Mix of Demineralized Freeze-Dried Bone Allograft and Deproteinized Bovine Bone Mineral: a Possible Solution for Alveolar Ridge Preservation?

NCT06275789 | Recruiting

• 1 other identifier: 2023-268
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the study is to compare a new grafting material for alveolar ridge preservation to a commonly used and well studied material. Alveolar ridge dimensions as well as histology will be compared.

Conditions

Alveolar Ridge Preservation; Dental Extraction; Bone Graft

Outcome Measures

Primary Outcomes (2)

• changes in horizontal dimensions of the alveolar ridge

  Soft and hard tissue horizontal dimensions of the alveolar ridge will be measured after extraction and 4 months later.

  4 months

• changes in vertical dimensions of the alveolar ridge

  Soft and hard tissue vertical dimensions of the alveolar ridge will be measured after extraction and 4 months later.

  4 months

Secondary Outcomes (1)

• vital bone percentage

  4 months

Other Outcomes (6)

• thickness of the buccal plate in mm and its influence on the ridge dimension

  4 months

• the thickness of the lingual plate in mm and its influence on the ridge dimension

  4 months

• the thickness of the overlying buccal soft tissue in mm and its influence on the ridge dimension

  4 months, 1 year

Study Arms (2)

Test Group

EXPERIMENTAL

This group will receive the grafting material that is a combination of DFDBA + DBBM + collagen matrix seal during the alveolar ridge preservation procedure.

Procedure: Alveolar ridge preservation

Control Group

ACTIVE COMPARATOR

This group will receive the grafting material that is a Tutoplast® processed mineralized particulate allograft + collagen matrix seal during the alveolar ridge preservation procedure.

Procedure: Alveolar ridge preservation

Interventions

Alveolar ridge preservation PROCEDURE

Premolar tooth will be extracted flapless and ridge preservation procedure with bone grafting material will be done.

Control Group; Test Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients in good health
• Require the extraction of at least one premolar or molar with future implant placement
• Sufficient keratinized gingiva (equal or more than 2mm prior to extraction),
• No more than 3mm of buccal bone loss
• Flapless extraction possible
• Full mouth plaque index of less than 25%

You may not qualify if:

• Nicotine consumption equivalent to or more than 10 cigarettes per day
• Electronic cigarette usage
• A history of irradiation of head and neck area
• Immunodeficiency disease
• Uncontrolled systemic health problems (hypertension crisis 180/120, hyperthyroidism, diabetes with HbA1c over 7, recent history of stroke, cancer) History of medications that affect bone remodeling process (bisphosphonates, RANK-L inhibitors)
• Previous adverse reaction to the biomaterials used
• Pregnancy/lactation, or those who are trying to become pregnant.
• Active uncontrolled or untreated periodontal disease
• Periapical lesions greater than 1 cm and soft tissue pathology

Sponsors & Collaborators

• Nova Southeastern University: lead
• Geistlich Pharma AG: collaborator
• ZimVie: collaborator

Study Sites (1)

Nova Southeastern University

Fort Lauderdale, Florida, 33328, United States

RECRUITING

Related Publications (45)

• Amler MH. The time sequence of tissue regeneration in human extraction wounds. Oral Surg Oral Med Oral Pathol. 1969 Mar;27(3):309-18. doi: 10.1016/0030-4220(69)90357-0. No abstract available.

  PMID: 5251474 BACKGROUND

• Schropp L, Wenzel A, Kostopoulos L, Karring T. Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent. 2003 Aug;23(4):313-23.

  PMID: 12956475 BACKGROUND

• Buser D, Chappuis V, Belser UC, Chen S. Implant placement post extraction in esthetic single tooth sites: when immediate, when early, when late? Periodontol 2000. 2017 Feb;73(1):84-102. doi: 10.1111/prd.12170.

  PMID: 28000278 BACKGROUND

• Tan WL, Wong TL, Wong MC, Lang NP. A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans. Clin Oral Implants Res. 2012 Feb;23 Suppl 5:1-21. doi: 10.1111/j.1600-0501.2011.02375.x.

  PMID: 22211303 BACKGROUND

• Araujo MG, Lindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol. 2005 Feb;32(2):212-8. doi: 10.1111/j.1600-051X.2005.00642.x.

  PMID: 15691354 BACKGROUND

• Hammerle CH, Chen ST, Wilson TG Jr. Consensus statements and recommended clinical procedures regarding the placement of implants in extraction sockets. Int J Oral Maxillofac Implants. 2004;19 Suppl:26-8. No abstract available.

  PMID: 15635943 BACKGROUND

• Ten Heggeler JM, Slot DE, Van der Weijden GA. Effect of socket preservation therapies following tooth extraction in non-molar regions in humans: a systematic review. Clin Oral Implants Res. 2011 Aug;22(8):779-88. doi: 10.1111/j.1600-0501.2010.02064.x. Epub 2010 Nov 22.

  PMID: 21091540 BACKGROUND

• Avila-Ortiz G, Gubler M, Romero-Bustillos M, Nicholas CL, Zimmerman MB, Barwacz CA. Efficacy of Alveolar Ridge Preservation: A Randomized Controlled Trial. J Dent Res. 2020 Apr;99(4):402-409. doi: 10.1177/0022034520905660. Epub 2020 Feb 12.

  PMID: 32050833 BACKGROUND

• Abellan D, Barallat L, Vilarrasa J, Cabezas M, Pascual La Rocca A, Valles C, Nart J. Ridge preservation in molar sites comparing xenograft versus mineralized freeze-dried bone allograft: A randomized clinical trial. Clin Oral Implants Res. 2022 May;33(5):511-523. doi: 10.1111/clr.13911. Epub 2022 Mar 14.

  PMID: 35218248 BACKGROUND

• Buser D, Martin W, Belser UC. Optimizing esthetics for implant restorations in the anterior maxilla: anatomic and surgical considerations. Int J Oral Maxillofac Implants. 2004;19 Suppl:43-61.

  PMID: 15635945 BACKGROUND

• Canullo L, Tallarico M, Radovanovic S, Delibasic B, Covani U, Rakic M. Distinguishing predictive profiles for patient-based risk assessment and diagnostics of plaque induced, surgically and prosthetically triggered peri-implantitis. Clin Oral Implants Res. 2016 Oct;27(10):1243-1250. doi: 10.1111/clr.12738. Epub 2015 Nov 20.

  PMID: 26584716 BACKGROUND

• Evans CD, Chen ST. Esthetic outcomes of immediate implant placements. Clin Oral Implants Res. 2008 Jan;19(1):73-80. doi: 10.1111/j.1600-0501.2007.01413.x. Epub 2007 Oct 22.

  PMID: 17956569 BACKGROUND

• Araujo MG, Sukekava F, Wennstrom JL, Lindhe J. Ridge alterations following implant placement in fresh extraction sockets: an experimental study in the dog. J Clin Periodontol. 2005 Jun;32(6):645-52. doi: 10.1111/j.1600-051X.2005.00726.x.

  PMID: 15882225 BACKGROUND

• Avila-Ortiz G, Chambrone L, Vignoletti F. Effect of alveolar ridge preservation interventions following tooth extraction: A systematic review and meta-analysis. J Clin Periodontol. 2019 Jun;46 Suppl 21:195-223. doi: 10.1111/jcpe.13057. Erratum In: J Clin Periodontol. 2020 Jan;47(1):129. doi: 10.1111/jcpe.13212.

  PMID: 30623987 BACKGROUND

• Avila-Ortiz G, Elangovan S, Kramer KW, Blanchette D, Dawson DV. Effect of alveolar ridge preservation after tooth extraction: a systematic review and meta-analysis. J Dent Res. 2014 Oct;93(10):950-8. doi: 10.1177/0022034514541127. Epub 2014 Jun 25.

  PMID: 24966231 BACKGROUND

• Darby I, Chen ST, Buser D. Ridge preservation techniques for implant therapy. Int J Oral Maxillofac Implants. 2009;24 Suppl:260-71.

  PMID: 19885449 BACKGROUND

• Khan SN, Cammisa FP Jr, Sandhu HS, Diwan AD, Girardi FP, Lane JM. The biology of bone grafting. J Am Acad Orthop Surg. 2005 Jan-Feb;13(1):77-86.

  PMID: 15712985 BACKGROUND

• Aladmawy MA, Natto ZS, Kreitzer M, Ogata Y, Hur Y. Histological and histomorphometric evaluation of alveolar ridge preservation using an allograft and nonresorbable membrane with and without primary closure: A pilot randomized controlled clinical trial. Medicine (Baltimore). 2022 Jul 1;101(26):e29769. doi: 10.1097/MD.0000000000029769.

  PMID: 35777057 BACKGROUND

• Borg TD, Mealey BL. Histologic healing following tooth extraction with ridge preservation using mineralized versus combined mineralized-demineralized freeze-dried bone allograft: a randomized controlled clinical trial. J Periodontol. 2015 Mar;86(3):348-55. doi: 10.1902/jop.2014.140483. Epub 2014 Nov 21.

  PMID: 25415247 BACKGROUND

• Brugnami F, Then PR, Moroi H, Leone CW. Histologic evaluation of human extraction sockets treated with demineralized freeze-dried bone allograft (DFDBA) and cell occlusive membrane. J Periodontol. 1996 Aug;67(8):821-5. doi: 10.1902/jop.1996.67.8.821.

  PMID: 8866322 BACKGROUND

• Canullo L, Del Fabbro M, Khijmatgar S, Panda S, Ravida A, Tommasato G, Sculean A, Pesce P. Dimensional and histomorphometric evaluation of biomaterials used for alveolar ridge preservation: a systematic review and network meta-analysis. Clin Oral Investig. 2022 Jan;26(1):141-158. doi: 10.1007/s00784-021-04248-1. Epub 2021 Nov 26.

  PMID: 34826029 BACKGROUND

• Cardaropoli D, Tamagnone L, Roffredo A, Gaveglio L, Cardaropoli G. Socket preservation using bovine bone mineral and collagen membrane: a randomized controlled clinical trial with histologic analysis. Int J Periodontics Restorative Dent. 2012 Aug;32(4):421-30.

  PMID: 22577648 BACKGROUND

• Chan HL, Lin GH, Fu JH, Wang HL. Alterations in bone quality after socket preservation with grafting materials: a systematic review. Int J Oral Maxillofac Implants. 2013 May-Jun;28(3):710-20. doi: 10.11607/jomi.2913.

  PMID: 23748301 BACKGROUND

• Corning PJ, Mealey BL. Ridge preservation following tooth extraction using mineralized freeze-dried bone allograft compared to mineralized solvent-dehydrated bone allograft: A randomized controlled clinical trial. J Periodontol. 2019 Feb;90(2):126-133. doi: 10.1002/JPER.18-0199. Epub 2018 Sep 19.

  PMID: 30161278 BACKGROUND

• De Risi V, Clementini M, Vittorini G, Mannocci A, De Sanctis M. Alveolar ridge preservation techniques: a systematic review and meta-analysis of histological and histomorphometrical data. Clin Oral Implants Res. 2015 Jan;26(1):50-68. doi: 10.1111/clr.12288. Epub 2013 Nov 1.

  PMID: 27007188 BACKGROUND

• Demetter RS, Calahan BG, Mealey BL. Histologic Evaluation of Wound Healing After Ridge Preservation With Cortical, Cancellous, and Combined Cortico-Cancellous Freeze-Dried Bone Allograft: A Randomized Controlled Clinical Trial. J Periodontol. 2017 Sep;88(9):860-868. doi: 10.1902/jop.2017.170155. Epub 2017 Apr 28.

  PMID: 28452622 BACKGROUND

• Eskow AJ, Mealey BL. Evaluation of healing following tooth extraction with ridge preservation using cortical versus cancellous freeze-dried bone allograft. J Periodontol. 2014 Apr;85(4):514-24. doi: 10.1902/jop.2013.130178. Epub 2013 May 31.

  PMID: 23725026 BACKGROUND

• Froum S, Cho SC, Rosenberg E, Rohrer M, Tarnow D. Histological comparison of healing extraction sockets implanted with bioactive glass or demineralized freeze-dried bone allograft: a pilot study. J Periodontol. 2002 Jan;73(1):94-102. doi: 10.1902/jop.2002.73.1.94.

  PMID: 11846205 BACKGROUND

• Iasella JM, Greenwell H, Miller RL, Hill M, Drisko C, Bohra AA, Scheetz JP. Ridge preservation with freeze-dried bone allograft and a collagen membrane compared to extraction alone for implant site development: a clinical and histologic study in humans. J Periodontol. 2003 Jul;74(7):990-9. doi: 10.1902/jop.2003.74.7.990.

  PMID: 12931761 BACKGROUND

• Nelson AC, Mealey BL. A randomized controlled trial on the impact of healing time on wound healing following ridge preservation using a 70%/30% combination of mineralized and demineralized freeze-dried bone allograft. J Periodontol. 2020 Oct;91(10):1256-1263. doi: 10.1002/JPER.19-0610. Epub 2020 Mar 3.

  PMID: 32052432 BACKGROUND

• Poulias E, Greenwell H, Hill M, Morton D, Vidal R, Shumway B, Peterson TL. Ridge preservation comparing socket allograft alone to socket allograft plus facial overlay xenograft: a clinical and histologic study in humans. J Periodontol. 2013 Nov;84(11):1567-75. doi: 10.1902/jop.2013.120585. Epub 2013 Jan 23.

  PMID: 23339378 BACKGROUND

• Sadeghi R, Babaei M, Miremadi SA, Abbas FM. A randomized controlled evaluation of alveolar ridge preservation following tooth extraction using deproteinized bovine bone mineral and demineralized freeze-dried bone allograft. Dent Res J (Isfahan). 2016 Mar-Apr;13(2):151-9. doi: 10.4103/1735-3327.178202.

  PMID: 27076830 BACKGROUND

• Saito H, Couso-Queiruga E, Shiau HJ, Stuhr S, Prasad H, Allareddy TV, Reynolds MA, Avila-Ortiz G. Evaluation of poly lactic-co-glycolic acid-coated beta-tricalcium phosphate for alveolar ridge preservation: A multicenter randomized controlled trial. J Periodontol. 2021 Apr;92(4):524-535. doi: 10.1002/JPER.20-0360. Epub 2020 Oct 12.

  PMID: 32996128 BACKGROUND

• Scheyer ET, Heard R, Janakievski J, Mandelaris G, Nevins ML, Pickering SR, Richardson CR, Pope B, Toback G, Velasquez D, Nagursky H. A randomized, controlled, multicentre clinical trial of post-extraction alveolar ridge preservation. J Clin Periodontol. 2016 Dec;43(12):1188-1199. doi: 10.1111/jcpe.12623. Epub 2016 Oct 21.

  PMID: 27617409 BACKGROUND

• Serrano Mendez CA, Lang NP, Caneva M, Ramirez Lemus G, Mora Solano G, Botticelli D. Comparison of allografts and xenografts used for alveolar ridge preservation. A clinical and histomorphometric RCT in humans. Clin Implant Dent Relat Res. 2017 Aug;19(4):608-615. doi: 10.1111/cid.12490. Epub 2017 May 2.

  PMID: 28466494 BACKGROUND

• Suarez-Lopez Del Amo F, Monje A. Efficacy of biologics for alveolar ridge preservation/reconstruction and implant site development: An American Academy of Periodontology best evidence systematic review. J Periodontol. 2022 Dec;93(12):1827-1847. doi: 10.1002/JPER.22-0069. Epub 2022 Oct 24.

  PMID: 35841608 BACKGROUND

• Toloue SM, Chesnoiu-Matei I, Blanchard SB. A clinical and histomorphometric study of calcium sulfate compared with freeze-dried bone allograft for alveolar ridge preservation. J Periodontol. 2012 Jul;83(7):847-55. doi: 10.1902/jop.2011.110470. Epub 2011 Dec 13.

  PMID: 22166162 BACKGROUND

• Wang HL, Tsao YP. Histologic evaluation of socket augmentation with mineralized human allograft. Int J Periodontics Restorative Dent. 2008 Jun;28(3):231-7.

  PMID: 18605598 BACKGROUND

• Whetman J, Mealey BL. Effect of Healing Time on New Bone Formation After Tooth Extraction and Ridge Preservation With Demineralized Freeze-Dried Bone Allograft: A Randomized Controlled Clinical Trial. J Periodontol. 2016 Sep;87(9):1022-9. doi: 10.1902/jop.2016.160139. Epub 2016 Apr 30.

  PMID: 27133791 BACKGROUND

• Wood RA, Mealey BL. Histologic comparison of healing after tooth extraction with ridge preservation using mineralized versus demineralized freeze-dried bone allograft. J Periodontol. 2012 Mar;83(3):329-36. doi: 10.1902/jop.2011.110270. Epub 2011 Jul 12.

  PMID: 21749166 BACKGROUND

• Zampara E, Alshammari M, De Bortoli J, Mullings O, Gkisakis IG, Benalcazar Jalkh EB, Tovar N, Coelho PG, Witek L. A Histologic and Histomorphometric Evaluation of an Allograft, Xenograft, and Alloplast Graft for Alveolar Ridge Preservation in Humans: A Randomized Controlled Clinical Trial. J Oral Implantol. 2022 Dec 1;48(6):541-549. doi: 10.1563/aaid-joi-D-21-00012.

  PMID: 35446950 BACKGROUND

• Zellner JW, Allen HT, Kotsakis GA, Mealey BL. Wound healing after ridge preservation: A randomized controlled trial on short-term (4 months) versus long-term (12 months) histologic outcomes. J Periodontol. 2023 May;94(5):622-629. doi: 10.1002/JPER.22-0187. Epub 2023 Jan 10.

  PMID: 36527199 BACKGROUND

• Canellas JVDS, Soares BN, Ritto FG, Vettore MV, Vidigal Junior GM, Fischer RG, Medeiros PJD. What grafting materials produce greater alveolar ridge preservation after tooth extraction? A systematic review and network meta-analysis. J Craniomaxillofac Surg. 2021 Nov;49(11):1064-1071. doi: 10.1016/j.jcms.2021.06.005. Epub 2021 Jun 19.

  PMID: 34176715 BACKGROUND

• Mayer Y, Ginesin O, Zigdon-Giladi H. Socket Preservation Using Xenograft Does Not Impair Implant Primary Stability in Sheep: Clinical, Histological, and Histomorphometric Study. J Oral Implantol. 2020 Dec 1;46(6):580-588. doi: 10.1563/aaid-joi-D-19-00237.

  PMID: 32315436 BACKGROUND

• Monje A, Ravida A, Wang HL, Helms JA, Brunski JB. Relationship Between Primary/Mechanical and Secondary/Biological Implant Stability. Int J Oral Maxillofac Implants. 2019 Suppl;34:s7-s23. doi: 10.11607/jomi.19suppl.g1.

  PMID: 31116830 BACKGROUND

Central Study Contacts

Andee Goldstein, DMD

CONTACT

7542599445; ag3577@mynsu.nova.edu

Fatemeh Samavatijame, DMD

CONTACT

(734) 546-9018‬; fs724@mynsu.nova.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 7, 2024
• First Posted: February 23, 2024
• Study Start: January 26, 2024
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): June 1, 2026
• Last Updated: September 12, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)