Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke

NCT06598150 | Recruiting

• 2 other identifiers: STU002148551R03HD113915-01
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

This study uses functional magnetic resonance imaging to map neural activity throughout the central nervous system during a shoulder abduction task to characterize what motor pathways are being used post-stroke.

Conditions

Stroke; Hemiparesis

Keywords

functional magnetic resonance imaging

Outcome Measures

Primary Outcomes (1)

• BOLD activation

  BOLD fMRI data will be analyzed to map neural activation associated with the shoulder abduction task.

  3 days to 3 months

Study Arms (1)

Shoulder Abduction

EXPERIMENTAL

Other: Shoulder Abduction

Interventions

Shoulder Abduction OTHER

Individuals will be visually cued to perform short, unilateral, isometric shoulder abduction tasks. A visual display will provide real-time feedback of the shoulder abduction torque, to help the participant target a predetermined torque level.

Shoulder Abduction

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged at least 18y
• Able to perform shoulder abduction task (confirmed during screening and initial examination)
• Safe to undergo MRI
• Able to follow visual instructions using MRI-compatible vision correction goggles
• No brainstem or cerebellar lesions
• No severe concurrent medical problems
• Cognitive/attentional capacity to focus on a task
• Able to communicate in English or Spanish
• Have sustained only one unilateral subcortical, ischemic lesion in the territory supplied by the Middle Cerebral Artery (confirmed by clinical or radiological reports) at least one year prior to participation in this project
• Paresis confined to one side, with moderate-to-severe motor impairment of the upper limb (Upper Extremity Fugl-Meyer score between 10 and 45).

You may not qualify if:

• MRI contraindications
• Severe claustrophobia
• Pregnant women
• Prisoners
• Vulnerable populations
• Diagnosis/history of:
• multiple sclerosis
• brain tumor
• brain radiation
• traumatic brain injury
• dementia
• Parkinson's disease
• Concurrent enrollment in an intervention study
• Concurrent use of medications known to suppress central nervous system activity

Sponsors & Collaborators

• Northwestern University: lead
• Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): collaborator

Study Sites (1)

Northwestern University

Chicago, Illinois, 60611, United States

RECRUITING

MeSH Terms

Conditions

Stroke; Paresis

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Molly G Bright, DPhil

  Northwestern University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Michelle Medina, BS

CONTACT

872-272-7687; anvil@northwestern.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: September 12, 2024
• First Posted: September 19, 2024
• Study Start: May 20, 2023
• Primary Completion (Estimated): August 31, 2026
• Study Completion (Estimated): August 31, 2026
• Last Updated: October 1, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: ANALYTIC CODE
• Time Frame: At time of publication (or at project completion, whichever occurs first).
• Access Criteria: Data will be anonymized and made publicly available, and at that time no approval is needed and therefore there are no access criteria.

Locations

US (1)