The Diagnostic Value of End-Tidal CO2 in Patients Diagnosed With Pneumothorax

NCT06276751 | Completed

• 1 other identifier: E1-23-3870 ptx endtidalco2
• Study Type: observational
• Target: 43
• Locations: 1 country
• Sites: 1

Brief Summary

Pneumothorax (PTX) is defined as the accumulation of air in the pleural space. PTX can cause a disruption in the perfusion of lung tissue in the affected area and increase intrathoracic pressure, potentially leading to obstruction of venous return and, consequently, posing a life-threatening condition. Therefore, PTX requiring urgent intervention is a significant concern in emergency departments. End-tidal carbon dioxide (ETCO2) provides insight into carbon dioxide levels resulting from lung perfusion and serves as a respiratory parameter informing the prognosis of various critical illnesses. One of the most important factors determining lung perfusion is the effective lung area. Among the crucial issues for emergency departments are PTX cases, which typically regress following urgent intervention, leading to the establishment of an effective lung area. Hypotheses have been proposed in the literature suggesting that ETCO2 may be affected in PTX cases due to the relationship between effective lung area and ETCO2. In this study, investigetors aimed to investigate changes in ETCO2 levels following tube thoracostomy applied to PTX cases.

Conditions

Pneumothorax

Outcome Measures

Primary Outcomes (5)

• ETCO2-0

  It was defined as the end-tidal CO2 (ETCO2) measured at the emergency department visit.

  Five minutes have passed since the emergency room application.

• ΔETCO2-1

  The change in ETCO2-1 compared to ETCO2-0.

  Two hours after the emergency room application.

• ΔETCO2-2

  The change in ETCO2-2 compared to ETCO2-0.

  Four hours after the emergency room application.

• ETCO2-1

  End-tidal CO2 measured 2 hours after emergency department admission.

  Two hours after the emergency room application.

• ETCO2-2

  End-tidal CO2 measured 2 hours after emergency department admission.

  Four hours after the emergency room application.

Interventions

End-tidal CO2 monitor PROCEDURE

Throughout the study, measurements were taken at 2 and 4 hours after tube thoracostomy was applied to every patient undergoing the procedure.

Also known as: Measurement of end-tidal CO2 after tube thoracostomy application.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study included patients aged 18 and over, without any comorbidities, diagnosed with spontaneous or traumatic pneumothorax, who underwent tube thoracostomy, and had no other organ damage or injury.

You may qualify if:

• Patients aged 18 and over
• Individuals without comorbidities
• Those diagnosed with spontaneous or traumatic pneumothorax
• Patients who underwent tube thoracostomy
• Individuals without other organ damage or injury

You may not qualify if:

• Patients under 18 years of age or over 65 years of age
• Patients who refuse to participate in the study
• Pregnant women
• Individuals diagnosed with acute/chronic lung disease
• Those with a history of advanced heart failure
• Individuals with advanced systemic disease
• Patients with a history of malignancy (cancer)
• Individuals with chronic liver disease
• Those using sedative and analgesic neuro-psychiatric drugs
• Patients with a history of psychological or neurological disorders
• Individuals with acute organ damage or failure

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara Bilkent Şehir Hastanesi

Ankara, Çankaya, 06170, Turkey (Türkiye)

Location

Related Publications (1)

• Lee GM, Kim YW, Lee S, Do HH, Seo JS, Lee JH. End-Tidal Carbon Dioxide Monitoring for Spontaneous Pneumothorax. Emerg Med Int. 2021 Jun 14;2021:9976543. doi: 10.1155/2021/9976543. eCollection 2021.

  PMID: 34234966 BACKGROUND

MeSH Terms

Conditions

Pneumothorax

Condition Hierarchy (Ancestors)

Pleural Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D.

Study Record Dates

• First Submitted: February 15, 2024
• First Posted: February 26, 2024
• Study Start: August 15, 2023
• Primary Completion: February 6, 2024
• Study Completion: February 13, 2024
• Last Updated: February 26, 2024

Record last verified: 2024-02

Locations

TU (1)