Evaluation of the Effects of Mefenamic Acid and Dexketoprofen on Postoperative Wisdom Dental Surgery

NCT06280014 | Completed

• 1 other identifier: YYU-09/15.12.2021
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study was administered to 22 female and 8 male patients. Patients with impacted wisdom teeth on both sides of the mandible were selected. After impacted tooth extraction, the patient used mefenamic acid on one side and dexketoprofen on the other side for postoperative pain relief. The effects of these two materials on patient comfort were investigated.

Conditions

Tooth, Impacted; Tooth Diseases

Keywords

impacted wisdom teeth; dexketoprofen; mefenamic acid

Outcome Measures

Primary Outcomes (3)

• Mouth opening measurements

  The distance between the incisals of the patient's central teeth at maximal mouth opening.

  0-28 days

• Facial edema

  Measurement between facial craniometric points (angulus-tragus, angulus-lateral canthus, angulus-nasal base, angulus-lateral canthus, and angulus-pogonion). The number of participants in the split mouth model was 22. A total of 44 impacted teeth were extracted and edema was measured before and 1 week after each extraction.

  0-28 days

• Visual Analog Scale

  A numerical rating scale VAS was used for pain analysis (0=no pain, 10=most severe pain). The pain levels at 24 hours, 48 hours and 1 week after the surgical procedure were recorded on the patient follow-up form by all patients who participated in the study by explaining that there was no pain at the "zero" level and the most severe pain known at the "10" level on the pain scale, which was organized as a 10 cm horizontal line on the prepared forms.

  0-28 days

Study Arms (2)

Mefenamic acid was used to see post operative effects after extraction of 3rd molar in study group

EXPERIMENTAL

In this study of 30 patients, 22 females and 8 males, 60 fully impacted lower wisdom teeth were extracted bilaterally and in the same position. One of the bilaretal teeth of the patients was randomly selected and mefenamic acid was used as a drug to see post operative effects after extraction of impacted 3rd molars in the study group.

Procedure: Surgery of impacted mandibular wisdom teeth

Dexketoprofen was used to see post operative effects after extraction of 3rd molar in control group

PLACEBO COMPARATOR

Bilateral impacted wisdom teeth of the patients were randomly selected. After the tooth in the experimental group was extracted, the other impacted wisdom tooth was selected as the control group and dexketoprofen was used as a drug to see post operative effects.

Procedure: Surgery of impacted mandibular wisdom teeth

Interventions

Surgery of impacted mandibular wisdom teeth PROCEDURE

All surgical procedures were performed by the same surgeon using the standard surgical technique described below. The anesthetic used was 4% articaine with 1:100,000 adrenaline. In all patients, a sulcus incision was made in the lower second molar and an envelope incision in the third molar region, the mucoperiosteal flap was removed, and extraction was performed with a bone elevator and a third molar elevator. If necessary, the impacted molar was incised with a high-speed dental handpiece and a fissure bur. The wound was irrigated with copious amounts of saline, and the wound edges were carefully sutured with simple 4.0 silk braided non-absorbable sutures. After extraction of impacted wisdom tooth, the patient was given mefenamic acid as a medication.

Also known as: Surgery of impacted molar teeth

Mefenamic acid was used to see post operative effects after extraction of 3rd molar in study group

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Volunteers with bilateral fully impacted mandibular wisdom teeth

You may not qualify if:

• Patients were excluded from the study if they did not understand the clinical procedures of the study,
• Had allergies or intolerance to any of the substances used in the study,
• Patients on anticoagulant or psychiatric treatment,
• Pregnant or breastfeeding,
• Patients using oral contraceptiveswere,
• Diabetic,
• Patients with periodontal disease or active infection,
• Poor oral hygiene

Sponsors & Collaborators

• Yuzuncu Yil University: lead

Study Sites (1)

Serap Keskin Tunc

Van, 65100, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Tooth, Impacted; Tooth Diseases

Condition Hierarchy (Ancestors)

Stomatognathic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor Serap Keskin Tunc

Study Record Dates

• First Submitted: February 19, 2024
• First Posted: February 28, 2024
• Study Start: January 20, 2022
• Primary Completion: February 20, 2022
• Study Completion: September 25, 2023
• Last Updated: February 28, 2024

Record last verified: 2024-02

Locations

TU (1)