Effects of Corrective Exercise Training for Improving Neuropathic Pain and Function in Knee Osteoarthritis

NCT04995250 | Completed DMC

• 1 other identifier: REC/Lhr/1065
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with neuropathic pain had longer duration of symptoms increased severity of pain, functional limitation and disability as compare to the patient with general knee osteoarthritis. Objective: To find out the effects of corrective exercise training for improving neuropathic pain and function in knee OA patients.

Conditions

Osteoarthritis, Knee

Keywords

Knee osteoarthritis

Outcome Measures

Primary Outcomes (3)

• Western Ontario and McMaster Osteoarthritis Index

  0-100, 0 means no disability 100 means maximum disability

  6 months

• Numeric pain rating scale

  0-10,no pain and the worse pain, on an 11 point scale

  6 months

• Douleur Neuropathique 4 Questionnaire

  The total score is calculated as the sum of 10 items and the cut off value for the diagnosis of neuropathic pain is a total score of 4/10

  6 months

Study Arms (1)

Corrective exercise training for knee Osteoarthritis

EXPERIMENTAL

Other: corrective exercise training for knee

Interventions

corrective exercise training for knee OTHER

All patients received 12 weeks (3 days per week) physiotherapy sessions with hot pack, TENS and Ultrasound session for 10 mints and knee isometric, quad strengthening, adductor and abductor strengthening, calf stretch, hamstring stretch, Maitland mobilization, Unconventional Corrective knee exercise protocol treatment: standing on one extremity, up and down on bosu exercise, walking to lateral direction, walking to anterio-posterior direction, walking to anterio-posterior and lateral for 20 mints. Data were collected at baseline, at week 4 and at post treatment (week 12).

Corrective exercise training for knee Osteoarthritis

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• ACR Criteria for osteoarthritis
• Neuropathic pain
• Age over 65
• DN4 cut off value is 4/10
• Less than 30 minutes of morning stiffness
• Grade I and II
• Crepitus on active motion
• Bony tenderness
• Bony enlargement
• No palpable warmth of synovium

You may not qualify if:

• Knee complain that require urgent medical attention (fracture and infection)
• Diabetes mellitus
• Patients with malignancies
• Neurological disorders
• Systematic musculoskeletal diseases (Parkinson's, rheumatoid arthritis etc)
• Incapability of understanding implication of participants

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Riphah Rehabilitation Center

Lahore, Punjab Province, 54000, Pakistan

Location

Related Publications (6)

• Polat CS, Dogan A, Sezgin Ozcan D, Koseoglu BF, Kocer Akselim S. Is There a Possible Neuropathic Pain Component in Knee Osteoarthritis? Arch Rheumatol. 2017 Apr 24;32(4):333-338. doi: 10.5606/ArchRheumatol.2017.6006. eCollection 2017 Dec.

  PMID: 29901006 BACKGROUND

• Nelson AE, Allen KD, Golightly YM, Goode AP, Jordan JM. A systematic review of recommendations and guidelines for the management of osteoarthritis: The chronic osteoarthritis management initiative of the U.S. bone and joint initiative. Semin Arthritis Rheum. 2014 Jun;43(6):701-12. doi: 10.1016/j.semarthrit.2013.11.012. Epub 2013 Dec 4.

  PMID: 24387819 BACKGROUND

• Knoop J, Steultjens MP, van der Leeden M, van der Esch M, Thorstensson CA, Roorda LD, Lems WF, Dekker J. Proprioception in knee osteoarthritis: a narrative review. Osteoarthritis Cartilage. 2011 Apr;19(4):381-8. doi: 10.1016/j.joca.2011.01.003. Epub 2011 Jan 18.

  PMID: 21251988 BACKGROUND

• Takacs J, Carpenter MG, Garland SJ, Hunt MA. The role of neuromuscular changes in aging and knee osteoarthritis on dynamic postural control. Aging Dis. 2013 Jan 15;4(2):84-99. Print 2013 Apr.

  PMID: 23696951 BACKGROUND

• Beckwee D, Vaes P, Cnudde M, Swinnen E, Bautmans I. Osteoarthritis of the knee: why does exercise work? A qualitative study of the literature. Ageing Res Rev. 2013 Jan;12(1):226-36. doi: 10.1016/j.arr.2012.09.005. Epub 2012 Sep 28.

  PMID: 23026409 BACKGROUND

• Sazo-Rodriguez S, Mendez-Rebolledo G, Guzman-Munoz E, Rubio-Palma P. The effects of progressive neuromuscular training on postural balance and functionality in elderly patients with knee osteoarthritis: a pilot study. J Phys Ther Sci. 2017 Jul;29(7):1229-1235. doi: 10.1589/jpts.29.1229. Epub 2017 Jul 15.

  PMID: 28744054 BACKGROUND

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Maryam Shabbir, MS

  Riphah International University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 26, 2021
• First Posted: August 6, 2021
• Study Start: April 1, 2020
• Primary Completion: November 30, 2020
• Study Completion: December 30, 2020
• Last Updated: September 2, 2021

Record last verified: 2021-08

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)