Feasibility of Using Real-time Cine-MRI for Treating Moving & Deforming Tumors

NCT01071434 | Terminated

• 2 other identifiers: VAR0042SU-06112009-2702
• Study Type: observational
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate and optimize imaging sequences and parameters of rapid real-time MRI in order to obtain adequate guidance for accurately and precisely delivering radiation to moving abdominal and thoracic tumors.

Conditions

Pancreatic Cancer; Liver Cancer; Lung Cancer; Lung Cancer Non-Small Cell Cancer (NSCLC); Lung Cancer Small Cell Lung Cancer (SCLC); Hepatobiliary Cancers; Hepatobiliary Cancers Liver; Hepatobiliary Cancers Hepatocellular Carcinoma (Hepatoma); Hepatobiliary Cancers Gallbladder; Hepatobiliary Cancers Bile Duct

Outcome Measures

Primary Outcomes (1)

• investigate and optimize imaging sequences and parameters of rapid real-time MRI in order to obtain adequate guidance for accurately and precisely delivering radiation to moving abdominal and thoracic tumors.

  two hours

Interventions

MR Imaging PROCEDURE

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Eligible disease(s)/stage(s) \\AJCC Stage I, II, III or IV lung, liver or pancreatic cancer of any histology to be treated using radiotherapy will be eligible for this study.

You may qualify if:

• Allowable type and amount of prior therapy \ Any types and amounts of prior therapy will be allowed for this study.
• Age restriction and/or gender/ethnic restrictions \\Patients must be greater than or equal to 18 years of age. There are no gender or ethnic restrictions.
• Life expectancy restrictions \ None.
• ECOG or Karnofsky Performance Status \ Karnofsky performance status of 50 or greater
• Requirements for organ and marrow function \ None.
• Ability to understand and the willingness to sign a written informed consent document.

You may not qualify if:

• Metallic implants, embedded metallic objects, implanted biomedical devices e.g., cardiac pacemakers
• Women who are pregnant or trying to get pregnant
• Pain in supine position
• Karnofsky performance status \< 50

Sponsors & Collaborators

• Stanford University: lead
• The American Association of Physicists in Medicine: collaborator

Study Sites (1)

Stanford University School of Medicine

Stanford, California, 94305, United States

Location

MeSH Terms

Conditions

Pancreatic Neoplasms; Liver Neoplasms; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Small Cell Lung Carcinoma; Carcinoma, Hepatocellular

Interventions

Magnetic Resonance Spectroscopy

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Endocrine Gland Neoplasms; Digestive System Diseases; Pancreatic Diseases; Endocrine System Diseases; Liver Diseases; Respiratory Tract Neoplasms; Thoracic Neoplasms; Lung Diseases; Respiratory Tract Diseases; Carcinoma, Bronchogenic; Bronchial Neoplasms; Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type

Intervention Hierarchy (Ancestors)

Spectrum Analysis; Chemistry Techniques, Analytical; Investigative Techniques

Study Officials

• Amit Sawant

  Stanford University

  PRINCIPAL INVESTIGATOR

• Paul J Keall

  Stanford University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 16, 2009
• First Posted: February 19, 2010
• Study Start: February 1, 2009
• Primary Completion: September 1, 2010
• Study Completion: September 1, 2010
• Last Updated: December 7, 2012

Record last verified: 2012-12

Locations

US (1)