The Burden of Acute Respiratory Failure in Chinese ICUs: a National Cohort Study

NCT06213779 | Completed

• 1 other identifier: Chi-ARDS
• Study Type: observational
• Target: 4,032
• Locations: 1 country
• Sites: 2

Brief Summary

We aim to prospectively assess the burden, management and therapeutic approaches and outcomes of acute respiratory failure requiring respiratory support, during the winter months in China. The purpose of this study is to provide new and current data on the disease burden of acute respiratory failure and ARDS. It will answer the following questions:

• The frequency and disease burden of acute respiratory failure in China;
• The incidence of ARDS based on the new global definition within this patient cohort.
• The mortality of ARDS within this cohort, and how does this vary based on ARDS categories and severity.
• The long-term outcomes (1-year mortality and survivor quality of life) of ARDS within this cohort.
• The nature course of ARDS (different stages and severity of ARDS).
• The respiratory support management strategies, such as recruitment maneuvers, prone positioning, ECCO2R, and ECMO.
• The use of drugs during ICU stays, including glucocorticoid, anticoagulant, nitric oxide, sivelestat, Xuebijing, and ulinastatin.
• The economical burden of acute respiratory failure within this patient cohort.
• The impact of occupation, incomes and education levels on the incidence and mortality of ARDS.

Conditions

Acute Respiratory Failure; Acute Respiratory Distress Syndrome

Outcome Measures

Primary Outcomes (1)

• Development of ARDS with new global definition

  28-days

Secondary Outcomes (1)

• ICU mortality

  28-days

Study Arms (1)

One group

This is a prospective observational study, aimed at collecting an adequate dataset on a large cohort of patients admitted to a large number of ICUs.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Our aim is to obtain a sample of at least 1500 ARDS patients within the cohort of patients receiving respiratory support.

You may qualify if:

• All patients admitted to the participating ICU receiving invasive, non-invasive ventilation or high-flow nasal cannula (HFNC) will be screened and included in the database.

You may not qualify if:

• Age\<18.

Sponsors & Collaborators

• Southeast University, China: lead

Study Sites (2)

China-Japan friendship hospital

Beijin, China

Location

Zhongda Hospital, Southeast university

Nanjing, China

Location

MeSH Terms

Conditions

Respiratory Distress Syndrome

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Respiration Disorders

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 28 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 9, 2024
• First Posted: January 19, 2024
• Study Start: January 1, 2024
• Primary Completion: April 30, 2024
• Study Completion: October 31, 2024
• Last Updated: April 28, 2026

Record last verified: 2026-04

Locations

CN (2)