Neural Mechanisms of Music Intervention Chronic Arm Hemiparesis Following Stroke: A Single Case Series EEG Study

NCT06223529 | Recruiting

• 1 other identifier: MusiStroke
• Study Type: interventional
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

The aims of the study are to recruit five participants with stroke upper limb hemiparesis and determine the effects on neural reorganisation of a three-week music intervention using electroencephalogram measures. Secondly, the researchers will measure for changes in arm function before and after the three-week music intervention. This is a single-arm pre-/post experiment Primary research questions: What are the neuroplastic changes induced by Therapeutic Instrumental Music Performance (TIMP)? Secondary research questions What are the functional changes in hemiparetic arm and hand induced by TIMP? Participants will be recruited once they have completed their statutory community stroke rehabilitation. They will receive 15 X music therapy sessions in their home over three-weeks. Exercises will be delivered by trained clinicians, including music therapists and stroke rehabilitations specialists. Exercises will be facilitated for full range of arm movement, using a range of percussion instruments on stands and handheld, and iPad with touchscreen instruments, which include keyboards and string instruments that can be played using pinch-grip, holding a stylus/plectrum. Pre-/post intervention period EEG recordings will made. Stroke Specific Quality of Life (SSQoL), Action Research Arm Test and nine-hole-peg-test data will be collected from participants in their homes at weeks: 1, 4, 7 and 10.

Conditions

Stroke; Hemiparesis; Home-based

Keywords

Neurologic Music Therapy; electroencephalography

Outcome Measures

Primary Outcomes (1)

• Electroencephalogram (EEG): Power in EEG Alpha and Beta frequency bands

  Power in EEG Alpha and Beta frequency bands (event-related synchronization and de-synchronization) during simple motor tasks

  baseline: pre-intervention, immediately after the intervention

Secondary Outcomes (4)

• Electroencephalogram (EEG): Amplitude of P3 event-related potential

  baseline: pre-intervention, immediately after the intervention

• Electroencephalogram (EEG): Frontal Alpha Asymmetry

  baseline: pre-intervention, immediately after the intervention

• Action Research Arm Test (ARAT)

  Baseline, pre-intervention (week 4), post-intervention (week 7), follow-up (week 10)

• Nine hole peg test

  Baseline (week 1), pre-intervention (week 4), post-intervention (week 7), Follow-up (week 10)

Other Outcomes (1)

• Stroke Specific Quality of Life Questionnaire

  Baseline (week 1), pre-intervention (week 4), post-intervention (week 7), follow-up (week 10)

Study Arms (1)

Music intervention

EXPERIMENTAL

Music-based exercises for arm/hand coordination, range of movement and dexterity using a selection of hand percussion, stand-mounted percussion and tablet with touchscreen instruments.

Behavioral: Therapeutic Instrumental Music Performance

Interventions

Therapeutic Instrumental Music Performance BEHAVIORAL

Exercises using musical instruments to improve hemiparetic hand and arm function

Music intervention

Eligibility Criteria

• Age: 18 Years - 110 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged 18+
• Ischemic stroke
• Three weeks to 60 months post-stroke
• to 49/57 Action Research Arm Test (ARAT) score \*
• Able to follow instructions and consent
• Right-hand dominant

You may not qualify if:

• Hemorrhagic stroke
• No movement in arm
• Unable to consent to participate
• Currently receiving music therapy
• Left-hand dominant
• Ambidextrous
• Not registered with a GP. We will require GP details to inform them in case of any incidental findings in the EEG.

Sponsors & Collaborators

• Anglia Ruskin University: lead
• Cambridgeshire Community Services NHS Trust: collaborator

Study Sites (1)

Cambridgeshire COmmunity Services NHS Trust

Bedford, Bedfordshire, United Kingdom

RECRUITING

Related Publications (2)

• Altenmuller E, Marco-Pallares J, Munte TF, Schneider S. Neural reorganization underlies improvement in stroke-induced motor dysfunction by music-supported therapy. Ann N Y Acad Sci. 2009 Jul;1169:395-405. doi: 10.1111/j.1749-6632.2009.04580.x.

  PMID: 19673814 BACKGROUND

• Fachner JC, Maidhof C, Grocke D, Nygaard Pedersen I, Trondalen G, Tucek G, Bonde LO. "Telling me not to worry..." Hyperscanning and Neural Dynamics of Emotion Processing During Guided Imagery and Music. Front Psychol. 2019 Jul 25;10:1561. doi: 10.3389/fpsyg.2019.01561. eCollection 2019.

  PMID: 31402880 RESULT

MeSH Terms

Conditions

Stroke; Paresis

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Alexander J Street, PhD

  Anglia Ruskin University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Alexander J Street, PhD

CONTACT

07799392838; alex.street@anglia.ac.uk

Clemens Maidhof, PhD

CONTACT

clemens.maidhof@aru.ac.uk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: The person collecting data on quality of life and arm function in participants' homes will be blinded to whether pre- or post intervention
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Research Fellow (Music therapy)

Model Details: Single case series pre-/post EEG with repeated upper limb measures

Study Record Dates

• First Submitted: October 3, 2023
• First Posted: January 25, 2024
• Study Start: July 1, 2024
• Primary Completion: February 28, 2025
• Study Completion: May 1, 2025
• Last Updated: July 31, 2024

Record last verified: 2024-07

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)