Radiomics Analysis Based on MRI to Detect Brucella Spondylitis

NCT06220500 | Unknown

• 1 other identifier: AHInnerMongolia-BS
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Brucella spondylitis, an infectious spinal disease caused by the invasion of Brucella bacteria into the body. Its diagnosis relies mainly on laboratory and imaging tests. Due to the limited diagnostic ability of X-ray and CT for Brucella spondylitis, MRI has become the main diagnostic tool. In recent years, functional magnetic resonance technology has demonstrated great advantages in the diagnosis and therapeutic evaluation of brucellosis spondylitis, which can provide pathophysiologic information about the disease and is also a noninvasive and noninvasive diagnostic tool with a broader application prospect. Radiomics, an emerging approach, has also shown better diagnostic efficacy for this disease.

Conditions

Brucella Spondylitis

Keywords

Radiomics; MRI

Outcome Measures

Primary Outcomes (1)

• The useful value of radiomics of MRI in BS clinical diagnosis.

  The investigators will validate the results. The validation and external test cohorts will be used to evaluate the performance of the prediction models. The micro-avg and macro-avg precision, true positive (TP), true negative (TN), false positive (FP), false negative (FN), accuracy, sensitivity, specificity, and F1 score of different models will be calculated. Receiver operating characteristic (ROC) curves is going to be used to assess the sensitivity and specificity of the models, and the area under the ROC curve (AUC) was used to describe the discriminative power of the models. The investigators think radiomics of MRI can provide a reliable basis for early damage in brucellosis spondylitis and provides evidence for early clinical intervention.

  December 2024

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

About 100 patients with Brucellosis including patients with brucella spondylitis obviously and patients with obvious waist pain and the conventional MRI showed abnormalities were selected.

You may qualify if:

• Outpatients/Inpatients
• Age 18-70 years
• Meet diagnostic criteria for brucellosis
• Meet symptoms of brucellosis spondylitis
• Voluntarily sign an informed consent form
• Can cooperate with MRI examination

You may not qualify if:

• Patients with serious diseases of other systems
• History of malignant tumors of the vertebral body
• History of tuberculosis
• Contraindications to magnetic resonance imaging

Sponsors & Collaborators

• The Affiliated Hospital of Inner Mongolia Medical University: lead

Study Sites (1)

Affiliated Hospital of Inner Mongolia Medical University

Hohhot, Inner Mongolia, China

RECRUITING

Study Officials

• Peng fei Qiao, MD

  The Affiliated Hospital of Inner Mongolia Medical University

  STUDY DIRECTOR

Central Study Contacts

Peng fei Qiao, MD

CONTACT

15904718239; 24853170@qq.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 11, 2024
• First Posted: January 24, 2024
• Study Start: January 1, 2023
• Primary Completion: August 1, 2024
• Study Completion: December 1, 2024
• Last Updated: January 24, 2024

Record last verified: 2024-01

Locations

CN (1)