Study of Cerebral Activation by fNIRS During Vibration-induced Illusion of Movement in Healthy and Stroke Participants.

NCT06218563 | Completed

• 1 other identifier: CHRO-2023-05
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the cerebral activation of healthy and stroke participants in 4 or 2 different conditions (repeated 2 times) of vibration-induced illusion of movement respectively, resulting in 8 or 4 vibration blocks with 3 vibrations per block. The frequency of the vibration being 80 Hz. Healthy participants:

• Right arm, eyes opened
• Right arm, eyes closed
• Left arm, eyes opened
• Left arm, eyes closed Stroke participants:
• Deficient side, eyes opened
• Deficient side, eyes closed The aim is to compare the subjective sensation of movement score and cerebral activations of healthy/stroke participants depending on the condition.

Conditions

Healthy; Stroke, Acute

Keywords

Vibration; Illusion of movement; Functional Near Infrared Spectroscopy

Outcome Measures

Primary Outcomes (2)

• Mean change in the concentration of oxyhemoglobin during the task

  The HbO2 signals are considered as indicators of the hemodynamic response.

  Day 0

• Mean change in the concentration of deoxyhemoglobin during the task

  The HbR signals are considered as indicators of the hemodynamic response.

  Day 0

Secondary Outcomes (1)

• SKIP scale

  Day 0

Study Arms (1)

vibration-induced illusion of movement

EXPERIMENTAL

The protocol consists of 4 or 2 different conditions (repeated 2 times) of vibration-induced illusion of movement in healthy and stroke participants respectively, resulting in 8 or 4 vibration blocks with 3 vibrations per block: Healthy participants, 2 times each (24 vibrations): * Right arm, eyes opened (no-illusion condition; RO) * Right arm, eyes closed (illusion condition; RC) * Left arm, eyes opened (no-illusion condition; LO) * Left arm, eyes closed (illusion condition; LC) Stroke participants, 2 times each (12 vibrations): * Deficient side, eyes opened (no-illusion condition; DO) * Deficient side, eyes closed (illusion condition; DC)

Other: vibration-induced illusion of movement

Interventions

vibration-induced illusion of movement OTHER

Conditions order is pseudorandomized, participants can start by the left or the right arm with eyes opened or closed. When starting with either the left or right arm, all conditions are completed before moving on to the other arm (for healthy participants). In total, the number of participants starting with right or left vibration should be the same.

vibration-induced illusion of movement

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years old
• Able to sign a consent form
• Sufficient command of the French language to understand instructions
• Affiliated to a social security scheme
• Healthy participants:
• Right handed
• No neurological disease or motor deficit
• Stroke participants:
• Stroke volunteers in acute phase (before day 14 post-stroke)
• Not aphasic
• Able to maintain sitting position without difficulty
• Deficit moteur
• Able to sign a consent form

You may not qualify if:

• Person under tutorship or curatorship
• Known allergy to of the fNIRS cap components: neoprene
• No vibrations feeling on the deficient side
• Vigilance-modifying drugs (high-dose psychotropics, antispastic drugs)

Sponsors & Collaborators

• Centre Hospitalier Régional d'Orléans: lead

Study Sites (1)

CHU d'ORLEANS

Orléans, 45067, France

Location

Related Publications (14)

• Adamo DE, Scotland S, Martin BJ. Upper limb kinesthetic asymmetries: gender and handedness effects. Neurosci Lett. 2012 May 16;516(2):188-92. doi: 10.1016/j.neulet.2012.03.077. Epub 2012 Apr 3.

  PMID: 22490887 BACKGROUND

• Chancel M, Landelle C, Blanchard C, Felician O, Guerraz M, Kavounoudias A. Hand movement illusions show changes in sensory reliance and preservation of multisensory integration with age for kinaesthesia. Neuropsychologia. 2018 Oct;119:45-58. doi: 10.1016/j.neuropsychologia.2018.07.027. Epub 2018 Jul 29.

  PMID: 30063911 BACKGROUND

• Collins DF, Refshauge KM, Todd G, Gandevia SC. Cutaneous receptors contribute to kinesthesia at the index finger, elbow, and knee. J Neurophysiol. 2005 Sep;94(3):1699-706. doi: 10.1152/jn.00191.2005. Epub 2005 May 25.

  PMID: 15917323 BACKGROUND

• Desmurget M, Reilly KT, Richard N, Szathmari A, Mottolese C, Sirigu A. Movement intention after parietal cortex stimulation in humans. Science. 2009 May 8;324(5928):811-3. doi: 10.1126/science.1169896.

  PMID: 19423830 BACKGROUND

• Gilhodes JC, Roll JP, Tardy-Gervet MF. Perceptual and motor effects of agonist-antagonist muscle vibration in man. Exp Brain Res. 1986;61(2):395-402. doi: 10.1007/BF00239528.

  PMID: 3948946 BACKGROUND

• Guerraz M, Provost S, Narison R, Brugnon A, Virolle S, Bresciani JP. Integration of visual and proprioceptive afferents in kinesthesia. Neuroscience. 2012 Oct 25;223:258-68. doi: 10.1016/j.neuroscience.2012.07.059. Epub 2012 Aug 3.

  PMID: 22864182 BACKGROUND

• Hagura N, Takei T, Hirose S, Aramaki Y, Matsumura M, Sadato N, Naito E. Activity in the posterior parietal cortex mediates visual dominance over kinesthesia. J Neurosci. 2007 Jun 27;27(26):7047-53. doi: 10.1523/JNEUROSCI.0970-07.2007.

  PMID: 17596454 BACKGROUND

• Imai R, Hayashida K, Nakano H, Morioka S. Brain Activity Associated with the Illusion of Motion Evoked by Different Vibration Stimulation Devices: An fNIRS Study. J Phys Ther Sci. 2014 Jul;26(7):1115-9. doi: 10.1589/jpts.26.1115. Epub 2014 Jul 30.

  PMID: 25140108 BACKGROUND

• Kodama T, Nakano H, Ohsugi H, Murata S. Effects of vibratory stimulation-induced kinesthetic illusions on the neural activities of patients with stroke. J Phys Ther Sci. 2016 Jan;28(2):419-25. doi: 10.1589/jpts.28.419. Epub 2016 Feb 29.

  PMID: 27065525 BACKGROUND

• Proske U, Gandevia SC. The proprioceptive senses: their roles in signaling body shape, body position and movement, and muscle force. Physiol Rev. 2012 Oct;92(4):1651-97. doi: 10.1152/physrev.00048.2011.

  PMID: 23073629 BACKGROUND

• Romaiguere P, Anton JL, Roth M, Casini L, Roll JP. Motor and parietal cortical areas both underlie kinaesthesia. Brain Res Cogn Brain Res. 2003 Mar;16(1):74-82. doi: 10.1016/s0926-6410(02)00221-5.

  PMID: 12589891 BACKGROUND

• Skinner HB, Barrack RL, Cook SD. Age-related decline in proprioception. Clin Orthop Relat Res. 1984 Apr;(184):208-11.

  PMID: 6705349 BACKGROUND

• Tidoni E, Fusco G, Leonardis D, Frisoli A, Bergamasco M, Aglioti SM. Illusory movements induced by tendon vibration in right- and left-handed people. Exp Brain Res. 2015 Feb;233(2):375-83. doi: 10.1007/s00221-014-4121-8. Epub 2014 Oct 8.

  PMID: 25294499 BACKGROUND

• Leger B, Auzou P, Fourdrinoy E, Sarrazin M, Celot S, Gay C, de Dieuleveult B, Cohen C, Perrey S, Ozsancak C. Vibration-induced illusion of movement is hindered by acute stroke but mostly by aging: a cross-sectional study. Aging Clin Exp Res. 2025 Dec 1;38(1):20. doi: 10.1007/s40520-025-03247-6.

  PMID: 41324779 DERIVED

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Canan OZSANCAK, Dr

  CHU d'Orléans

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The protocol consists of 4 or 2 different conditions (repeated 2 times) of vibration-induced illusion of movement in healthy and stroke participants respectively, resulting in 8 or 4 vibration blocks with 3 vibrations per block. Conditions order is pseudorandomized, participants can start by the left or the right arm with eyes opened or closed. When starting with either the left or right arm, all conditions are completed before moving on to the other arm (for healthy participants). In total, the number of participants starting with right or left vibration should be the same.

Study Record Dates

• First Submitted: January 12, 2024
• First Posted: January 23, 2024
• Study Start: January 10, 2024
• Primary Completion: June 25, 2025
• Study Completion: June 25, 2025
• Last Updated: July 8, 2025

Record last verified: 2025-07

Locations

FR (1)