Compare Outcomes After High and Low Ligation of Inferior Mesenteric Artery in Colorectal Cancer

NCT06253949 | Recruiting

• 1 other identifier: Soh-Med-24-01-01MD
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

We aim comparing different outcomes between high and low tie ligation of inferior mesenteric artery in left colorectal cancer operable and elective surgeries.

Conditions

Colon Cancer

Keywords

colon cancer; high tie; low tie; inferior mesenteric artery

Outcome Measures

Primary Outcomes (3)

• anastomotic leakage

  yes or no

  2 weeks postoperative

• hemorrhage

  yes or no

  2 weeks postoperative

• rectal cancer-low anterior resection syndrome (LARS)

  yes or no

  2 weeks postoperative

Secondary Outcomes (1)

• 1-year overall survival

  one year

Study Arms (2)

high tie ligation of inferior mesenteric artery

ACTIVE COMPARATOR

Group A patients of elective operable colorectal cancer : high tie group

Procedure: ligation of inferior mesenteric artery in colorectal cancer

low tie ligation of inferior mesenteric artery

ACTIVE COMPARATOR

Group B patients of elective operable colorectal cancer : low tie group

Procedure: ligation of inferior mesenteric artery in colorectal cancer

Interventions

ligation of inferior mesenteric artery in colorectal cancer PROCEDURE

This study will include two groups of patients: group (A) and (B). In group (A), the inferior mesenteric artery will be ligated at its origin (high-tie), While in group (B), it will be ligated after the origin of the left colic artery (low-tie).

high tie ligation of inferior mesenteric artery; low tie ligation of inferior mesenteric artery

Eligibility Criteria

• Age: 15 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Every elective patient diagnosed with left-side colon or rectal cancer will be included in our study.

You may not qualify if:

• Unfit patients with uncontrolled medical disease will be excluded. Patients with acute intestinal obstruction (emergency cases) and patients with extremes of age above 75 or pediatric ages will be excluded.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag University

Sohag, 82511, Egypt

RECRUITING

MeSH Terms

Conditions

Colonic Neoplasms

Condition Hierarchy (Ancestors)

Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases

Study Officials

• Mohamed R Mohamed, MD

  Sohag University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mohamed R Mohamed, MD

CONTACT

01128056501; mohamed_mourad1@med.sohag.edu.eg

Emad A Ahmed, MD

CONTACT

01128056501; mohamed_mourad1@med.sohag.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer of General Surgery Faculty of Medicine

Study Record Dates

• First Submitted: February 4, 2024
• First Posted: February 12, 2024
• Study Start: December 1, 2023
• Primary Completion: October 1, 2024
• Study Completion: December 1, 2024
• Last Updated: February 12, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)