NCT06197815

Brief Summary

Endoscopic retrograde cholangiopancreatography (ERCP) is a technically challenging procedure. It takes time to learn the basic skill and at least 180 - 200 cases for trainees to achieve competency in ERCP. Hands-on practice in patients remains the gold standard for ERCP training. It required the trainer to stand by the trainee in the procedure room to assist. There were insufficient patients for most trainees to achieve competence until the trainee graduate. Technology-enabled health care at a distance has profound scientific potential and accordingly has been met with growing interest. We hypothesized that the trainee can be safely guided by a senior trainer off-site with the endoscopic view displayed on a screen. Using the teleguidance, the trainer can even continue to provide guidance when the trainees complete their training and return to their hospitals until they achieve the recommended clinical competency. Given the advantages of the off-site teleguidance, it could be an attractive substitute for hands-on assistance to ERCP training. The primary aim of this study was to evaluate whether off-site assistance (OA group) could achieve a comparable success rate to standard hands-on assistance (HA group) with regard to the rates of successful selective biliary cannulation during ERCP training.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
754

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Dec 2020

Longer than P75 for not_applicable

Geographic Reach
1 country

3 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 3, 2020

Completed
3.1 years until next milestone

First Submitted

Initial submission to the registry

December 27, 2023

Completed
13 days until next milestone

First Posted

Study publicly available on registry

January 9, 2024

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2024

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2024

Completed
Last Updated

January 17, 2024

Status Verified

January 1, 2024

Enrollment Period

3.5 years

First QC Date

December 27, 2023

Last Update Submit

January 16, 2024

Conditions

Outcome Measures

Primary Outcomes (1)

  • Rates of successful biliary cannulation

    The percentage of trainee successfully biliary cannulation

    10 minutes

Secondary Outcomes (4)

  • Cannulation time

    1 day

  • Competency score from the trainer and endoscopic video

    1 day

  • Incidences of PEP and other adverse events

    1 month

  • Ionizing radiation time

    1 day

Study Arms (2)

Off-site assistance group

EXPERIMENTAL

The trainer supervised the trainee's cannulation operation outside the procedure room through a high-definition screen displaying the endoscopic view. Trainees wear headphones, and trainers use intercom to provide the unlimited verbal instructions. The trainer was not allowed into the procedure room and touched the endoscope or accessories until the trainee ask for help or failed to achieve deep biliary cannulation. Then the trainer would then take over and continue with the cannulation. The trainer would halt and correct the trainee's inappropriate maneuvers immediately to avoid unnecessary papillary trauma and potential complications.

Behavioral: The assistance type during ERCP

Hands-on assistance group

ACTIVE COMPARATOR

During trainees' attempted cannulation, the trainer gave unlimited verbal instructions with hands-on assistance limited to only adjustment of scope position if necessary. To avoid unintended cannulation, the trainer was not allowed to touch the control section of the scope or the sphincterotome used for cannulation. However, the trainer would correct any inappropriate maneuvers immediately to avoid unnecessary papillary trauma and potential complications. The trainees could ask for help or stop cannulation at any time if they were not comfortable continuing the procedure. The trainer would then take over and continue with the cannulation.

Behavioral: The assistance type during ERCP

Interventions

The senior trainer guides the trainees during ERCP procedure outside the operating room using communication equipment and the screen displaying an endoscopic view.

Hands-on assistance groupOff-site assistance group

Eligibility Criteria

Age18 Years - 90 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients aged 18-90 years who received ERCP
  • Patients with native papilla

You may not qualify if:

  • Patients with altered anatomy (Billroth I/II, Roux-en-Y)
  • Type II duodenal stenosis
  • Previously failed cannulation
  • Chronic pancreatitis with stones in the pancreatic head
  • Hemodynamic instability
  • Lactating or pregnant women
  • Inability to give written informed consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Department of Gastroenterology, The Second Affiliated Hospital Chongqing Medical University

Chongqing, Chongqing Municipality, 400010, China

RECRUITING

Xijing Hospital of Digestive Diseases, Fourth Military Medical University

Xi'an, Shaanxi, 710032, China

RECRUITING

Department of Endoscopy, Eastern Hepatobiliary Hospital, Second Military Medical University

Shanghai, Shanghai Municipality, 201823, China

RECRUITING

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

December 27, 2023

First Posted

January 9, 2024

Study Start

December 3, 2020

Primary Completion

June 1, 2024

Study Completion

August 1, 2024

Last Updated

January 17, 2024

Record last verified: 2024-01

Data Sharing

IPD Sharing
Will not share

Locations