Comparing the Effects of Different Types of Exercise on Glucose Handling

NCT06217679 | Completed

• 1 other identifier: ORE #22477
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the proposed study is to compare the acute effects of different types of exercise modalities on glucose handling in young, healthy males and females. The exercise modalities that will be compared include: a high intensity interval exercise (HIIE) protocol, a moderate intensity continuous exercise (MICE) protocol and a low-load, high-repetition (LL-HR) resistance exercise protocol.

Conditions

Glycemic Control; Insulin Sensitivity; Sex Differences

Outcome Measures

Primary Outcomes (4)

• Blood insulin change

  To assess the effect of sex and exercise on basal and post-exercise blood insulin

  120mins

• Blood glucose change

  To assess the effect of sex and exercise on basal and post-exercise blood glucose.

  120mins

• Blood c-peptide change

  To assess the effect of sex and exercise on basal and post-exercise blood c-peptide.

  120mins

• Insulin sensitivity change

  Assess the changes in insulin sensitivity pre to post exercise

  120mins

Secondary Outcomes (7)

• TBC1 domain family member 4 change (TBC1D4)

  35mins

• TBC1 domain family member 1 change (TBC1D1)

  35mins

• protein kinase B change

  35mins

• 5' adenosine monophosphate-activated protein kinase change

  35mins

• glucose transporter 4 change (GLUT4)

  35mins

Study Arms (4)

Control Oral Glucose Tolerance Test

EXPERIMENTAL

This visit will include a baseline OGTT to be used as a pre-exercise baseline measure for each of the arms. Participants will then consume a 75g glucose beverage (Trutol, Thermo Scientific) and blood samples will be drawn at 0, 10, 20, 30, 45, 60, 75, 90 and 120 minutes post consumption.

Other: Control Oral Glucose Tolerance Test; Other: Mixed Exercise

High intensity interval exercise (HIIE)

EXPERIMENTAL

Participants performed a High intensity interval exercise (HIIE) bout which includes 10 x 1 min at 90% maximum heart rate (HRmax) with 5 min warm up and 5 min cool down at 50watts (low state steady cycling). 90mins following the exercise bout participants will undergo another oral glucose tolerance test.

Other: Control Oral Glucose Tolerance Test; Other: Mixed Exercise

Moderate intensity continuous exercise (MICE)

EXPERIMENTAL

Participants performed a Moderate intensity continuous exercise (MICE) bout which includes 30 min at 65% maximal aerobic capacity (VO2max). 90mins following the exercise bout participants will undergo another oral glucose tolerance test.

Other: Control Oral Glucose Tolerance Test; Other: Mixed Exercise

Low-load, high-repetition resistance exercise (LL-HR)

EXPERIMENTAL

Participants performed a Low-load, high-rep resistance exercise (LL-HR) bout which includes a whole body resistance exercise bout, 3 sets at 30% maximum strength (1RM) for leg press, knee extension, hamstring curl, lat pulldown, shoulder press, chest press, 20-25 reps, last set to failure. 90mins following the exercise bout participants will undergo another oral glucose tolerance test.

Other: Control Oral Glucose Tolerance Test; Other: Mixed Exercise

Interventions

Control Oral Glucose Tolerance Test OTHER

control oral glucose tolerance test

Control Oral Glucose Tolerance Test; High intensity interval exercise (HIIE); Low-load, high-repetition resistance exercise (LL-HR); Moderate intensity continuous exercise (MICE)

Mixed Exercise OTHER

exercise performed in randomized order

Control Oral Glucose Tolerance Test; High intensity interval exercise (HIIE); Low-load, high-repetition resistance exercise (LL-HR); Moderate intensity continuous exercise (MICE)

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• In order to participate in this study, participants must be a healthy man or woman between the ages of 18 and 30 years.

You may not qualify if:

• Presence of chronic health condition(s) \[i.e. metabolic (i.e. Type 1 or type 2 diabetes), cardiovascular (i.e hypertension), respiratory (i.e. chronic pulmonary obstructive disorder) or digestive (i.e. ulcerative colitis) disorders.
• Are pregnant, or suspect that they may be pregnant, or nursing
• Inability to complete the single exercise sessions.
• Regularly participate in cardiovascular (\>3 sessions/week) or resistance training (\>2 sessions/week) exercise.
• Have an allergy to local anesthetic (or family history of allergy)
• Have undergone a barium swallow or an infusion of a contrast agent in the past 3 weeks
• Are taking prescription anti-coagulant or anti-platelet medications (e.g., warfarin, heparin, clopidogrel)
• Inability to exercise as suggested by the get active questionnaire (GAQ)
• BMI \> 27 kg/m2

Sponsors & Collaborators

• University of Waterloo: lead

Study Sites (1)

University of Waterloo

Waterloo, Ontario, N2L 3G1, Canada

Location

Related Publications (1)

• Beaudry KM, Surdi JC, Pancevski K, Tremblay C, Devries MC. Greater glycemic control following low-load, high-repetition resistance exercise compared with moderate-intensity continuous exercise in males and females: a randomized control trial. Appl Physiol Nutr Metab. 2024 Jul 1;49(7):943-955. doi: 10.1139/apnm-2023-0353. Epub 2024 Mar 22.

  PMID: 38518263 DERIVED

MeSH Terms

Conditions

Insulin Resistance

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 8, 2024
• First Posted: January 22, 2024
• Study Start: May 1, 2018
• Primary Completion: October 31, 2019
• Study Completion: October 31, 2019
• Last Updated: February 6, 2024

Record last verified: 2024-01

Locations

CA (1)