Traditional vs Orthodontic Extraction of Impacted Teeth Related to the Inferior Alveolar Nerve

NCT06270784 | Completed

• 1 other identifier: 09.2024.122
• Study Type: interventional
• Target: 46
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this clinical study was to compare the effects of traditional and orthodontic extraction methods on postoperative nerve damage in impacted third molars associated with the inferior alveolar nerve. The main question it aims to answer is:

• Does the orthodontic extraction method reduce the risk of nerve injury compared to traditional extraction? Participants will:
• undergo either traditional or orthodontic extraction
• be monitored for postoperative paresthesia. Researchers will compare traditional and orthodontic extraction methods to see if extraction methods affect postoperative nerve damage.

Conditions

Inferior Alveolar Nerve Injuries

Keywords

Mandibular nerve injuries, impacted teeth, tooth extraction

Outcome Measures

Primary Outcomes (1)

• 2-point discrimination test on the 7th day after surgery

  The primary outcome measure of the study was the assessment of nerve injury. For this purpose, postoperative nerve injury will be recorded by a 2-point discrimination test with the help of a caliper with a 1mm gap.

  A 2-point discrimination test will be performed before the extraction and 7 days after extraction in both groups.

Secondary Outcomes (3)

• Visual Analog Score(VAS)

  VAS will be evaluated on the 7th and 14th postoperative days and the 1st, 3rd, and 6th months after tooth extraction.

• 2-point discrimination test on the 14th days and the 1st, 3rd, and 6th months after extraction.

  A 2-point discrimation test will be performed on the 14th days and the 1st, 3rd, and 6th months after extraction.

• Inferior alveolar nerve recovery

  Inferior alveolar nerve recovery will be assessed on the 7th and 14th postoperative days and the 1st, 3rd, and 6th months after tooth extraction.

Study Arms (2)

Traditional Extraction Group

ACTIVE COMPARATOR

Procedure: Traditional Extraction

Orthodontic Extraction Group

EXPERIMENTAL

Procedure: Orthodontic Extraction

Interventions

Traditional Extraction PROCEDURE

Participants in this group will undergo traditional extraction method. This method involves uncovering the impacted tooth and extracting the tooth with or without dividing it.

Traditional Extraction Group

Orthodontic Extraction PROCEDURE

Participants in this group will undergo orthodontic extraction method. In this method, a two-stage surgical procedure will be performed. In the first operation, the impacted tooth will be uncovered, and then a button will be placed on the tooth. For anchorage purposes, orthodontic mini screws will be placed in the mandibular ramus or zygomaticomaxillary buttress area. Elastics and/or ligature wires fixed to the button will be attached to the mini screw to provide force for the traction of the tooth. Patients will be called for check-up appointments every two weeks, and the movement of the impacted tooth will be monitored with panoramic x-rays. The second operation will be planned when the tooth moves away from the inferior alveolar nerve. In the second operation, the tooth will be extracted in a similar way to the traditional extraction group.

Orthodontic Extraction Group

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Presence of indication for wisdom tooth extraction for reasons such as pericoronitis, pathological formation, orthodontic reasons, caries, etc.
• Mandibular impacted wisdom teeth close to the inferior alveolar nerve

You may not qualify if:

• Mandibular impacted wisdom tooth not close to inferior alveolar nerve
• Wisdom tooth whose apexification has not yet been completed
• Suspicion of a malignant pathological lesion
• Pathological lesion associated with inferior alveolar nerve
• Presence of an acute infection

Sponsors & Collaborators

• Marmara University: lead

Study Sites (1)

Marmara University

Istanbul, Basibuyuk, 34854, Turkey (Türkiye)

Location

Related Publications (1)

• Askin Ekinci S, Kiristioglu ZB, Ates O, Gocmen G. Traditional vs. orthodontic extraction of impacted teeth related to the inferior alveolar nerve: a randomized control trial. BMC Oral Health. 2025 Jul 2;25(1):1036. doi: 10.1186/s12903-025-06402-7.

  PMID: 40604669 DERIVED

MeSH Terms

Conditions

Mandibular Nerve Injuries; Tooth, Impacted

Condition Hierarchy (Ancestors)

Trigeminal Nerve Injuries; Trigeminal Nerve Diseases; Facial Neuralgia; Facial Nerve Diseases; Mouth Diseases; Stomatognathic Diseases; Cranial Nerve Injuries; Cranial Nerve Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries; Tooth Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 13, 2024
• First Posted: February 21, 2024
• Study Start: January 17, 2024
• Primary Completion: May 6, 2024
• Study Completion: November 6, 2024
• Last Updated: May 7, 2025

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)