TAPSE/PASP Anesthesia

NCT06237543 | Unknown

• 1 other identifier: 2024-2
• Study Type: observational
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

TAPSE, one of the methods for evaluating right ventricular systolic function; It is a bar parameter that can easily measure apex-basal shortening and provides specific information about global RV function. TAPSE/PASP can be calculated as load-independent parameters to evaluate RV function. Because RV function is sensitive to change in afterload, known as the RV-pulmonary circulation (PC) connection. This study aims to identify patients who are candidates for hypotensive events due to general anesthesia in a hemodynamically stable population.

Conditions

Hypotension

Keywords

TAPSE; PASP; HYPOTENSİON; PULMONER RESECTİON

Outcome Measures

Primary Outcomes (1)

• echocardiography

  TAPSE/ PASP (mm/mmHg)

  30 minute

Secondary Outcomes (1)

• tension

  4-5 hours

Study Arms (2)

Hypotension

Patients with a 30% decrease in SBP from baseline and a decrease in MAP below 65 mmHg in the first 10 minutes after anesthesia induction will be considered to have hypotension.

Other: hypotension

none hypotension

Patients who do not have a 30% decrease from the baseline in SBP and a decrease in MAP below 65 mmHg in the first 10 minutes after anesthesia induction will be considered as not having hypotension.

Interventions

hypotension OTHER

MAP below 55 mmHg or long-term (2 minutes or more) hypotensive attacks will be treated with ephedrine 0.1mg/kg.

Also known as: treatment

Hypotension

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

ASA1-3 patients aged 18-75 who will undergo pulmonary resection surgery

You may qualify if:

• Written informed consent;
• years old
• ASA Physical Status 1-3;
• Patients planned for pulmonary resection surgery

You may not qualify if:

• The patient is pregnant
• After cardiac surgery
• Severe pulmonary hypertension
• Severe valve disease
• Hypertrophic or dilated cardiomyopathy
• Presence of acute myocardial infarction
• Patients with severe visual or hearing impairment/disability
• ASA physical status IV or V
• Ischemic heart disease, conduction disorder.
• History of long-term use of certain medications (β-blockers, angiotensin converting enzyme inhibitors, analgesics, sedatives or tricyclic antidepressants)

Sponsors & Collaborators

• Aydin Adnan Menderes University: lead

Study Sites (1)

Ferdi Gülaştı

Aydin, 09020, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Hypotension

Interventions

Hypotension, Controlled; Therapeutics

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Anesthesia and Analgesia

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant prof.dr.

Study Record Dates

• First Submitted: January 15, 2024
• First Posted: February 1, 2024
• Study Start: February 1, 2024
• Primary Completion: February 1, 2025
• Study Completion: February 1, 2026
• Last Updated: February 1, 2024

Record last verified: 2024-01

Locations

TU (1)