Cardiovascular Patients With no Standard Modifiable Risk Factors

NCT06199869 | Completed

• 1 other identifier: CVA2024.SMuRFless1
• Study Type: observational
• Target: 5,540
• Locations: 1 country
• Sites: 2

Brief Summary

A growing number of patients develop atherosclerotic cardiovascular disease (ASCVD) despite the absence of standard modifiable risk factors (SMuRF-less). There is scarcity of studies that address this issue in the Middle Eastern population.

Conditions

Cardiovascular Risk Factors

Keywords

Atherosclerotic cardiovascular disease; Standard modifiable risk factors (SMuRFs); Middle Eastern population

Outcome Measures

Primary Outcomes (1)

• Prevalence of patients who do not any of the four SMuRFs

  Group of patients with definite ASCVD who do not have hypertension, diabetes, dyslipidemia or smoking.

  Up to 4 weeks after study enrollment

Interventions

Evaluation of risk factors by direct interview with subjects who have atherosclerotic cardiovascular patients OTHER

Individuals identified with a diagnosis of ASCVD will fill a one page form of the associated risk factors they have

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

1. Adults (18 years of age and older) with ASCVD. 2. ASCVD includes: 1. Coronary heart disease 2. stroke 3. peripheral artery disease.

You may qualify if:

• A diagnosis of atherosclerotic cardiovascular disease (ASCVD).
• Ability to fill the clinical form that evaluates the presence or absence of cardiovascular risk factors including the 4 SMuRFs.

You may not qualify if:

• Atherosclerotic cardiovascular disease diagnosed before the age of 18 years.
• Inability to give detailed history of prespecified risk factors.

Sponsors & Collaborators

• Jordan Collaborating Cardiology Group: lead
• The Jordan Cardiovascular Research Group JoCVRG: collaborator
• Yarmouk University School of Medicine: collaborator

Study Sites (2)

Istishari Hospital

Amman, 11184, Jordan

Location

Yarmouk University School of Medicine

Irbid, Jordan

Location

Related Publications (3)

• Alrida NA, Albikawi Z, Alotaibi N, Alkouri O, Saifan AR, Jarrah M, Hammoudeh A, Khader Y, Alenezy A, Al-Zu'bi BM, Alharbi A, Alhalaiqa F, AbuRuz ME. Association of SMuRFs with cardiovascular risk factors, disease burden, and pharmacological management in Middle Eastern patients with ASCVD and a family history of premature CVD. Front Cardiovasc Med. 2025 Nov 27;12:1678767. doi: 10.3389/fcvm.2025.1678767. eCollection 2025.

  PMID: 41393265 DERIVED

• Alkouri O, Alrida NA, Alabkal RM, Khader Y, Albikawi Z, Ababneh A, Alobaidly A, Qaladi O, Alharbi A, Jarrah M, Alotaibi N, Al-Bashaireh AM, Hammoudeh A, AbuRuz ME, Almustafa LA, Khraisat O, Al-Nsair N. Prevalence of physical activity and its association with atherosclerotic cardiovascular risk factors in young women in the middle east: a sub-analysis of the ANCHORS study. BMC Public Health. 2025 Oct 1;25(1):3268. doi: 10.1186/s12889-025-24595-y.

  PMID: 41034877 DERIVED

• Hammoudeh AJ, Aldalal'ah M, Smadi EA, Alrishoud D, Alomari A, Alkhawaldeh M, Rizik A, Okour MF, Araydah M. Absence of Standard Modifiable Risk Factors in Middle Eastern Patients with Atherosclerotic Cardiovascular Disease. The Jordan Absence of Standard Modifiable Risk Factors (SMuRF-Less) Study. Vasc Health Risk Manag. 2025 Feb 5;21:39-50. doi: 10.2147/VHRM.S499355. eCollection 2025.

  PMID: 39931041 DERIVED

MeSH Terms

Conditions

Atherosclerosis

Condition Hierarchy (Ancestors)

Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 25, 2023
• First Posted: January 10, 2024
• Study Start: January 22, 2024
• Primary Completion: January 1, 2025
• Study Completion: January 31, 2025
• Last Updated: February 25, 2025

Record last verified: 2025-02

Locations

JO (2)