Comparative Analysis of Biomarkers in Response to Acute Moderate-Intensity Activity

NCT06217068 | Completed Phase 1

• 1 other identifier: PROJECT00008178
• Study Type: interventional
• Target: 9
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to understand how college students' biomarkers change with a relatively short bout of moderate-intensity physical activity. The investigators are comparing biomarkers in between self-reported physically active and sedentary students in terms of their percent difference and change. The investigators are also studying physically active versus sedentary college students' mental health. This is a mentored student research project in the investigator's lab (not part of a thesis, dissertation, or other coursework requirements), where multiple students have developed research questions using the same study design.

Conditions

Acute Exercise; Aerobic Exercise; Biomarkers

Outcome Measures

Primary Outcomes (5)

• Ammonia

  Blood sample

  Pre-test and post-test (immediately following exercise)

• Insulin

  Blood sample

  Pre-test and post-test (immediately following exercise)

• Cortisol

  Blood sample

  Pre-test and post-test (immediately following exercise)

• C-reactive protein

  Blood sample

  Pre-test and post-test (immediately following exercise)

• Glucose

  Blood sample

  Pre-test and post-test (immediately following exercise)

Study Arms (2)

Sedentary Individuals - Acute Moderate-Intensity Exercise

EXPERIMENTAL

8 minutes of elliptical exercise at a moderate intensity based on heart rate reserve. There will be a 2-minute warm-up and 2-minute cool down period in addition to the 8 minutes at moderate-intensity.

Behavioral: Elliptical Activity

Active Individuals - Acute Moderate-Intensity Exercise

EXPERIMENTAL

8 minutes of elliptical exercise at a moderate intensity based on heart rate reserve. There will be a 2-minute warm-up and 2-minute cool down period in addition to the 8 minutes at moderate-intensity.

Behavioral: Elliptical Activity

Interventions

Elliptical Activity BEHAVIORAL

8 minutes of elliptical exercise at a moderate intensity based on heart rate reserve. There will be a 2-minute warm-up and 2-minute cool down period in addition to the 8 minutes at moderate-intensity.

Active Individuals - Acute Moderate-Intensity Exercise; Sedentary Individuals - Acute Moderate-Intensity Exercise

Eligibility Criteria

• Age: 18 Years - 34 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• This study will enroll full-time students at the investigator's university who are aged 18-34 years.
• Participants will be generally healthy participants, assessed using the 2020 Physical Activity Readiness Questionnaire (first 7 questions) as a screening tool. Individuals who answer "no" to all of the 7 questions will be deemed healthy enough to take part.
• Two balanced groups will be created based on self-reported current activity level, either sedentary (\<30min/week of exercise) or meeting exercise guidelines (\>=150min/week of exercise).
• Potential participants should be willing to complete the blood draws and the 12 minutes of moderate-intensity exercise on an elliptical machine.
• Potential participants should be able to speak and read the English language. This is so they will be able to understand the study protocols clearly.

You may not qualify if:

• Are allergic to nuts because the snacks provided following the blood draw may contain nut products.
• Do not have transportation and parking (if needed) to lab.

Sponsors & Collaborators

• University of Georgia: lead

Study Sites (1)

University of Georgia

Athens, Georgia, 30602, United States

Location

Study Officials

• Jennifer L Gay, PhD

  University of Georgia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Lab processing the blood samples is blinded to participant group.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: Two group pre-test post-test study where groups are determined by current activity level (sedentary versus active). The dose of exercise is being tested between groups to see if there are differential effects of this acute dose at this intensity on biomarkers.

Study Record Dates

• First Submitted: January 10, 2024
• First Posted: January 22, 2024
• Study Start: March 11, 2024
• Primary Completion: February 7, 2025
• Study Completion: February 7, 2025
• Last Updated: February 20, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)