Increased Blood Glucose Levels After Steroid Injection

NCT06228911 | Completed

• 1 other identifier: GH; 5615
• Study Type: interventional
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

a sample of 600 patients diagnosed as Knee osteoarthritis injected with 40 mg triamcinolone, recorded their morning fasting blood glucose levels for 7 days before injection used as the baseline blood glucose level, which was compared with FBS levels for 14 days after steroid injection. Our study compared the differences in blood glucose changes between HbA1c \>7% and HbA1c ≤7% groups and those between insulin and non-insulin treated groups.

Conditions

Osteoarthritis, Knee; Diabete Type 2

Outcome Measures

Primary Outcomes (2)

• high blood glucose

  glucose increases after steroid dose

  3 years

• low blood glucose

  glucose decreases after steroid dose

  3 years

Study Arms (2)

insulin treated group

EXPERIMENTAL

Drug: steroid (triamcinolone)

non-insulin treated groups

EXPERIMENTAL

Drug: steroid (triamcinolone)

Interventions

steroid (triamcinolone) DRUG

triamcinolone is a synthetic corticosteroid medication used topically to treat various skin conditions, to relieve the discomfort of mouth sores, and by injection into joints to treat various joint conditions

insulin treated group; non-insulin treated groups

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age \> 18 years, patients with knee osteoarthritis diagnosed according to American College of Rheumatology (ACR) Criteria (17), and grade1-3 in Kallgren-Laurence radiographic scale (18), whom failed to response to medical treatment including paracetamol and nonsteroidal anti-inflammatory medication, and to physical therapy, checking their blood glucose values daily.

You may not qualify if:

• Patients who were unable to provide consent, patients had any contraindications to corticosteroids, patients who had received oral corticosteroid in the past 6 months or corticosteroid injection in the previous 3 months, patients who had no monitoring HbA1c level before injection or also whom had not monitor blood glucose levels before or after injection.

Sponsors & Collaborators

• Syrian Private University: lead

Study Sites (1)

Faculty of Medicine, Damascus University, Syria

Damascus, 1, Syria

Location

MeSH Terms

Conditions

Osteoarthritis, Knee; Diabetes Mellitus, Type 2

Interventions

Steroids; Triamcinolone

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Fused-Ring Compounds; Polycyclic Compounds; Pregnadienes; Pregnanes; Steroids, Fluorinated

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor Diaa Haj Ali

Study Record Dates

• First Submitted: January 18, 2024
• First Posted: January 29, 2024
• Study Start: January 15, 2020
• Primary Completion: September 15, 2023
• Study Completion: September 15, 2023
• Last Updated: January 30, 2024

Record last verified: 2024-01

Locations

SY (1)