Comparison Between Blocks or Not in Joint Arthroplasty

NCT06230081 | Active Not Recruiting

• 1 other identifier: BLAST study
• Study Type: interventional
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate the effect on postoperative pain, opioid consumption and function by adding a combination of regional blocks with local anaesthetic before total hip- and knee arthroplasty compared to standard pain management strategies.

Conditions

Osteoarthritis of the Knee or Hip

Outcome Measures

Primary Outcomes (1)

• Difference in Postoperative pain assessed by NRS

  Patient experienced postop pain assessed by NRS (0-10)

  The day of surgery, postop day 1 and 14 days post-surgery

Secondary Outcomes (8)

• Difference in analgesia consumption

  The day of surgery, postop day 1 and 14 days post-surgery

• Time to mobilization

  The day of surgery, postop day 1

• Incidence of postoperative nausea and vomiting

  The day of surgery, postop day 1

• Difference in postoperative pain depending on method of anesthesia

  The day of surgery, postop day 1 and 14 days post-surgery

• urine catheter usage

  1-5 days post-surgery

Study Arms (2)

Block

ACTIVE COMPARATOR

Hip Arthroplasty: Multimodal analgesic therapy + Ultrasound guided PENG block and Iliohypogastric block or LFCN-block. Knee arthroplasty: Multimodal analgesic therapy + Ultrasound guided iPACK block, triple Genicular blocks, Vastus intermedius block, Adductor canal block and AFCN-block.

Drug: Ropivacain 5 mg/ml + Clonidine

No block

NO INTERVENTION

Hip Arthroplasty: Multimodal analgesic therapy Knee Arthroplasty: Multimodal analgesic therapy + LIA

Interventions

Ropivacain 5 mg/ml + Clonidine DRUG

Drug used in the block

Block

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Osteoarthritis of the knee- or hip necessitating total knee- or hip replacement
• Patients who understand the conditions of the study and are willing to participate for the length of the prescribed follow-up

You may not qualify if:

• Known allergy to local anesthetics or other contraindication for the use of local anesthetics.
• Coagulopathy
• Bilateral operation
• Revision arthroplasty

Sponsors & Collaborators

• Region Skane: lead

Study Sites (1)

Dept of Anaesthesiology, Trelleborg Hospital

Trelleborg, Sweden

Location

MeSH Terms

Conditions

Osteoarthritis, Knee

Interventions

Clonidine

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Imidazolines; Imidazoles; Azoles; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds

Study Officials

• Gunnar Flivik, MD PhD

  Department of Orthopedics, Skane Univ Hosp

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Nurses and physiotherapists evaluating the patients are blinded as well as the physician compiling the data
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The patients are randomized to either block or no block therapy

Study Record Dates

• First Submitted: January 4, 2024
• First Posted: January 30, 2024
• Study Start: February 1, 2024
• Primary Completion: March 30, 2025
• Study Completion: April 26, 2026
• Last Updated: April 28, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)