Effects of Blood Flow Restriction Training on Exercises in Healthy Individuals.

NCT06254586 | Completed DMC

• 1 other identifier: THIAGU 01
• Study Type: interventional
• Target: 480
• Locations: 1 country
• Sites: 1

Brief Summary

Partial restriction of blood flow to working muscles during exercise is proven to increase muscle mass and strength even with low-intensity of exercise. Blood Flow Restriction Training (BFRT) is also beneficial to improve the maximum rate of oxygen consumption (VO2max), bone health, and vascular health. Recent studies focus on its effects beyond the musculoskeletal system. Post-exercise hypotension is a known acute physiological response that happens after intense exercise. Early studies demonstrated BFRT might amplify the acute hypotensive effects with low intensity of exercise. However, it's not clear what type of exercise would help to lower blood pressure when it is combined with BFRT.

Conditions

Health, Subjective

Keywords

Blood flow Restriction Training; Blood Pressure; Heart Rate; Mean Arterial Pressure; Muscle Girth

Outcome Measures

Primary Outcomes (24)

• Heart rate

  The chest strap heart rate monitors can continuously monitor heart rate throughout the day. These devices use optical sensors or electrodes to detect changes in blood flow and provide real-time data.

  Baseline

• Heart rate

  The chest strap heart rate monitors can continuously monitor heart rate throughout the day. These devices use optical sensors or electrodes to detect changes in blood flow and provide real-time data.

  After 1 minute

• Heart rate

  The chest strap heart rate monitors can continuously monitor heart rate throughout the day. These devices use optical sensors or electrodes to detect changes in blood flow and provide real-time data.

  After 3 minutes

• Heart rate

  The chest strap heart rate monitors can continuously monitor heart rate throughout the day. These devices use optical sensors or electrodes to detect changes in blood flow and provide real-time data.

  After 5 minutes

• Heart rate

  The chest strap heart rate monitors can continuously monitor heart rate throughout the day. These devices use optical sensors or electrodes to detect changes in blood flow and provide real-time data.

  After 15 minutes

• Heart rate

  The chest strap heart rate monitors can continuously monitor heart rate throughout the day. These devices use optical sensors or electrodes to detect changes in blood flow and provide real-time data.

  After 30 minutes

• Blood pressure

  BP monitor devices use an inflatable cuff to measure blood pressure and detect pulsations to determine the heart rate.

  Baseline

• Blood pressure

  BP monitor devices use an inflatable cuff to measure blood pressure and detect pulsations to determine the heart rate.

  After 1 minute

• Blood pressure

  BP monitor devices use an inflatable cuff to measure blood pressure and detect pulsations to determine the heart rate.

  After 3 minutes

• Blood pressure

  BP monitor devices use an inflatable cuff to measure blood pressure and detect pulsations to determine the heart rate.

  After 5 minutes

• Blood pressure

  BP monitor devices use an inflatable cuff to measure blood pressure and detect pulsations to determine the heart rate.

  After 15 minutes

• Blood pressure

  BP monitor devices use an inflatable cuff to measure blood pressure and detect pulsations to determine the heart rate.

  After 30 minutes

• Mean arterial pressure

  Mean arterial pressure monitor devices use an inflatable cuff to measure blood pressure and detect pulsations to determine the heart rate.

  Baseline

• Mean arterial pressure

  Mean arterial pressure monitor devices use an inflatable cuff to measure blood pressure and detect pulsations to determine the heart rate.

  After 1 minute

• Mean arterial pressure

  Mean arterial pressure monitor devices use an inflatable cuff to measure blood pressure and detect pulsations to determine the heart rate.

  After 3 minutes

• Mean arterial pressure

  Mean arterial pressure monitor devices use an inflatable cuff to measure blood pressure and detect pulsations to determine the heart rate.

  After 5 minutes

• Mean arterial pressure

  Mean arterial pressure monitor devices use an inflatable cuff to measure blood pressure and detect pulsations to determine the heart rate.

  After 15 minutes

• Mean arterial pressure

  Mean arterial pressure monitor devices use an inflatable cuff to measure blood pressure and detect pulsations to determine the heart rate.

  After 30 minutes

• Muscle girth

  For biceps measurement, the individual should flex their arm at a 90-degree angle. Place the tape measure around the midpoint of the upper arm, making sure it is snug but not tight. Record the measurement in inches or centimeters.

  Baseline

• Muscle girth

  For biceps measurement, the individual should flex their arm at a 90-degree angle. Place the tape measure around the midpoint of the upper arm, making sure it is snug but not tight. Record the measurement in inches or centimeters.

  After 1 minute

• Muscle girth

  For biceps measurement, the individual should flex their arm at a 90-degree angle. Place the tape measure around the midpoint of the upper arm, making sure it is snug but not tight. Record the measurement in inches or centimeters.

  After 3 minutes

• Muscle girth

  For biceps measurement, the individual should flex their arm at a 90-degree angle. Place the tape measure around the midpoint of the upper arm, making sure it is snug but not tight. Record the measurement in inches or centimeters.

  After 5 minutes

• Muscle girth

  For biceps measurement, the individual should flex their arm at a 90-degree angle. Place the tape measure around the midpoint of the upper arm, making sure it is snug but not tight. Record the measurement in inches or centimeters.

  After 15 minutes

• Muscle girth

  For biceps measurement, the individual should flex their arm at a 90-degree angle. Place the tape measure around the midpoint of the upper arm, making sure it is snug but not tight. Record the measurement in inches or centimeters.

  After 30 minutes

Study Arms (2)

Aerobic exercise

EXPERIMENTAL

This group received a single session of low-intensity cycling for 20 minutes.

Procedure: Aerobic exercises

Resisted exercises

ACTIVE COMPARATOR

This group received four sets of 15 repetitions of knee extension, hamstring curls, and standing calf raises (20-40% 1RM) with a 30 sec to 1 minute rest period between sets.

Procedure: Resisted exercises

Interventions

Aerobic exercises PROCEDURE

This group received a single session of low-intensity cycling for 20 minutes. A period of reperfusion (3 to 5 minutes) were provided in both groups after 10 minutes of exercise training by deflating the BFR cuffs. The cuffs were inflated after 5 minutes of reperfusion, and the exercises were completed in both groups.

Aerobic exercise

Resisted exercises PROCEDURE

This group received four sets of 15 repetitions of knee extension, hamstring curls, and standing calf raises (20-40% 1RM) with 30 sec to 1 minute rest period between sets. A period of reperfusion (3 to 5 minutes) were provided in both groups after 10 minutes of exercise training by deflating the BFR cuffs. The cuffs were inflated after 5 minutes of reperfusion, and the exercises were completed in both groups.

Resisted exercises

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy adults of both gender, between the ages of 18 and 35 years
• Adults who are not participating in any regular exercise/fitness programmes for the last three months

You may not qualify if:

• Adults with previous history of cardiovascular diseases, or with pathological changes in ECG
• Adults with concomitant illness such as diabetes, hypertension, or kidney diseases
• Chronic smokers or alcoholics
• Those with recent history of injury to lower limbs or with implants in lower limbs

Sponsors & Collaborators

• Prince Sattam Bin Abdulaziz University: lead

Study Sites (1)

Gopal Nambi

Al Kharj, Riyadh Region, 11942, Saudi Arabia

Location

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Gopal Nambi, PhD

  Prince Sattam Bin Abdulaziz University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 3, 2024
• First Posted: February 12, 2024
• Study Start: April 1, 2022
• Primary Completion: October 30, 2023
• Study Completion: October 30, 2023
• Last Updated: February 12, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

SA (1)