Individual Cerebral Hemodynamic Oxygenation Relationships (ICHOR 1)
ICHOR 1
2 other identifiers
observational
1,000
1 country
1
Brief Summary
This is an observational study in patients who require clinical anesthesia. The main purpose of this study is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by different types of anesthesia. Subjects who require clinical anesthesia for a clinical MRI and for whom the use of anesthetics for the exam are in clinical equipoise are asked to join the study. All eligible subjects will be asked to provide informed consent before participating in the study.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2018
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2018
CompletedFirst Submitted
Initial submission to the registry
December 22, 2023
CompletedFirst Posted
Study publicly available on registry
January 8, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2030
ExpectedStudy Completion
Last participant's last visit for all outcomes
November 1, 2035
April 29, 2026
April 1, 2026
12 years
December 22, 2023
April 24, 2026
Conditions
Outcome Measures
Primary Outcomes (2)
Change in cerebral blood flow (ml blood/100g/min)
Phase contrast (PC) acquisition via MRI will be used to assess any impact of anesthesia on cerebral blood flow.
Time points over which the change is assessed: change from (1) start of MRI, through (2) MRI completion, an average of 60 minutes.
Change in cerebral metabolic rate of oxygen (ml O2/100g/min)
T2 relaxation under spin tagging (TRUST) acquisition via MRI will be used to assess any impact of anesthesia on cerebral metabolic rate of oxygen.
Time points over which the change is assessed: change from (1) start of MRI, through (2) MRI completion, an average of 60 minutes.
Study Arms (1)
Pediatric Patients
Children scheduled for clinical MR imaging.
Interventions
MR imaging pertaining to the patient and project (ICHOR 1)
Eligibility Criteria
Neonates and young children
You may qualify if:
- Individuals who are able to tolerate an MRI.
- Are patients scheduled for a clinically indicated MRI.
- Between birth and up to 18 years.
You may not qualify if:
- Presence of an MRI-incompatible device or implant (e.g. pacemakers, stents)
- Unable to tolerate the enclosed spaces and loud noises for the duration of time in scanner required to obtain an MRI.
- Preterm infants less than 25 weeks
- Any patient who is clinically too unstable to extend their MRI by up-to 7.5 minutes.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Matthew Borzage, PhD
Children's Hospital Los Angeles
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
December 22, 2023
First Posted
January 8, 2024
Study Start
November 1, 2018
Primary Completion (Estimated)
November 1, 2030
Study Completion (Estimated)
November 1, 2035
Last Updated
April 29, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will share