Protein Molecular Characteristics and Prognosis of Cervical Neuroendocrine Tumors

NCT06276309 | Recruiting

• 1 other identifier: NECC2401
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 9

Brief Summary

The clinical diagnosis and treatment data of 300 cases of cervical neuroendocrine tumors were collected, including age, preoperative biopsy pathology results, postoperative histopathological results, TCT results, and colposcopy biopsy pathology results. At the same time, paraffin tissue specimens (remaining specimens after pathological diagnosis) from 100 cases of cervical neuroendocrine tumors from multiple centers across the country were collected to establish a cervical neuroendocrine tumor data follow-up database. Protein concentration and omics analysis were performed on the data results, to evaluate the molecular characteristics and prognosis of cervical neuroendocrine tumor proteins, and to preliminarily explore its clinical application value.

Conditions

Neuroendocrine Neoplasm; China; Women; Cervical Cancer; Cervical Lesion

Outcome Measures

Primary Outcomes (2)

• mortality rate

  3-year mortality rate for cervical neuroendocrine carcinoma

  Among patients with cervical neuroendocrine carcinoma, the mortality rate within 3 years following surgery

• Disease-free survival

  3-year disease-free survival for cervical neuroendocrine carcinoma

  Among patients with cervical neuroendocrine carcinoma, the disease-free survival within 3 years following surgery

Eligibility Criteria

• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All 300 patients were diagnosed with cervical neuroendocrine carcinoma by histopathology

You may qualify if:

• Patients diagnosed with cervical neuroendocrine carcinoma by histopathology
• Clinical data were complete

You may not qualify if:

• Patients who are not being treated in our hospital
• Patients with lack of follow-up data, unable to obtain survival information
• Patients call to refuse to participate in this project
• The quality of paraffin specimens can not meet the requirements of proteome concentration determination

Sponsors & Collaborators

• Fujian Maternity and Child Health Hospital: lead

Study Sites (9)

Fujian Maternity and Child Health Hospital

Fuzhou, Fujian, 350001, China

RECRUITING

Fujian Provincial Hospital

Fuzhou, Fujian, China

RECRUITING

Ningde Mindong Hospital

Ningde, Fujian, China

RECRUITING

Putian City first Hospital

Putian, Fujian, China

RECRUITING

The Second Affiliated Hospital of Fujian Medical University

Quanzhou, Fujian, China

RECRUITING

Zhangzhou affiliated Hospital of Fujian Medical University

Zhangzhou, Fujian, 363000, China

RECRUITING

Maternal and Child Health Hospital of Hubei Province

Wuhan, Hubei, China

RECRUITING

Xiangya Hospital, Central South University

Changsha, Hunan, China

RECRUITING

Jiangxi maternal and Child Health Hospital

Nanchang, Jiangxi, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Paraffin samples collected from 100 cases of cervical neuroendocrine tumors were identified, processed and segmtioned, and protein concentration and proteome were determined to establish the molecular characteristics and prognostic targets of cervical neuroendocrine tumors.

MeSH Terms

Conditions

Neuroendocrine Tumors; Uterine Cervical Neoplasms

Condition Hierarchy (Ancestors)

Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Nerve Tissue; Uterine Neoplasms; Genital Neoplasms, Female; Urogenital Neoplasms; Neoplasms by Site; Uterine Cervical Diseases; Uterine Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases

Study Officials

• Pengming Sun, PhD

  Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University

  STUDY CHAIR

Central Study Contacts

Binhua Dong

CONTACT

+86-0591-87558732; dongbinhua86@fjmu.edu.cn

Pengming Sun

CONTACT

fmsun1975@fjmu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 7, 2024
• First Posted: February 23, 2024
• Study Start: February 1, 2024
• Primary Completion: December 30, 2024
• Study Completion: February 28, 2025
• Last Updated: September 19, 2024

Record last verified: 2024-09

Locations

CN (9)