NCT06248268

Brief Summary

The present study consists of 3 projects in total and aims to investigate the (neuro-) psychological patterns from suicidal ideation to suicidal behavior as well as the effects and feasibility of ASSIP Home Treatment. The overall aim of project 1 is to determine (neuro-) psychological differences between suicide attempters, suicide ideators, a clinical control group, and healthy controls. Study participants in project 1 will participate in a one-time (neuro-) psychological assessment. Project 1 of this study is an observational cross-sectional study with four groups that will be conducted at the University Hospital of Psychiatry and Psychotherapy Bern (Switzerland): Patients with at least one suicide attempt in their past (SUAT), patients with suicidal ideation (SUID), patients from the same clinical cohort, without neither suicidal behavior or ideation (CLIN) and the healthy group (HLTH). The cohorts to be examined (SUAT \& SUID) will be compared to the two control groups (CLIN \& HLTH). Only people who have signed the informed consent and meet the eligibility criteria can participate in this study.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
180

participants targeted

Target at P50-P75 for all trials

Timeline
6mo left

Started Aug 2024

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress77%
Aug 2024Dec 2026

First Submitted

Initial submission to the registry

March 13, 2023

Completed
11 months until next milestone

First Posted

Study publicly available on registry

February 8, 2024

Completed
6 months until next milestone

Study Start

First participant enrolled

August 8, 2024

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2026

Last Updated

January 16, 2026

Status Verified

January 1, 2026

Enrollment Period

2.4 years

First QC Date

March 13, 2023

Last Update Submit

January 15, 2026

Conditions

Inhibitory ControlLocus of ControlSelf EfficacySuicide, AttemptedSuicidal IdeationAttention

Outcome Measures

Primary Outcomes (1)

  • Differences in Inhibitory Control

    The Go/No-Go task is a cognitive task to assess an individual's ability to inhibit a prepotent response. It is used to measure impulse control and response inhibition. The task requires participants to respond ("Go" response) to one type of stimulus and to withhold or inhibit their response ("No-Go" response) to another type of stimulus. The Go/No-Go task yields measures such as reaction time, accuracy, and the ability to inhibit responses. Reaction times can vary widely, and accuracy is often expressed as a percentage of correct responses. Lower reaction times and higher accuracy in withholding responses (No-Go trials) indicate better inhibitory control and cognitive performance.

    The assessment takes place 1 day to 1 week after informed consent.

Secondary Outcomes (1)

  • Selective Attention and Interference Control

    The assessment takes place 1 day to 1 week after informed consent.

Other Outcomes (16)

  • Mental abilities like attention, working memory and visuomotor speed as well as mental flexibility

    The assessment takes place 1 day to 1 week after informed consent.

  • Attention and Concentration Abilities

    The assessment takes place 1 day to 1 week after informed consent.

  • Sociodemographic data

    The assessment takes place 1 day to 1 week after informed consent.

  • +13 more other outcomes

Study Arms (4)

Suicide attempters

Patients with at least one previous suicide attempt

Other: (Neuro-)psychological assessment

Suicide ideators

Patients with suicidal thoughts, but no previous suicide attempt

Other: (Neuro-)psychological assessment

Clinical control group

Patients without suicidal behavior and thoughts

Other: (Neuro-)psychological assessment

Healthy controls

Healthy persons without suicidal behavior and thoughts

Other: (Neuro-)psychological assessment

Interventions

(Neuro-)psychological assessmentOTHER

The measurement, which takes place 1 week after the informed consent, aims to determine the distinct (neuro-) psychological patterns of suicidal behavior versus suicidal ideation, in comparison to two control groups.

Clinical control groupHealthy controlsSuicide attemptersSuicide ideators

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

This quantitative cross-sectional study with four groups will be conducted at the University Hospital of Psychiatry and Psychotherapy, Bern. Patients with at least one suicide attempt in their past (SUAT), patients with suicidal ideation (SUID), patients from the same clinical cohort without neither suicidal behavior or ideation (CLIN), and the healthy group (HLTH). The cohorts to be examined (SUAT \& SUID) will be compared to two control groups (CLIN \& HLTH).

You may qualify if:

  • Informed consent as documented by signature
  • Age ≥ 18 years
  • At least one previous suicide attempt
  • Suicidal ideation

You may not qualify if:

  • Serious cognitive impairment
  • Any current psychotic disorder
  • Any current medication, which substantially impairs the attention span, reaction rate or any other relevant cognitive functions
  • Inability to follow the procedures of the study (e.g., insufficient mastery of the German language, previous enrolment into the current study)
  • Previous suicidal behavior
  • Previous suicidal behavior
  • Suicidal ideation
  • Current psychiatric disorder treated on an inpatient, day-care or outpatient basis

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital of Psychiatry and Psychotherapy, University of Bern

Bern, 3008, Switzerland

RECRUITING

Related Publications (17)

  • Peter, C. and A. Tuch, Suizidgedanken und Suizidversuche in der Schweizer Bevölkerung. Obsan Bulletin. Vol. 7. 2019, Nêuchatel. 2019.

    BACKGROUND

  • Bostwick JM, Pabbati C, Geske JR, McKean AJ. Suicide Attempt as a Risk Factor for Completed Suicide: Even More Lethal Than We Knew. Am J Psychiatry. 2016 Nov 1;173(11):1094-1100. doi: 10.1176/appi.ajp.2016.15070854. Epub 2016 Aug 13.

    PMID: 27523496BACKGROUND

  • Ystgaard M, Arensman E, Hawton K, Madge N, van Heeringen K, Hewitt A, de Wilde EJ, De Leo D, Fekete S. Deliberate self-harm in adolescents: comparison between those who receive help following self-harm and those who do not. J Adolesc. 2009 Aug;32(4):875-91. doi: 10.1016/j.adolescence.2008.10.010. Epub 2008 Nov 22.

    PMID: 19028399BACKGROUND

  • Klonsky ED, May A. Rethinking impulsivity in suicide. Suicide Life Threat Behav. 2010 Dec;40(6):612-9. doi: 10.1521/suli.2010.40.6.612.

    PMID: 21198330BACKGROUND

  • May, A.M. and E.D. Klonsky, What distinguishes suicide attempters from suicide ideators? A meta-analysis of potential factors. Clinical Psychology: Science and Practice, 2016. 23(1): p. 5.

    BACKGROUND

  • Lizardi D, Stanley B. Treatment engagement: a neglected aspect in the psychiatric care of suicidal patients. Psychiatr Serv. 2010 Dec;61(12):1183-91. doi: 10.1176/ps.2010.61.12.1183.

    PMID: 21123401BACKGROUND

  • Smith JL, Mattick RP, Jamadar SD, Iredale JM. Deficits in behavioural inhibition in substance abuse and addiction: a meta-analysis. Drug Alcohol Depend. 2014 Dec 1;145:1-33. doi: 10.1016/j.drugalcdep.2014.08.009. Epub 2014 Aug 24.

    PMID: 25195081BACKGROUND

  • Nock MK, Park JM, Finn CT, Deliberto TL, Dour HJ, Banaji MR. Measuring the suicidal mind: implicit cognition predicts suicidal behavior. Psychol Sci. 2010 Apr;21(4):511-7. doi: 10.1177/0956797610364762. Epub 2010 Mar 9.

    PMID: 20424092BACKGROUND

  • MacLeod CM, MacDonald PA. Interdimensional interference in the Stroop effect: uncovering the cognitive and neural anatomy of attention. Trends Cogn Sci. 2000 Oct 1;4(10):383-391. doi: 10.1016/s1364-6613(00)01530-8.

    PMID: 11025281BACKGROUND

  • Reitan, R.M. and D. Wolfson, Category Test and Trail Making Test as measures of frontal lobe functions. The Clinical Neuropsychologist, 1995. 9(1): p. 50-56.

    BACKGROUND

  • Schwarzer, R. and M. Jerusalem, Skala zur allgemeinen Selbstwirksamkeitserwartung. 1999, Berlin: Freie Universität Berlin. 2013.

    BACKGROUND

  • Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57.

    PMID: 9881538BACKGROUND

  • Beck AT, Steer RA, Ranieri WF. Scale for Suicide Ideation: psychometric properties of a self-report version. J Clin Psychol. 1988 Jul;44(4):499-505. doi: 10.1002/1097-4679(198807)44:43.0.co;2-6.

    PMID: 3170753BACKGROUND

  • Mee S, Bunney BG, Bunney WE, Hetrick W, Potkin SG, Reist C. Assessment of psychological pain in major depressive episodes. J Psychiatr Res. 2011 Nov;45(11):1504-10. doi: 10.1016/j.jpsychires.2011.06.011. Epub 2011 Aug 9.

    PMID: 21831397BACKGROUND

  • Hautzinger, M., et al., Beck-depressions-inventar (BDI). Bearbeitung der deutschen Ausgabe. Testhandbuch. Bern: Huber, 1994.

    BACKGROUND

  • Hughes ME, Waite LJ, Hawkley LC, Cacioppo JT. A Short Scale for Measuring Loneliness in Large Surveys: Results From Two Population-Based Studies. Res Aging. 2004;26(6):655-672. doi: 10.1177/0164027504268574.

    PMID: 18504506BACKGROUND

  • Russell D, Peplau LA, Cutrona CE. The revised UCLA Loneliness Scale: concurrent and discriminant validity evidence. J Pers Soc Psychol. 1980 Sep;39(3):472-80. doi: 10.1037//0022-3514.39.3.472.

    PMID: 7431205BACKGROUND

MeSH Terms

Conditions

Suicide, AttemptedSuicidal Ideation

Condition Hierarchy (Ancestors)

SuicideSelf-Injurious BehaviorBehavioral SymptomsBehavior

Study Officials

  • Anja C. Gysin-Maillart, PD Dr. phil.

    University of Bern, University Hospital of Psychiatry, Translational Research Center

    PRINCIPAL INVESTIGATOR

  • Lara M. Aschenbrenner, M.Sc.

    University of Bern, University Hospital of Psychiatry, Translational Research Center

    STUDY CHAIR

Central Study Contacts

Anja C. Gysin-Maillart, PD Dr. phil.

CONTACT

+41 (0) 31 632 88 11anja.gysin-maillart@unibe.ch

Kristina Adorjan, Prof. Dr. med.

CONTACT

+41 (0) 58 630 91 11kristina.adorjan@unibe.ch

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 13, 2023

First Posted

February 8, 2024

Study Start

August 8, 2024

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2026

Last Updated

January 16, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will not share

Locations

CH(1)