Identification of Prognostic Factors and Role of Radiotherapy in Patients With Ewing Sarcoma

NCT06243588 | Recruiting

• 1 other identifier: ProEwing
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

assess whether there is a correlation between some factors (age, sex, tumor volume, tumor site, chemotherapy-induced necrosis, radiation and biomarkers) and overall survival (OS) and relapse-free survival (RFS) in patients with Ewing sarcoma. Identification of reliable prognostic factors could help to identify high-risk patients, which may require a different treatment and follow up.

Conditions

Ewing Sarcoma

Outcome Measures

Primary Outcomes (1)

• Correlation

  Correlation between some factors (age, sex, tumor volume, tumor site, chemotherapy-induced necrosis, radiation and biomarkers) and overall survival (OS) and relapse-free survival (RFS) in patients with Ewing sarcoma.

  At baseline (Day 0)

Study Arms (1)

Patients

patients treated at Rizzoli Institute from 1991 to 2021.

Other: clinical records review

Interventions

clinical records review OTHER

review the medical records, radiological imaging, and histological data of these patients

Patients

Eligibility Criteria

• Age: 2 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Male and female patients treated at Rizzoli Orthopaedic Institute between 01/01/1991 and 31/12/2021

You may qualify if:

• Male and female patients treated at Rizzoli Orthopaedic Institute between 01/01/1991 and 31/12/2021
• Age ≥ 2 years
• Diagnosis of Ewing Sarcoma
• Patients with available clinical and imaging data

Sponsors & Collaborators

• Istituto Ortopedico Rizzoli: lead

Study Sites (1)

IRCCS Itituto Ortopedico Rizzoli

Bologna, BO, 40136, Italy

RECRUITING

Related Publications (2)

• Grunewald TGP, Cidre-Aranaz F, Surdez D, Tomazou EM, de Alava E, Kovar H, Sorensen PH, Delattre O, Dirksen U. Ewing sarcoma. Nat Rev Dis Primers. 2018 Jul 5;4(1):5. doi: 10.1038/s41572-018-0003-x.

  PMID: 29977059 RESULT

• Pressman BD, Tourje EJ, Thompson JR. An early CT sign of ischemic infarction: increased density in a cerebral artery. AJR Am J Roentgenol. 1987 Sep;149(3):583-6. doi: 10.2214/ajr.149.3.583.

  PMID: 3497548 RESULT

MeSH Terms

Conditions

Sarcoma, Ewing

Condition Hierarchy (Ancestors)

Osteosarcoma; Neoplasms, Bone Tissue; Neoplasms, Connective Tissue; Neoplasms, Connective and Soft Tissue; Neoplasms by Histologic Type; Neoplasms; Sarcoma

Central Study Contacts

Costantino Errani

CONTACT

0516366; costantino.errani@ior.it

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 29, 2024
• First Posted: February 6, 2024
• Study Start: January 25, 2024
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: March 5, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)