

Pazardzhik, 4400, Bulgaria

RECRUITING

Research Site

Pernik, 2300, Bulgaria

RECRUITING

Research Site

Pleven, 5800, Bulgaria

RECRUITING

Research Site

Pleven, 5800, Bulgaria

WITHDRAWN

Research Site

Plovdiv, 4002, Bulgaria

RECRUITING

Research Site

Plovdiv, 4003, Bulgaria

RECRUITING

Research Site

Plovdiv, 4004, Bulgaria

WITHDRAWN

Research Site

Plovdiv, 4023, Bulgaria

RECRUITING

Research Site

Rousse, 7000, Bulgaria

RECRUITING

Research Site

Rousse, 7002, Bulgaria

RECRUITING

Research Site

Sandanski, 2800, Bulgaria

RECRUITING

Research Site

Sevlievo, 5403, Bulgaria

WITHDRAWN

Research Site

Sliven, 8800, Bulgaria

WITHDRAWN

Research Site

Sliven, 8800, Bulgaria

RECRUITING

Research Site

Sofia, 1000, Bulgaria

WITHDRAWN

Research Site

Sofia, 1000, Bulgaria

RECRUITING

Research Site

Sofia, 1202, Bulgaria

RECRUITING

Research Site

Sofia, 1618, Bulgaria

RECRUITING

Research Site

Sofia, 1756, Bulgaria

RECRUITING

Research Site

Stara Zagora, 6003, Bulgaria

RECRUITING

Research Site

Varna, 9000, Bulgaria

WITHDRAWN

Research Site

Varna, 9000, Bulgaria

RECRUITING

Research Site

Vidin, 3700, Bulgaria

RECRUITING

Research Site

Vratsa, 3000, Bulgaria

RECRUITING

Research Site

Yambol, 8600, Bulgaria

RECRUITING

Research Site

Calgary, Alberta, T3R 1W7, Canada

RECRUITING

Research Site

Sherwood Park, Alberta, T8L 0N2, Canada

RECRUITING

Research Site

Kelowna, British Columbia, V1Y 1Z9, Canada

RECRUITING

Research Site

Richmond, British Columbia, V6V 2L1, Canada

RECRUITING

Research Site

Winnipeg, Manitoba, R3L 1Z5, Canada

RECRUITING

Research Site

Sydney, Nova Scotia, B1M 0A1, Canada

RECRUITING

Research Site

Ajax, Ontario, L1S 2J5, Canada

RECRUITING

Research Site

Guelph, Ontario, N1H 1B1, Canada

RECRUITING

Research Site

Hamilton, Ontario, L8L 5G4, Canada

RECRUITING

Research Site

Kingston, Ontario, K7L 2V7, Canada

RECRUITING

Research Site

Kingston, Ontario, K7M 4E7, Canada

RECRUITING

Research Site

Thunder Bay, Ontario, P7B 7C7, Canada

RECRUITING

Research Site

Toronto, Ontario, M5T 3A9, Canada

WITHDRAWN

Research Site

Montreal, Quebec, H4A 3J1, Canada

RECRUITING

Research Site

Québec, Quebec, G1G 5X1, Canada

RECRUITING

Research Site

Québec, Quebec, G1V 4G5, Canada

RECRUITING

Research Site

Québec, Quebec, G1W 4R4, Canada

RECRUITING

Research Site

Québec, Quebec, G3K 2P8, Canada

COMPLETED

Research Site

Saint-Charles-Borromée, Quebec, J6E 2B4, Canada

RECRUITING

Research Site

Trois-Rivières, Quebec, G8T 7A1, Canada

RECRUITING

Research Site

Trois-Rivières, Quebec, G9A 4P3, Canada

RECRUITING

Research Site

Saskatoon, Saskatchewan, S7N 0W8, Canada

WITHDRAWN

Research Site

Curicó, 3341643, Chile

RECRUITING

Research Site

Quillota, 2260000, Chile

RECRUITING

Research Site

Santiago, 7500691, Chile

RECRUITING

Research Site

Santiago, 7691236, Chile

RECRUITING

Research Site

Santiago, 7750495, Chile

WITHDRAWN

Research Site

Talca, 3465584, Chile

RECRUITING

Research Site

Temuco, 4810345, Chile

RECRUITING

Research Site

Victoria, 4720097, Chile

RECRUITING

Research Site

Viña del Mar, 2540488, Chile

RECRUITING

Research Site

Vitacura, 7630226, Chile

TERMINATED

Research Site

Anning, 650000, China

RECRUITING

Research Site

Anyang, 455001, China

RECRUITING

Research Site

Baotou, 014040, China

RECRUITING

Research Site

Baotou, 14010, China

RECRUITING

Research Site

Beijing, 101100, China

TERMINATED

Research Site

Beijing, 10730, China

WITHDRAWN

Research Site

Changsha, 410004, China

COMPLETED

Research Site

Changsha, 410005, China

RECRUITING

Research Site

Changsha, 410015, China

RECRUITING

Research Site

Changsha, 430033, China

RECRUITING

Research Site

Changzhi, 46000, China

RECRUITING

Research Site

Chengdu, 610031, China

RECRUITING

Research Site

Chengdu, 610072, China

RECRUITING

Research Site

Chengdu, 610500, China

RECRUITING

Research Site

Chengdu, 611130, China

RECRUITING

Research Site

Chifeng, 024000, China

RECRUITING

Research Site

Chizhou, 247099, China

RECRUITING

Research Site

Chongqing, 400010, China

RECRUITING

Research Site

Chongqing, 401320, China

RECRUITING

Research Site

Chongqing, 408400, China

RECRUITING

Research Site

Daqing, 163000, China

RECRUITING

Research Site

Dazhou, 635000, China

RECRUITING

Research Site

Foshan, 528000, China

RECRUITING

Research Site

Fuzhou, 350001, China

RECRUITING

Research Site

Guangzhou, 510000, China

RECRUITING

Research Site

Guangzhou, 510120, China

RECRUITING

Research Site

Guangzhou, 510145, China

WITHDRAWN

Research Site

Guangzhou, 510163, China

RECRUITING

Research Site

Guangzhou, 510530, China

RECRUITING

Research Site

Haikou, 570311, China

RECRUITING

Research Site

Hangzhou, 310006, China

RECRUITING

Research Site

Hefei, 230000, China

RECRUITING

Research Site

Hefei, 230061, China

RECRUITING

Research Site

Heze, 274099, China

RECRUITING

Research Site

Hohhot, 010010, China

RECRUITING

Research Site

Hohhot, 750306, China

RECRUITING

Research Site

Huizhou, 516001, China

RECRUITING

Research Site

Huizhou, 516002, China

RECRUITING

Research Site

Jiaozuo, 454002, China

WITHDRAWN

Research Site

Jinhua, 321099, China

RECRUITING

Research Site

Jining, 272029, China

RECRUITING

Research Site

Kaifeng, 475000, China

WITHDRAWN

Research Site

Langfang, 065000, China

RECRUITING

Research Site

Lanzhou, 730000, China

RECRUITING

Research Site

Lishui, 323000, China

RECRUITING

Research Site

Liuchow, 545006, China

RECRUITING

Research Site

Nanchang, 330006, China

RECRUITING

Research Site

Nanchang, 330009, China

RECRUITING

Research Site

Nanjing, 210009, China

RECRUITING

Research Site

Nanyang, 473005, China

RECRUITING

Research Site

Pingxiang, 337055, China

RECRUITING

Research Site

Qingdao, 266011, China

RECRUITING

Research Site

Qingyuan, 511518, China

RECRUITING

Research Site

Ruian, 325299, China

RECRUITING

Research Site

Sanya, 572000, China

RECRUITING

Research Site

Shanghai, 200025, China

RECRUITING

Research Site

Shanghai, 200240, China

RECRUITING

Research Site

Shanghai, 200433, China

RECRUITING

Research Site

Shanghai, 201199, China

RECRUITING

Research Site

Shantou, 515041, China

RECRUITING

Research Site

Shaoxing, 312000, China

SUSPENDED

Research Site

Shenyang, 110022, China

RECRUITING

Research Site

Shenyang, 110032, China

RECRUITING

Research Site

Shenzhen, 518001, China

RECRUITING

Research Site

Shenzhen, 518020, China

RECRUITING

Research Site

Shihezi, 832008, China

RECRUITING

Research Site

Shijiazhuang, 50051, China

RECRUITING

Research Site

Siping, 136000, China

RECRUITING

Research Site

Suining Shi, 629000, China

RECRUITING

Research Site

Taicang, 215400, China

RECRUITING

Research Site

Taiyuan, 030001, China

RECRUITING

Research Site

Taiyuan, 030012, China

RECRUITING

Research Site

Taiyuan, 030032, China

RECRUITING

Research Site

Taizhou, 318000, China

RECRUITING

Research Site

Ürümqi, 831118, China

RECRUITING

Research Site

Weifang, 261000, China

RECRUITING

Research Site

Wenzhou, 325027, China

RECRUITING

Research Site

Xi'an, 710006, China

WITHDRAWN

Research Site

Xiamen, 361004, China

RECRUITING

Research Site

Xiangtan, 411100, China

RECRUITING

Research Site

Xianyang, 750004, China

RECRUITING

Research Site

Xingtai, 054899, China

RECRUITING

Research Site

Xinxiang, 453002, China

RECRUITING

Research Site

Xinxiang, 453100, China

RECRUITING

Research Site

Xuzhou, 221000, China

RECRUITING

Research Site

Xuzhou, 221009, China

RECRUITING

Research Site

Yangzhou, 225000, China

RECRUITING

Research Site

Yangzhou, 225001, China

RECRUITING

Research Site

Yinchuan, 750001, China

RECRUITING

Research Site

Yinchuan, 750004, China

WITHDRAWN

Research Site

Zaozhuang, 277102, China

RECRUITING

Research Site

Zhangzhou, 363099, China

RECRUITING

Research Site

Zhengzhou, 450000, China

RECRUITING

Research Site

Zhengzhou, 450006, China

RECRUITING

Research Site

Zhuhai, 519099, China

RECRUITING

Research Site

Zhumadian, 463000, China

RECRUITING

Research Site

Zhuzhou, 412007, China

RECRUITING

Research Site

Zigong, 643000, China

RECRUITING

Research Site

Armenia, 630004, Colombia

WITHDRAWN

Research Site

Barranquilla, 080020, Colombia

WITHDRAWN

Research Site

Bogotá, 111411, Colombia

WITHDRAWN

Research Site

Manizales, 17001, Colombia

WITHDRAWN

Research Site

Medellín, 050025, Colombia

WITHDRAWN

Research Site

Medellín, 050030, Colombia

WITHDRAWN

Research Site

Piedecuesta, 681017, Colombia

WITHDRAWN

Research Site

Rionegro, 054047, Colombia

WITHDRAWN

Research Site

Brandýs nad Labem, 250 01, Czechia

RECRUITING

Research Site

Jindřichův Hradec, 377 01, Czechia

RECRUITING

Research Site

Olomouc, 772 00, Czechia

COMPLETED

Research Site

Olomouc, 772 00, Czechia

RECRUITING

Research Site

Ostrava, 702 00, Czechia

RECRUITING

Research Site

Prague, 110 00, Czechia

RECRUITING

Research Site

Prague, 140 46, Czechia

RECRUITING

Research Site

Rokycany, 337 22, Czechia

RECRUITING

Research Site

Tábor, 390 03, Czechia

RECRUITING

Research Site

Aalborg, 9000, Denmark

RECRUITING

Research Site

Esbjerg, 6700, Denmark

RECRUITING

Research Site

Hvidovre, 2650, Denmark

RECRUITING

Research Site

København NV, 2400, Denmark

RECRUITING

Research Site

Næstved, 4700, Denmark

RECRUITING

Research Site

Vejle, 7100, Denmark

RECRUITING

Research Site

Helsinki, 00180, Finland

RECRUITING

Research Site

Helsinki, 00980, Finland

RECRUITING

Research Site

Kangasala, 36200, Finland

RECRUITING

Research Site

Kuopio, 70100, Finland

RECRUITING

Research Site

Turku, 20100, Finland

WITHDRAWN

Research Site

Aix-en-Provence, 13616, France

RECRUITING

Research Site

Aurillac, 15000, France

RECRUITING

Research Site

Bayonne, 64100, France

WITHDRAWN

Research Site

Bayonne, 64100, France

RECRUITING

Research Site

Biarritz, 64200, France

WITHDRAWN

Research Site

Blois, 41016, France

RECRUITING

Research Site

Brest, 29200, France

RECRUITING

Research Site

Brest, 29609, France

RECRUITING

Research Site

Cannes, 06414, France

RECRUITING

Research Site

Cherbourg, 50102, France

RECRUITING

Research Site

Créteil, 94000, France

RECRUITING

Research Site

La Tronche, 38700, France

RECRUITING

Research Site

Laval, 53015, France

RECRUITING

Research Site

Le Coudray, 28630, France

RECRUITING

Research Site

Lomme, Cedex 59462, France

RECRUITING

Research Site

Lyon, 69317, France

RECRUITING

Research Site

Marseille, 13003, France

RECRUITING

Research Site

Marseille, 13015, France

RECRUITING

Research Site

Mulhouse, 68100, France

WITHDRAWN

Research Site

Paris, 75651, France

WITHDRAWN

Research Site

Paris, 75679, France

RECRUITING

Research Site

Pessac, 33604, France

RECRUITING

Research Site

Pringy, 74374, France

RECRUITING

Research Site

Quint-Fonsegrives, 31130, France

RECRUITING

Research Site

Reims, 51092, France

RECRUITING

Research Site

Roscoff, 29680, France

TERMINATED

Research Site

Strasbourg, 67091, France

RECRUITING

Research Site

Vandœuvre-lès-Nancy, 54511, France

RECRUITING

Research Site

Vannes, 56017, France

RECRUITING

Research Site

Villeurbanne, 69100, France

RECRUITING

Research Site

Ahrensburg, 22926, Germany

RECRUITING

Research Site

Augsburg, 86150, Germany

RECRUITING

Research Site

Bamberg, 96049, Germany

RECRUITING

Research Site

Berlin, 10625, Germany

RECRUITING

Research Site

Berlin, 10629, Germany

RECRUITING

Research Site

Berlin, 10787, Germany

RECRUITING

Research Site

Berlin, 10961, Germany

RECRUITING

Research Site

Berlin, 12157, Germany

RECRUITING

Research Site

Berlin, 12159, Germany

RECRUITING

Research Site

Berlin, 12203, Germany

RECRUITING

Research Site

Berlin, 12627, Germany

RECRUITING

Research Site

Berlin, 13187, Germany

RECRUITING

Research Site

Bonn, 53127, Germany

WITHDRAWN

Research Site

Bremen, 28215, Germany

WITHDRAWN

Research Site

Bremen, 28259, Germany

WITHDRAWN

Research Site

Cottbus, 03050, Germany

RECRUITING

Research Site

Dachau, 85221, Germany

TERMINATED

Research Site

Darmstadt, 64283, Germany

RECRUITING

Research Site

Deggingen, 73326, Germany

WITHDRAWN

Research Site

Dresden, 01069, Germany

TERMINATED

Research Site

Essen, 45127, Germany

RECRUITING

Research Site

Essen, 45355, Germany

TERMINATED

Research Site

Frankfurt, 60596, Germany

RECRUITING

Research Site

Hamburg, 22335, Germany

RECRUITING

Research Site

Hamburg, 22459, Germany

RECRUITING

Research Site

Hanover, 30449, Germany

RECRUITING

Research Site

Hanover, D-30173, Germany

RECRUITING

Research Site

Heidelberg, 69115, Germany

WITHDRAWN

Research Site

Ibbenbueren, 49477, Germany

RECRUITING

Research Site

Karlsruhe, 76137, Germany

TERMINATED

Research Site

Landsberg, 86899, Germany

RECRUITING

Research Site

Leipzig, 04157, Germany

RECRUITING

Research Site

Leipzig, 04177, Germany

RECRUITING

Research Site

Leipzig, 04299, Germany

RECRUITING

Research Site

Lübeck, 23552, Germany

RECRUITING

Research Site

Mainz, 55128, Germany

RECRUITING

Research Site

Marburg, 35037, Germany

RECRUITING

Research Site

Moers, 47441, Germany

RECRUITING

Research Site

München, 80336, Germany

RECRUITING

Research Site

Offenbach, 63065, Germany

RECRUITING

Research Site

Offenbach, 63069, Germany

WITHDRAWN

Research Site

Peine, 31224, Germany

RECRUITING

Research Site

Rheine, 48431, Germany

RECRUITING

Research Site

Riesa, 01587, Germany

RECRUITING

Research Site

Rosenheim, 83022, Germany

RECRUITING

Research Site

Solingen, 42699, Germany

RECRUITING

Research Site

Wallerfing, 94574, Germany

RECRUITING

Research Site

Weißenburg, 91781, Germany

WITHDRAWN

Research Site

Wermsdorf, 04779, Germany

RECRUITING

Research Site

Wiesbaden, 65183, Germany

RECRUITING

Research Site

Wiesbaden, 65189, Germany

RECRUITING

Research Site

Witten, 58452, Germany

RECRUITING

Research Site

Athens, 11521, Greece

RECRUITING

Research Site

Athens, 11527, Greece

RECRUITING

Research Site

Athens, 12462, Greece

RECRUITING

Research Site

Athens, 15125, Greece

RECRUITING

Research Site

Athens, 17562, Greece

RECRUITING

Research Site

Athens, 18547, Greece

WITHDRAWN

Research Site

Ioannina, 45500, Greece

RECRUITING

Research Site

Pátrai, 26500, Greece

RECRUITING

Research Site

Thessaloniki, 57001, Greece

RECRUITING

Research Site

Thessaloniki, 57010, Greece

RECRUITING

Research Site

Balatonfüred, 8230, Hungary

WITHDRAWN

Research Site

Békéscsaba, H-5600, Hungary

RECRUITING

Research Site

Budapest, 1044, Hungary

RECRUITING

Research Site

Budapest, 1121, Hungary

RECRUITING

Research Site

Budapest, 1203, Hungary

WITHDRAWN

Research Site

Debrecen, 4032, Hungary

RECRUITING

Research Site

Edelény, 3780, Hungary

RECRUITING

Research Site

Encs, 3860, Hungary

SUSPENDED

Research Site

Gödöllő, 2100, Hungary

WITHDRAWN

Research Site

Gyöngyös - Mátraháza, 3200, Hungary

RECRUITING

Research Site

Hajdúnánás, 4080, Hungary

RECRUITING

Research Site

Kalocsa, 6300, Hungary

RECRUITING

Research Site

Komádi, 4138, Hungary

RECRUITING

Research Site

Monor, 2200, Hungary

WITHDRAWN

Research Site

Pécs, 7626, Hungary

WITHDRAWN

Research Site

Püspökladány, 4150, Hungary

RECRUITING

Research Site

Százhalombatta, 2440, Hungary

RECRUITING

Research Site

Szeged, 6724, Hungary

RECRUITING

Research Site

Székesfehérvár, 8000, Hungary

WITHDRAWN

Research Site

Szolnok, 5000, Hungary

RECRUITING

Research Site

Tapolca, 8300, Hungary

RECRUITING

Research Site

Törökbálint, 2045, Hungary

RECRUITING

Research Site

Vajszló, 7838, Hungary

RECRUITING

Research Site

Ahmedabad, 380015, India

RECRUITING

Research Site

Ahmedabad, 382421, India

RECRUITING

Research Site

Aligarh, 202002, India

RECRUITING

Research Site

Belagavi, 590010, India

RECRUITING

Research Site

Calicut, 673 008, India

RECRUITING

Research Site

Chandigarh, 160012, India

WITHDRAWN

Research Site

Dehradun, 248001, India

RECRUITING

Research Site

Delhi, 110029, India

RECRUITING

Research Site

Dwārka, 110075, India

RECRUITING

Research Site

Hyderabad, 500035, India

RECRUITING

Research Site

Hyderabad, 500068, India

RECRUITING

Research Site

Jaipur, 302017, India

RECRUITING

Research Site

Kolkata, 700014, India

WITHDRAWN

Research Site

Kolkata, 700073, India

RECRUITING

Research Site

Mangalore, 575003, India

WITHDRAWN

Research Site

Mumbai, 400008, India

WITHDRAWN

Research Site

Nagpur, 441108, India

RECRUITING

Research Site

New Delhi, 110005, India

WITHDRAWN

Research Site

New Delhi, 110029, India

WITHDRAWN

Research Site

Pune, 411062, India

RECRUITING

Research Site

Vijayawada, 520 008, India

RECRUITING

Research Site

Ancona, 60100, Italy

RECRUITING

Research Site

Florence, 50134, Italy

RECRUITING

Research Site

Genoa, 16132, Italy

RECRUITING

Research Site

Mestre, 30174, Italy

RECRUITING

Research Site

Milan, 20123, Italy

COMPLETED

Research Site

Naples, 80131, Italy

RECRUITING

Research Site

Pavia, 27100, Italy

RECRUITING

Research Site

Perugia, 06126, Italy

RECRUITING

Research Site

Roma, 00128, Italy

RECRUITING

Research Site

Roma, 00133, Italy

RECRUITING

Research Site

Roma, 161, Italy

RECRUITING

Research Site

Rome, 00189, Italy

RECRUITING

Research Site

Siena, 53100, Italy

RECRUITING

Research Site

Varese, 21100, Italy

RECRUITING

Research Site

Chūōku, 103-0027, Japan

RECRUITING

Research Site

Fujieda-shi, 426-8677, Japan

RECRUITING

Research Site

Fukuoka, 814-0180, Japan

RECRUITING

Research Site

Kitakyushu, 802-0052, Japan

RECRUITING

Research Site

Kobe, 651-0072, Japan

RECRUITING

Research Site

Kure-shi, 737-0193, Japan

RECRUITING

Research Site

Kure-shi, 737-8505, Japan

RECRUITING

Research Site

Kyoto, 607-8062, Japan

RECRUITING

Research Site

Minoh, 562-0003, Japan

RECRUITING

Research Site

Mizunami-shi, 509-6134, Japan

RECRUITING

Research Site

Okayama, 702-8055, Japan

RECRUITING

Research Site

Osaka, 530-0012, Japan

RECRUITING

Research Site

Osaka, 545-8586, Japan

RECRUITING

Research Site

Osaki-shi, 989-6183, Japan

RECRUITING

Research Site

Sendai, 980-8574, Japan

RECRUITING

Research Site

Shinjuku-ku, 160-8582, Japan

RECRUITING

Research Site

Shinjuku-ku, 162-8655, Japan

RECRUITING

Research Site

Takamatsu, 761-8073, Japan

RECRUITING

Research Site

Yamagata, 990-8533, Japan

RECRUITING

Research Site

Yanagawa-shi, 832-0059, Japan

RECRUITING

Research Site

Yokohama, 234-0054, Japan

RECRUITING

Research Site

Alor Star, 05460, Malaysia

RECRUITING

Research Site

Kajang, 43000, Malaysia

RECRUITING

Research Site

Kuala Lumpur, 50586, Malaysia

RECRUITING

Research Site

Kuala Pilah, 72000, Malaysia

RECRUITING

Research Site

Sandakan, 90000, Malaysia

RECRUITING

Research Site

Sarawak Miri, 98000, Malaysia

RECRUITING

Research Site

Seremban, 70300, Malaysia

WITHDRAWN

Research Site

Sibu, 96000, Malaysia

RECRUITING

Research Site

Benito Juárez, 03650, Mexico

RECRUITING

Research Site

Chihuahua City, 31000, Mexico

RECRUITING

Research Site

Cuernavaca, 62290, Mexico

WITHDRAWN

Research Site

Cuernavaca, 62290, Mexico

RECRUITING

Research Site

Culiacán, 80020, Mexico

RECRUITING

Research Site

Guadalajara, 44200, Mexico

RECRUITING

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Guadalajara, 44670, Mexico

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Juriquilla, 76320, Mexico

RECRUITING

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Metepec, 52170, Mexico

RECRUITING

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Mexico City, 03310, Mexico

WITHDRAWN

Research Site

Mérida, 97130, Mexico

RECRUITING

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Monterrey, 64310, Mexico

RECRUITING

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Monterrey, 64460, Mexico

RECRUITING

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Oaxaca City, 68020, Mexico

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Tijuana, 22010, Mexico

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Veracruz, 91910, Mexico

RECRUITING

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Xalapa, 91193, Mexico

RECRUITING

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Zapopan, 45138, Mexico

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Kongsberg, 3612, Norway

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Lørenskog, 1478, Norway

RECRUITING

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Skedsmokorset, N-2020, Norway

RECRUITING

Research Site

Trondheim, 7030, Norway

RECRUITING

Research Site

El Agustino, LIMA 10, Peru

WITHDRAWN

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Lima, 15023, Peru

RECRUITING

Research Site

Lima, 15023, Peru

WITHDRAWN

Research Site

Lima, 15024, Peru

RECRUITING

Research Site

Lima, 15036, Peru

WITHDRAWN

Research Site

Lima, 15036, Peru

RECRUITING

Research Site

Lima, 15038, Peru

NOT YET RECRUITING

Research Site

Lima, 15046, Peru

RECRUITING

Research Site

Lima, 15088, Peru

RECRUITING

Research Site

Lima, 15102, Peru

RECRUITING

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Lima, 15131, Peru

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Lima, 15324, Peru

RECRUITING

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Lima, 33, Peru

RECRUITING

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Lima, L18, Peru

RECRUITING

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Lima, LIMA 01, Peru

NOT YET RECRUITING

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Lima, LIMA 1, Peru

RECRUITING

Research Site

Lima, LIMA 21, Peru

RECRUITING

Research Site

Piura, 20001, Peru

RECRUITING

Research Site

Dagupan, 2400, Philippines

RECRUITING

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Iloilo City, 5000, Philippines

RECRUITING

Research Site

Las Piñas, 1742, Philippines

RECRUITING

Research Site

Mabalacat, 2023, Philippines

WITHDRAWN

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Manadaluyong City, 1552, Philippines

WITHDRAWN

Research Site

Manila, 1000, Philippines

WITHDRAWN

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Manila, 1000, Philippines

RECRUITING

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Marilao, 3019, Philippines

RECRUITING

Research Site

Puerto Princesa City, 5300, Philippines

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Quezon City, 0870, Philippines

RECRUITING

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Quezon City, 1100, Philippines

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Quezon City, 1109, Philippines

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Roxas City, 5800, Philippines

WITHDRAWN

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Tondo, 1012, Philippines

RECRUITING

Research Site

Bialystok, 15-044, Poland

RECRUITING

Research Site

Bialystok, 15-879, Poland

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Bydgoszcz, 85-796, Poland

RECRUITING

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Chęciny, 26-060, Poland

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Chojnice, 89-600, Poland

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Częstochowa, 42-217, Poland

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Inowrocław, 88-100, Poland

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Karczew, 05-480, Poland

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Katowice, 40-081, Poland

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Katowice, 40-648, Poland

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Kielce, 25-426, Poland

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Kielce, 25-751, Poland

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Krakow, 31-501, Poland

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Krakow, 31-513, Poland

RECRUITING

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Libiąż, 32-590, Poland

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Lodz, 91-363, Poland

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Lodz, 92-003, Poland

WITHDRAWN

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Lubin, 59-300, Poland

WITHDRAWN

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Lublin, 20-011, Poland

RECRUITING

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Lublin, 20-601, Poland

RECRUITING

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Ostrowiec Świętokrzyski, 27-400, Poland

WITHDRAWN

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Piaseczno, 05-500, Poland

RECRUITING

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Poznan, 60-192, Poland

RECRUITING

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Poznan, 61-578, Poland

SUSPENDED

Research Site

Płock, 09-407, Poland

RECRUITING

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Rzeszów, 35-205, Poland

RECRUITING

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Sieradz, 98-200, Poland

SUSPENDED

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Skórzewo, 60-185, Poland

RECRUITING

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Sochaczew, 96-500, Poland

RECRUITING

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Sosnowiec, 41-200, Poland

WITHDRAWN

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Sosnowiec, 41-208, Poland

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Szczecin, 70-111, Poland

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Słupsk, 76-200, Poland

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Torun, 87-100, Poland

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Ustroń, 43-450, Poland

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Warsaw, 00-215, Poland

RECRUITING

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Warsaw, 00-719, Poland

RECRUITING

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Warsaw, 04-501, Poland

TERMINATED

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Wroclaw, 53-673, Poland

RECRUITING

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Wroclaw, 54-239, Poland

RECRUITING

Research Site

Bucharest, 011461, Romania

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Bucharest, 012363, Romania

RECRUITING

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Bucharest, 050159, Romania

RECRUITING

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Cluj-Napoca, 400371, Romania

RECRUITING

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Leamna de Sus, 207129, Romania

RECRUITING

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Negreşti-Oaş, 445200, Romania

RECRUITING

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Oradea, 410176, Romania

RECRUITING

Research Site

Târgu Mureş, 540098, Romania

RECRUITING

Research Site

Timișoara, 300203, Romania

RECRUITING

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Timișoara, 300310, Romania

RECRUITING

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Timișoara, 300336, Romania

RECRUITING

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Belgrade, 11000, Serbia

RECRUITING

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Belgrade, 11040, Serbia

RECRUITING

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Belgrade, 11080, Serbia

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Kamenitz, 21204, Serbia

RECRUITING

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Kragujevac, 34000, Serbia

RECRUITING

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Niš, 18108, Serbia

RECRUITING

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Novi Sad, 21000, Serbia

RECRUITING

Research Site

Bratislava, 949 01, Slovakia

RECRUITING

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Brezno, 977 01, Slovakia

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Humenné, 066 01, Slovakia

RECRUITING

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Košice, 04022, Slovakia

RECRUITING

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Kráľovský Chlmec, 077 01, Slovakia

WITHDRAWN

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Levice, 93401, Slovakia

RECRUITING

Research Site

Prešov, 081 81, Slovakia

WITHDRAWN

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Topoľčany, 955 01, Slovakia

RECRUITING

Research Site

Anyang-si, 14068, South Korea

RECRUITING

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Busan, 49201, South Korea

RECRUITING

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Daegu, 42415, South Korea

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Gwangju, 61469, South Korea

WITHDRAWN

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Jeonju, 54907, South Korea

RECRUITING

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Seoul, 03312, South Korea

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Seoul, 04763, South Korea

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Seoul, 06591, South Korea

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Seoul, 07061, South Korea

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Seoul, 08308, South Korea

RECRUITING

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Seoul, 143-729, South Korea

RECRUITING

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Uijeongbu-si, 11765, South Korea

RECRUITING

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Ulsan, 44033, South Korea

RECRUITING

Research Site

Alicante, 03010, Spain

RECRUITING

Research Site

Badia Del Vallès, 08214, Spain

RECRUITING

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Barakaldo, 48903, Spain

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Barcelona, 08017, Spain

RECRUITING

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Barcelona, 08840, Spain

RECRUITING

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Castro Urdiales, 39700, Spain

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Córdoba, 14940, Spain

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Granada, 18014, Spain

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Madrid, 28031, Spain

RECRUITING

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Marbella (Málaga), 29603, Spain

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Mataró, 08302, Spain

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Mataró, 08303, Spain

RECRUITING

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Málaga, 29010, Spain

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Palma, 07011, Spain

RECRUITING

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Patraix, 46017, Spain

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Santa Cruz de Tenerife, 38010, Spain

WITHDRAWN

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Santiago de Compostela-Coruña, 15706, Spain

RECRUITING

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Danderyd, 182 88, Sweden

RECRUITING

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Gothenburg, 413 46, Sweden

WITHDRAWN

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Gothenburg, 41345, Sweden

RECRUITING

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Höllviken, 236 51, Sweden

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Kungsbacka, 43480, Sweden

RECRUITING

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Lund, 22242, Sweden

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Örebro, 70185, Sweden

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Stockholm, 117 27, Sweden

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Stockholm, 11883, Sweden

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Stockholm, 171 76, Sweden

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Umeå, 901 85, Sweden

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Uppsala, 752 33, Sweden

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Changhua County, 500, Taiwan

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Kaohsiung City, 82445, Taiwan

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Kaohsiung City, TAIWAN, Taiwan

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Taichung, 40201, Taiwan

RECRUITING

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Taichung, 404, Taiwan

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Taichung, 40705, Taiwan

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Taichung, 433004, Taiwan

RECRUITING

Research Site

Tainan, 70403, Taiwan

RECRUITING

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Taipei, 10002, Taiwan

RECRUITING

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Taipei, 10449, Taiwan

TERMINATED

Research Site

Taoyuan, 330, Taiwan

RECRUITING

Research Site

Taoyuan District, 00333, Taiwan

RECRUITING

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Yunlin, 640, Taiwan

RECRUITING

Research Site

Bang Kra So, 11000, Thailand

RECRUITING

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Bangkok, 10700, Thailand

RECRUITING

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Hat Yai, 90110, Thailand

RECRUITING

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Khlong Luang, 12120, Thailand

RECRUITING

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Muang, 22000, Thailand

RECRUITING

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Muang, 40002, Thailand

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Muang, 50200, Thailand

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Ongkharak, 26120, Thailand

RECRUITING

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Phitsanulok, 65000, Thailand

RECRUITING

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Ratchathewi, 10400, Thailand

RECRUITING

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Adana, 01060, Turkey (Türkiye)

RECRUITING

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Adana, 01330, Turkey (Türkiye)

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Afyonkarahisar, 03030, Turkey (Türkiye)

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Antalya, 07059, Turkey (Türkiye)

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Bursa, 16059, Turkey (Türkiye)

RECRUITING

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Bursa, 16110, Turkey (Türkiye)

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Çanakkale, 17110, Turkey (Türkiye)

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Çankaya, 06700, Turkey (Türkiye)

RECRUITING

Research Site

Isparta, 32260, Turkey (Türkiye)

WITHDRAWN

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Istanbul, 34785, Turkey (Türkiye)

NOT YET RECRUITING

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Istanbul, 34844, Turkey (Türkiye)

RECRUITING

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Izmir, 35330, Turkey (Türkiye)

RECRUITING

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Izmir, 35965, Turkey (Türkiye)

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Kayseri, 38030, Turkey (Türkiye)

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Kocaeli, 41380, Turkey (Türkiye)

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Mersin, 33343, Turkey (Türkiye)

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Tekirdağ, 59030, Turkey (Türkiye)

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Zeytinburnu, 34020, Turkey (Türkiye)

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Chernivtsi, 58029, Ukraine

RECRUITING

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Chernivtsі, 58002, Ukraine

RECRUITING

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Ivano-Frankivsk, 76018, Ukraine

RECRUITING

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Ivano-Frankivsk, 76019, Ukraine

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Kyiv, 02002, Ukraine

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Kyiv, 02081, Ukraine

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Kyiv, 03037, Ukraine

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Kyiv, 03680, Ukraine

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Lviv, 79016, Ukraine

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Ternopil, 46001, Ukraine

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Uzhhorod, 88002, Ukraine

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Uzhhorod, 88018, Ukraine

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Vinnytsia, 21001, Ukraine

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Vinnytsia, 21009, Ukraine

WITHDRAWN

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Vinnytsia, 21029, Ukraine

RECRUITING

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Bicester, OX26 6AT, United Kingdom

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Bollington, SK10 5JH, United Kingdom

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Bradford, BD13 2GD, United Kingdom

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Cardiff, CF37 2DR, United Kingdom

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Chesterfield, S40 4AA, United Kingdom

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Corby, NN17 2UR, United Kingdom

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Cottingham, HU16 5JQ, United Kingdom

WITHDRAWN

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Fowey, PL23 1DT, United Kingdom

RECRUITING

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Glasgow, G4 0SF, United Kingdom

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Hounslow, TW4 7NR, United Kingdom

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Liverpool, L14 3PE, United Kingdom

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London, EC1M 6BQ, United Kingdom

COMPLETED

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London, NW3 2QG, United Kingdom

RECRUITING

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London, SW1P 2PF, United Kingdom

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Manchester, M8 5RB, United Kingdom

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Newquay, TR7 1RU, United Kingdom

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North Somerset, BS23 3HQ, United Kingdom

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Northallerton, DL7 8AW, United Kingdom

RECRUITING

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Norwich, NR1 1RB, United Kingdom

WITHDRAWN

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Nottingham, NG9 6DX, United Kingdom

WITHDRAWN

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Perth, PH1 1NX, United Kingdom

WITHDRAWN

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Poole, BH16 5PW, United Kingdom

RECRUITING

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Sheffield, S7 1NF, United Kingdom

RECRUITING

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Torbay, TQ1 4QX, United Kingdom

RECRUITING

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Whitney, OX29 4QB, United Kingdom

RECRUITING

Research Site

Witney, OX28 6JS, United Kingdom

RECRUITING

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, ObstructiveLung DiseasesRespiratory Tract DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Central Study Contacts

AstraZeneca Clinical Study Information Center

CONTACT

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: This is a Phase III randomized, double-blind, parallel group, multi-center event-driven study comparing BGF MDI 320/14.4/9.6 μg BID with GFF MDI 14.4/9.6 μg BID in participants with COPD who are at risk of a cardiopulmonary event.
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 21, 2024

First Posted

February 28, 2024

Study Start

February 21, 2024

Primary Completion (Estimated)

March 7, 2028

Study Completion (Estimated)

March 7, 2028

Last Updated

March 4, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will share

Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal. All request will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure. Yes, indicates that AZ are accepting requests for IPD, but this does not mean all requests will be shared.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA Pharma Data Sharing Principles. For details of our timelines, please rerefer to our disclosure commitment at: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.
Access Criteria
When a request has been approved AstraZeneca will provide access to the deidentified individual patient-level data in an approved sponsored tool . Signed Data Sharing Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information. Additionally, all users will need to accept the terms and conditions of the SAS MSE to gain access. For additional details, please review the Disclosure Statements at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.
More information

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