Pyroptosis and Ferroptosis in the Pathophysiology of Lymphedema
The Role of Pyroptosis and Ferroptosis in the Pathophysiology of Lymphedema
1 other identifier
observational
120
1 country
1
Brief Summary
The project aims to compare the differences in the expression of cell death through apoptosis and iron-dependent cell death after the reduction of edema symptoms following lymphedema surgery in patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Sep 2023
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 20, 2023
CompletedFirst Submitted
Initial submission to the registry
January 16, 2024
CompletedFirst Posted
Study publicly available on registry
February 2, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 20, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
January 12, 2026
CompletedFebruary 2, 2024
September 1, 2023
1 year
January 16, 2024
January 24, 2024
Conditions
Outcome Measures
Primary Outcomes (1)
The correlation between post-LVA volume reduction
The differences in expression of cell necrosis and iron-dependent cell death after lymphedema surgery were observed in patients, following alleviation of edema symptoms.
1 month after surgery
Study Arms (1)
Patients underwent surgery
Interventions
Patients who have developed lymphedema and undergone lymphedema surgery.
For patients who have not experienced lymphedema but require surgery due to other disease such as cancer, trauma, chronic wounds, skin defects, etc.
Eligibility Criteria
Patients as experimental group who has lymphedema and need to underwent surgery. Patients as control group who require surgery without lymphedema. Written informed consent was obtained from all patients.
You may qualify if:
- Control Group: Patients who have not experienced lymphedema but require surgery due to other diseases such as cancer, trauma, chronic wounds, skin defects, etc.
- Experimental Group: Patients who have lymphedema and undergone lymphedema surgery.
You may not qualify if:
- \. Individuals with venous thrombosis, chronic heart failure, and renal failure.
- \. Vulnerable populations, individuals with limited mobility, pregnant women, and minors.
- \. Those expected to be unable to attend follow-up visits or complete the study smoothly.
- \. Participants who express doubts about the trial and cannot provide satisfactory answers.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, 83301, Taiwan
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 16, 2024
First Posted
February 2, 2024
Study Start
September 20, 2023
Primary Completion
September 20, 2024
Study Completion
January 12, 2026
Last Updated
February 2, 2024
Record last verified: 2023-09