NCT06218576|Completed
Sensitivity Comparison of Follow-up MRI Between Acute Cerebral and Cerebellar Cortical Microinfarctions ( CMI )Microinfarctions
CMI
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CMI
Sponsor study identifier
observational
59
1 country
1
Study Start
February 15, 2024
Actual (reported)Primary Completion
July 1, 2024
Actual (reported)Study Completion
July 1, 2024
Actual (reported)Cerebral cortical microinfarctions (CMI) are frequently observed on MRI and histology studies, especially in elderly patients and in patients with cognitive dysfunction. The majority of these studies analysed chronic cerebral CMI lesions. The few studies reporting on temporal dynamics of MRI signal of acute cerebral CMI showed very low sensibility for persisting signal changes on follow-up MRI on standard MRI sequences. A retrospective study, analysing follow-up 3T MRI in 25 patients with acute cerebral CMI (defined as ≤10 mm on DWI), showed a chronic cerebral CMI detection rate of only 16% on T2-weighted and 5% on FLAIR imaging after a mean follow-up period of 33 months (with a very wide range of 0.5-142 months). Another 3T MRI study including seven patients showed disappearance of all acute cerebral very small-sized CMI (defined as \<5 mm size on initial DWI) on all follow-up MRI sequences (T1- and T2-weighted and FLAIR imaging, performed after one month). Recently, it has been shown that chronic relatively small (\<20 mm) cerebellar cortical infarctions (based on diffusion-weighted imaging) were frequently observed in acute stroke patients, especially in case of cardioembolic stroke (with chronic small cerebellar cortical infarctions observed in 32% of cases). The high prevalence of these chronic small cerebellar cortical infarctions suggest a possible higher detection rate of chronic small-sized infarction in the cerebellum compared to the supratentorial brain.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 1, 2024
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 12, 2024
Actual (reported)January 23, 2024
Actual (reported)February 15, 2024
Actual (reported)July 1, 2024
Actual (reported)July 1, 2024
Actual (reported)Chronic CMI
Detection rate of chronic CMI on follow-up MRI used in daily clinical practice after initial acute cerebral and cerebellar CMI (≤10 mm) (Nb)
6 monthes
CMI localisations
Compare initial acute cerebral and cerebellar CMI (≤10 mm) localisation (cerebral or cerebellar)
6 monthes
Patients with acute cerebral and/or cerebellar CMI
None, purely observational study
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Patient admitted to Nîmes University Hospital between February 2021 and June 2023 with initial MRI performed within one week after symptom onset, symptomatic brain infarction confirmed by DWI, and the presence of acute cerebral and/or cerebellar CMI
CHU de Nîmes
Nîmes, 30029, France
Renard D, Serghine Y, Collemiche FL, Parayre A, Wacongne A, Parvu T, Laurent-Chabalier S. Detection of chronic cerebellar and cerebral very small cortical infarctions on T2 and FLAIR 1.5T MRI. Acta Neurol Belg. 2026 Apr;126(2):601-609. doi: 10.1007/s13760-026-03003-1. Epub 2026 Feb 14.
Anissa MEGZARI
Centre Hospitalier Universitaire de Nīmes
59 participants (actual enrollment reported by the registry).
First Submitted
January 12, 2024
First Posted
January 23, 2024
Study Start
February 15, 2024
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
July 1, 2024
Actual (reported)Study Completion
July 1, 2024
Actual (reported)Last Updated
June 17, 2026
Record last verified: 2026-06
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Source: ClinicalTrials.gov.
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